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Protein

Major outer membrane protein P.IA

Gene

porA

Organism
Neisseria meningitidis serogroup B (strain MC58)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Serves as a slightly cation selective porin. Major antigen on the gonococcal cell surface and it may have pathogenic properties in addition to its porin activity.

Miscellaneous

Present in outer membrane vesicle formulations which are used as vaccines in human.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPorin
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Major outer membrane protein P.IA
Short name:
PIA
Short name:
Protein IA
Alternative name(s):
Class 1 protein
Gene namesi
Name:porA
Ordered Locus Names:NMB1429
OrganismiNeisseria meningitidis serogroup B (strain MC58)
Taxonomic identifieri122586 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000002527420 – 392Major outer membrane protein P.IAAdd BLAST373

Proteomic databases

PaxDbiP0DH58.

Interactioni

Subunit structurei

Homotrimer.

Protein-protein interaction databases

STRINGi122586.NMB1429.

Structurei

3D structure databases

ProteinModelPortaliP0DH58.
SMRiP0DH58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gram-negative porin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiCOG3203. LUCA.
HOGENOMiHOG000114654.
KOiK18132.
OMAiAHGFDFI.
OrthoDBiPOG091H0GKV.

Family and domain databases

CDDicd00342. gram_neg_porins. 1 hit.
InterProiView protein in InterPro
IPR033900. Gram_neg_porin_domain.
IPR001702. Porin_Gram-ve.
IPR013793. Porin_Gram-ve_CS.
IPR002299. Porin_Neis.
PfamiView protein in Pfam
PF00267. Porin_1. 1 hit.
PRINTSiPR00182. ECOLNEIPORIN.
PR00184. NEISSPPORIN.
PROSITEiView protein in PROSITE
PS00576. GRAM_NEG_PORIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DH58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKKLTALVL SALPLAAVAD VSLYGEIKAG VEGRNYQLQL TEAQAANGGA
60 70 80 90 100
SGQVKVTKVT KAKSRIRTKI SDFGSFIGFK GSEDLGDGLK AVWQLEQDVS
110 120 130 140 150
VAGGGATQWG NRESFIGLAG EFGTLRAGRV ANQFDDASQA IDPWDSNNDV
160 170 180 190 200
ASQLGIFKRH DDMPVSVRYD SPEFSGFSGS VQFVPIQNSK SAYTPAYYTK
210 220 230 240 250
NTNNNLTLVP AVVGKPGSDV YYAGLNYKNG GFAGNYAFKY ARHANVGRNA
260 270 280 290 300
FELFLIGSGS DQAKGTDPLK NHQVHRLTGG YEEGGLNLAL AAQLDLSENG
310 320 330 340 350
DKTKNSTTEI AATASYRFGN AVPRISYAHG FDFIERGKKG ENTSYDQIIA
360 370 380 390
GVDYDFSKRT SAIVSGAWLK RNTGIGNYTQ INAASVGLRH KF
Length:392
Mass (Da):42,078
Last modified:July 27, 2011 - v1
Checksum:i1D78EA55BF76E940
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002098 Genomic DNA. Translation: AAF41790.1.
AF226344 Genomic DNA. Translation: AAF42493.1.
PIRiF81084.
RefSeqiNP_274441.1. NC_003112.2.
WP_010980936.1. NC_003112.2.

Genome annotation databases

EnsemblBacteriaiAAF41790; AAF41790; NMB1429.
GeneIDi903851.
KEGGinme:NMB1429.
PATRICifig|122586.8.peg.1791.

Similar proteinsi

Entry informationi

Entry nameiOMPA_NEIMB
AccessioniPrimary (citable) accession number: P0DH58
Secondary accession number(s): Q51240
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: June 7, 2017
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families