ID   HASC1_STRP3             Reviewed;         304 AA.
AC   P0DG70; Q79VY2; Q8K5G4;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase 1;
DE            EC=2.7.7.9;
DE   AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase 1;
DE   AltName: Full=UDP-glucose pyrophosphorylase 1;
DE            Short=UDPGP 1;
DE   AltName: Full=Uridine diphosphoglucose pyrophosphorylase 1;
GN   Name=hasC1; Synonyms=hasC; OrderedLocusNames=SpyM3_1853;
OS   Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=198466;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-595 / MGAS315;
RX   PubMed=12122206; DOI=10.1073/pnas.152298499;
RA   Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D.,
RA   Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S.,
RA   Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.;
RT   "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-
RT   encoded toxins, the high-virulence phenotype, and clone emergence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC         alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC         ChEBI:CHEBI:58885; EC=2.7.7.9;
CC   -!- PATHWAY: Carbohydrate metabolism; nucleotide-sugar metabolism.
CC   -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}.
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DR   EMBL; AE014074; AAM80460.1; -; Genomic_DNA.
DR   RefSeq; WP_002982024.1; NC_004070.1.
DR   AlphaFoldDB; P0DG70; -.
DR   SMR; P0DG70; -.
DR   GeneID; 69901620; -.
DR   KEGG; spg:SpyM3_1853; -.
DR   HOGENOM; CLU_029499_1_2_9; -.
DR   UniPathway; UPA00215; -.
DR   Proteomes; UP000000564; Chromosome.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   CDD; cd02541; UGPase_prokaryotic; 1.
DR   InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   NCBIfam; TIGR01099; galU; 1.
DR   PANTHER; PTHR43197; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR   PANTHER; PTHR43197:SF1; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..304
FT                   /note="UTP--glucose-1-phosphate uridylyltransferase 1"
FT                   /id="PRO_0000201369"
SQ   SEQUENCE   304 AA;  33706 MW;  5D717DF01DBC4411 CRC64;
     MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI EEILVVTGKA
     KRSIEDHFDS NFELEYNLQA KGKNELLKLV DETTAINLHF IRQSHPRGLG DAVLQAKAFV
     GNEPFVVMLG DDLMDITNAS AKPLTKQLME DYDKTHASTI AVMKVPHEDV SSYGVIAPQG
     KAVKGLYSVD TFVEKPQPED APSDLAIIGR YLLTPEIFDI LERQVPGAGN EVQLTDAIDT
     LNKTQRVFAR EFKGNRYDVG DKFGFMKTSI DYALEHPQVK EDLKNYIIKL GKALEKSKVP
     THSK
//