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P0DG73

- HASC2_STRPQ

UniProt

P0DG73 - HASC2_STRPQ

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Protein

UTP--glucose-1-phosphate uridylyltransferase 2

Gene
hasC2, hasC.2, SPs0166
Organism
Streptococcus pyogenes serotype M3 (strain SSI-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathwayi

GO - Molecular functioni

  1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. biosynthetic process Source: InterPro
  2. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Enzyme and pathway databases

BioCyciSPYO193567:GHDO-203-MONOMER.
UniPathwayiUPA00215.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase 2 (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase 2
UDP-glucose pyrophosphorylase 2
Short name:
UDPGP 2
Uridine diphosphoglucose pyrophosphorylase 2
Gene namesi
Name:hasC2
Synonyms:hasC.2
Ordered Locus Names:SPs0166
OrganismiStreptococcus pyogenes serotype M3 (strain SSI-1)
Taxonomic identifieri193567 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002699: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299UTP--glucose-1-phosphate uridylyltransferase 2PRO_0000411626Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0DG73.

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.

Phylogenomic databases

HOGENOMiHOG000283477.
KOiK00963.
OMAiYESTHAS.
OrthoDBiEOG6Z9B3V.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01099. galU. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DG73-1 [UniParc]FASTAAdd to Basket

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MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI    50
EEILIVTGKS KRSIEDHFDS NFELEYNLQA KGKIELLKLV DETTSINLHF 100
IRQSHPRGLG DAVLQAKTFV GNEPFVVMLG DDLMDITNPN VKPLTKQLID 150
DYEETHAATI AVMRVPHEDV SNYGIIAPQA KAVKGLYSVD TFVEKPQPQD 200
APSDLAIIGR YLLTPEIFSI LEKQEPGAGN EVQLTDAIDT LNKTQRVFAR 250
EFKGKRYDVG DKFGFMKTSL DYALKHPQVK DDLKAYIIQL GKALEKTKP 299
Length:299
Mass (Da):33,302
Last modified:July 27, 2011 - v1
Checksum:iD927314E58F6091B
GO

Sequence cautioni

The sequence BAC63261.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000034 Genomic DNA. Translation: BAC63261.1. Different initiation.
RefSeqiNP_801428.1. NC_004606.1.
WP_011106591.1. NC_004606.1.

Genome annotation databases

EnsemblBacteriaiBAC63261; BAC63261; BAC63261.
GeneIDi1065625.
KEGGisps:SPs0166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000034 Genomic DNA. Translation: BAC63261.1 . Different initiation.
RefSeqi NP_801428.1. NC_004606.1.
WP_011106591.1. NC_004606.1.

3D structure databases

ProteinModelPortali P0DG73.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC63261 ; BAC63261 ; BAC63261 .
GeneIDi 1065625.
KEGGi sps:SPs0166.

Phylogenomic databases

HOGENOMi HOG000283477.
KOi K00963.
OMAi YESTHAS.
OrthoDBi EOG6Z9B3V.

Enzyme and pathway databases

UniPathwayi UPA00215 .
BioCyci SPYO193567:GHDO-203-MONOMER.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF00483. NTP_transferase. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR01099. galU. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution."
    Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y., Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T., Hayashi H., Hattori M., Hamada S.
    Genome Res. 13:1042-1055(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SSI-1.

Entry informationi

Entry nameiHASC2_STRPQ
AccessioniPrimary (citable) accession number: P0DG73
Secondary accession number(s): P58098, P67069
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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