SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0DG33

- SYC_STRPQ

UniProt

P0DG33 - SYC_STRPQ

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cysteine--tRNA ligase

Gene
cysS, SPs1673
Organism
Streptococcus pyogenes serotype M3 (strain SSI-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi28 – 281Zinc By similarity
Metal bindingi211 – 2111Zinc By similarity
Metal bindingi236 – 2361Zinc By similarity
Metal bindingi240 – 2401Zinc By similarity
Binding sitei271 – 2711ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. cysteine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cysteinyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciSPYO193567:GHDO-1738-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine--tRNA ligase (EC:6.1.1.16)
Alternative name(s):
Cysteinyl-tRNA synthetase
Short name:
CysRS
Gene namesi
Name:cysS
Ordered Locus Names:SPs1673
OrganismiStreptococcus pyogenes serotype M3 (strain SSI-1)
Taxonomic identifieri193567 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002699: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Cysteine--tRNA ligaseUniRule annotationPRO_0000411606Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP0DG33.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi30 – 4011"HIGH" regionUniRule annotationAdd
BLAST
Motifi268 – 2725"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000245250.
KOiK01883.
OMAiEPDEIAW.
OrthoDBiEOG6RVFXC.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00041. Cys_tRNA_synth.
InterProiIPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR10890. PTHR10890. 1 hit.
PfamiPF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSiPR00983. TRNASYNTHCYS.
SMARTiSM00840. DALR_2. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00435. cysS. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DG33-1 [UniParc]FASTAAdd to Basket

« Hide

MIKIYDTMTR SLRKFVPLTE NTVNMYVCGP TVYNYIHIGN ARSAVAFDTI    50
RRYFEYTGYQ VNYISNFTDI DDKIIKAATQ AGVSPKELSD RFIAAFIEDT 100
KALGVKPATQ NPRVMDYIAE IISFVESLIE KDFAYEADGD VYFRVEKSEH 150
YAKLANKTLS ELEVGASGRT DAETALKENP LDFALWKSAK AGEVSWDSPW 200
GFGRPGWHIE CSVMATEILG DTIDIHGGGA DLEFPHHTNE IAQSEAKTGK 250
TFANYWMHNG FVTVDNEKMS KSLGNFVTVH DMLQTVDGQV LRFFLATQQY 300
RKPINFTEKA IHDAEINLKY LKNTLQQPLT ETADEQELKQ FVIAFQDAMD 350
DDFNTANGIT VVFDMAKWIN SGSYTEPVKS AFEKMLAVFG IIFEEEVLEV 400
DIEALIAKRQ EARANRDFAT ADAIRDQLAA QGIKLLDTKD GVRWLRD 447
Length:447
Mass (Da):50,465
Last modified:July 27, 2011 - v1
Checksum:i5C892A47E3C5C297
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000034 Genomic DNA. Translation: BAC64768.1.
RefSeqiNP_802935.1. NC_004606.1.

Genome annotation databases

EnsemblBacteriaiBAC64768; BAC64768; BAC64768.
GeneIDi1066349.
KEGGisps:SPs1673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000034 Genomic DNA. Translation: BAC64768.1 .
RefSeqi NP_802935.1. NC_004606.1.

3D structure databases

ProteinModelPortali P0DG33.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC64768 ; BAC64768 ; BAC64768 .
GeneIDi 1066349.
KEGGi sps:SPs1673.

Phylogenomic databases

HOGENOMi HOG000245250.
KOi K01883.
OMAi EPDEIAW.
OrthoDBi EOG6RVFXC.

Enzyme and pathway databases

BioCyci SPYO193567:GHDO-1738-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00041. Cys_tRNA_synth.
InterProi IPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR10890. PTHR10890. 1 hit.
Pfami PF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view ]
PRINTSi PR00983. TRNASYNTHCYS.
SMARTi SM00840. DALR_2. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
TIGRFAMsi TIGR00435. cysS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution."
    Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y., Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T., Hayashi H., Hattori M., Hamada S.
    Genome Res. 13:1042-1055(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SSI-1.

Entry informationi

Entry nameiSYC_STRPQ
AccessioniPrimary (citable) accession number: P0DG33
Secondary accession number(s): Q8K5T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: May 14, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi