P0DG70 (HASC1_STRP3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UTP--glucose-1-phosphate uridylyltransferase 1
EC=2.7.7.9

Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase 1
UDP-glucose pyrophosphorylase 1
Short name=UDPGP 1
Uridine diphosphoglucose pyrophosphorylase 1

Gene names

Name:	hasC1
Synonyms:	hasC
Ordered Locus Names:	SpyM3_1853

Organism

Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) [Complete proteome] [HAMAP]

Taxonomic identifier

198466 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pyogenes › Streptococcus pyogenes serotype M3

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Carbohydrate metabolism; nucleotide-sugar metabolism.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	UTP--glucose-1-phosphate uridylyltransferase 1		PRO_0000201369

Sequences

	Sequence		Length	Mass (Da)
	P0DG70 [UniParc]. Last modified July 27, 2011. Version 1. Checksum: 5D717DF01DBC4411	FASTA	304	33,706
	10 20 30 40 50 60 MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI EEILVVTGKA 70 80 90 100 110 120 KRSIEDHFDS NFELEYNLQA KGKNELLKLV DETTAINLHF IRQSHPRGLG DAVLQAKAFV 130 140 150 160 170 180 GNEPFVVMLG DDLMDITNAS AKPLTKQLME DYDKTHASTI AVMKVPHEDV SSYGVIAPQG 190 200 210 220 230 240 KAVKGLYSVD TFVEKPQPED APSDLAIIGR YLLTPEIFDI LERQVPGAGN EVQLTDAIDT 250 260 270 280 290 300 LNKTQRVFAR EFKGNRYDVG DKFGFMKTSI DYALEHPQVK EDLKNYIIKL GKALEKSKVP THSK

References

[1]

"Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence." Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D., Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S., Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-595 / MGAS315.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014074 Genomic DNA. Translation: AAM80460.1.
RefSeq	NP_665657.1. NC_004070.1.
3D structure databases
ProteinModelPortal	P0DG70.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM80460; AAM80460; SpyM3_1853.
GeneID	1010168.
KEGG	spg:SpyM3_1853.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000283477.
KO	K00963.
OMA	YIVREAI.
Enzyme and pathway databases
BioCyc	SPYO198466:GJDL-1937-MONOMER.
UniPathway	UPA00215.
Family and domain databases
InterPro	IPR005771. GalU_uridylyltTrfase_bac/arc. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01099. galU. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HASC1_STRP3

Accession

Primary (citable) accession number: P0DG70
Secondary accession number(s): Q79VY2, Q8K5G4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	July 27, 2011
Last modified:	May 29, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program