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P0DG73

- HASC2_STRPQ

UniProt

P0DG73 - HASC2_STRPQ

Protein

UTP--glucose-1-phosphate uridylyltransferase 2

Gene

hasC2

Organism
Streptococcus pyogenes serotype M3 (strain SSI-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

    Pathwayi

    GO - Molecular functioni

    1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. biosynthetic process Source: InterPro
    2. UDP-glucose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciSPYO193567:GHDO-203-MONOMER.
    UniPathwayiUPA00215.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase 2 (EC:2.7.7.9)
    Alternative name(s):
    Alpha-D-glucosyl-1-phosphate uridylyltransferase 2
    UDP-glucose pyrophosphorylase 2
    Short name:
    UDPGP 2
    Uridine diphosphoglucose pyrophosphorylase 2
    Gene namesi
    Name:hasC2
    Synonyms:hasC.2
    Ordered Locus Names:SPs0166
    OrganismiStreptococcus pyogenes serotype M3 (strain SSI-1)
    Taxonomic identifieri193567 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002699: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299UTP--glucose-1-phosphate uridylyltransferase 2PRO_0000411626Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0DG73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDPGP type 2 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000283477.
    KOiK00963.
    OMAiYESTHAS.
    OrthoDBiEOG6Z9B3V.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF00483. NTP_transferase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR01099. galU. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0DG73-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI    50
    EEILIVTGKS KRSIEDHFDS NFELEYNLQA KGKIELLKLV DETTSINLHF 100
    IRQSHPRGLG DAVLQAKTFV GNEPFVVMLG DDLMDITNPN VKPLTKQLID 150
    DYEETHAATI AVMRVPHEDV SNYGIIAPQA KAVKGLYSVD TFVEKPQPQD 200
    APSDLAIIGR YLLTPEIFSI LEKQEPGAGN EVQLTDAIDT LNKTQRVFAR 250
    EFKGKRYDVG DKFGFMKTSL DYALKHPQVK DDLKAYIIQL GKALEKTKP 299
    Length:299
    Mass (Da):33,302
    Last modified:July 27, 2011 - v1
    Checksum:iD927314E58F6091B
    GO

    Sequence cautioni

    The sequence BAC63261.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000034 Genomic DNA. Translation: BAC63261.1. Different initiation.
    RefSeqiNP_801428.1. NC_004606.1.
    WP_011106591.1. NC_004606.1.

    Genome annotation databases

    EnsemblBacteriaiBAC63261; BAC63261; BAC63261.
    GeneIDi1065625.
    KEGGisps:SPs0166.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000034 Genomic DNA. Translation: BAC63261.1 . Different initiation.
    RefSeqi NP_801428.1. NC_004606.1.
    WP_011106591.1. NC_004606.1.

    3D structure databases

    ProteinModelPortali P0DG73.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC63261 ; BAC63261 ; BAC63261 .
    GeneIDi 1065625.
    KEGGi sps:SPs0166.

    Phylogenomic databases

    HOGENOMi HOG000283477.
    KOi K00963.
    OMAi YESTHAS.
    OrthoDBi EOG6Z9B3V.

    Enzyme and pathway databases

    UniPathwayi UPA00215 .
    BioCyci SPYO193567:GHDO-203-MONOMER.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR005771. GalU_uridylyltTrfase_bac/arc.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF00483. NTP_transferase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR01099. galU. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution."
      Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y., Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T., Hayashi H., Hattori M., Hamada S.
      Genome Res. 13:1042-1055(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SSI-1.

    Entry informationi

    Entry nameiHASC2_STRPQ
    AccessioniPrimary (citable) accession number: P0DG73
    Secondary accession number(s): P58098, P67069
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3