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P0DG70

- HASC1_STRP3

UniProt

P0DG70 - HASC1_STRP3

Protein

UTP--glucose-1-phosphate uridylyltransferase 1

Gene

hasC1

Organism
Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

    Pathwayi

    GO - Molecular functioni

    1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. biosynthetic process Source: InterPro
    2. UDP-glucose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciSPYO198466:GJDL-1937-MONOMER.
    UniPathwayiUPA00215.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase 1 (EC:2.7.7.9)
    Alternative name(s):
    Alpha-D-glucosyl-1-phosphate uridylyltransferase 1
    UDP-glucose pyrophosphorylase 1
    Short name:
    UDPGP 1
    Uridine diphosphoglucose pyrophosphorylase 1
    Gene namesi
    Name:hasC1
    Synonyms:hasC
    Ordered Locus Names:SpyM3_1853
    OrganismiStreptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
    Taxonomic identifieri198466 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000564: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 304304UTP--glucose-1-phosphate uridylyltransferase 1PRO_0000201369Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0DG70.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDPGP type 2 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000283477.
    KOiK00963.
    OMAiMDEIMTN.
    OrthoDBiEOG6Z9B3V.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF00483. NTP_transferase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR01099. galU. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0DG70-1 [UniParc]FASTAAdd to Basket

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    MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI    50
    EEILVVTGKA KRSIEDHFDS NFELEYNLQA KGKNELLKLV DETTAINLHF 100
    IRQSHPRGLG DAVLQAKAFV GNEPFVVMLG DDLMDITNAS AKPLTKQLME 150
    DYDKTHASTI AVMKVPHEDV SSYGVIAPQG KAVKGLYSVD TFVEKPQPED 200
    APSDLAIIGR YLLTPEIFDI LERQVPGAGN EVQLTDAIDT LNKTQRVFAR 250
    EFKGNRYDVG DKFGFMKTSI DYALEHPQVK EDLKNYIIKL GKALEKSKVP 300
    THSK 304
    Length:304
    Mass (Da):33,706
    Last modified:July 27, 2011 - v1
    Checksum:i5D717DF01DBC4411
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014074 Genomic DNA. Translation: AAM80460.1.
    RefSeqiNP_665657.1. NC_004070.1.

    Genome annotation databases

    EnsemblBacteriaiAAM80460; AAM80460; SpyM3_1853.
    GeneIDi1010168.
    KEGGispg:SpyM3_1853.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014074 Genomic DNA. Translation: AAM80460.1 .
    RefSeqi NP_665657.1. NC_004070.1.

    3D structure databases

    ProteinModelPortali P0DG70.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM80460 ; AAM80460 ; SpyM3_1853 .
    GeneIDi 1010168.
    KEGGi spg:SpyM3_1853.

    Phylogenomic databases

    HOGENOMi HOG000283477.
    KOi K00963.
    OMAi MDEIMTN.
    OrthoDBi EOG6Z9B3V.

    Enzyme and pathway databases

    UniPathwayi UPA00215 .
    BioCyci SPYO198466:GJDL-1937-MONOMER.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR005771. GalU_uridylyltTrfase_bac/arc.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF00483. NTP_transferase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR01099. galU. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence."
      Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D., Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S., Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.
      Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-595 / MGAS315.

    Entry informationi

    Entry nameiHASC1_STRP3
    AccessioniPrimary (citable) accession number: P0DG70
    Secondary accession number(s): Q79VY2, Q8K5G4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3