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P0DH30

- UPPP_STRP3

UniProt

P0DH30 - UPPP_STRP3

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, bacA, upk, SpyM3_0205
Organism
Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSPYO198466:GJDL-255-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:SpyM3_0205
OrganismiStreptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Taxonomic identifieri198466 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000564: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Reviewed prediction
Add
BLAST
Transmembranei44 – 6421Helical; Reviewed prediction
Add
BLAST
Transmembranei85 – 10521Helical; Reviewed prediction
Add
BLAST
Transmembranei113 – 13321Helical; Reviewed prediction
Add
BLAST
Transmembranei163 – 18321Helical; Reviewed prediction
Add
BLAST
Transmembranei188 – 20821Helical; Reviewed prediction
Add
BLAST
Transmembranei223 – 24321Helical; Reviewed prediction
Add
BLAST
Transmembranei255 – 27521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Undecaprenyl-diphosphataseUniRule annotation
PRO_0000151217Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0DH30.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000218356.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0DH30-1 [UniParc]FASTAAdd to Basket

« Hide

MLIIELLKAI FFGIIEGITE WLPVSSTGHL ILVQEFIRLN QDKAFIEMFN    50
IVIQLGAIIA VMLIYFERLN PFQPGKTARE VQLTWQLWLK VVIACIPSIL 100
IAVPLDNWFE AHFYFMVPIA IALIVYGIAF IWIEKRNAQQ EPAVTELARM 150
SYKTAFFIGC FQVLSIVPGT SRSGATILGA IILGTSRTVA ADFTFFLAIP 200
TMFGYSGLKA VKFFLDGHHL DFAQVLILLV ASLTAFVVSL LAIRFLTDYV 250
KKHDFTIFGK YRIVLGSLLL IYSFFKFVF 279
Length:279
Mass (Da):31,538
Last modified:July 27, 2011 - v1
Checksum:iAB0EC20DBD1B8A30
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014074 Genomic DNA. Translation: AAM78812.1.
RefSeqiNP_664009.1. NC_004070.1.

Genome annotation databases

EnsemblBacteriaiAAM78812; AAM78812; SpyM3_0205.
GeneIDi1008519.
KEGGispg:SpyM3_0205.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014074 Genomic DNA. Translation: AAM78812.1 .
RefSeqi NP_664009.1. NC_004070.1.

3D structure databases

ProteinModelPortali P0DH30.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM78812 ; AAM78812 ; SpyM3_0205 .
GeneIDi 1008519.
KEGGi spg:SpyM3_0205.

Phylogenomic databases

HOGENOMi HOG000218356.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci SPYO198466:GJDL-255-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence."
    Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D., Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S., Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-595 / MGAS315.

Entry informationi

Entry nameiUPPP_STRP3
AccessioniPrimary (citable) accession number: P0DH30
Secondary accession number(s): P67393, Q9A1G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: May 14, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi