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Protein

tRNA (guanine-N(1)-)-methyltransferase

Gene

trmD

Organism
Streptococcus pyogenes serotype M3 (strain SSI-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically methylates guanosine-37 in various tRNAs.By similarity

Catalytic activityi

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N1-methylguanine(37) in tRNA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei108S-adenosyl-L-methionine; via amide nitrogenBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(1)-)-methyltransferase (EC:2.1.1.228)
Alternative name(s):
M1G-methyltransferase
tRNA [GM37] methyltransferase
Gene namesi
Name:trmD
Ordered Locus Names:SPs1280
OrganismiStreptococcus pyogenes serotype M3 (strain SSI-1)
Taxonomic identifieri193567 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004116001 – 243tRNA (guanine-N(1)-)-methyltransferaseAdd BLAST243

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0DG21.
SMRiP0DG21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 132S-adenosyl-L-methionine bindingBy similarity6

Sequence similaritiesi

Belongs to the RNA methyltransferase TrmD family.Curated

Phylogenomic databases

HOGENOMiHOG000016242.
KOiK00554.
OMAiILCGHYK.

Family and domain databases

Gene3Di1.10.1270.20. 1 hit.
3.40.1280.10. 1 hit.
HAMAPiMF_00605. TrmD. 1 hit.
InterProiView protein in InterPro
IPR029028. Alpha/beta_knot_MTases.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
IPR029026. tRNA_m1G_MTases_N.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
PANTHERiPTHR32125:SF1. PTHR32125:SF1. 1 hit.
PfamiView protein in Pfam
PF01746. tRNA_m1G_MT. 1 hit.
PIRSFiPIRSF000386. tRNA_mtase. 1 hit.
SUPFAMiSSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00088. trmD. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DG21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIDILTLFP EMFAPLEHSI VGKAKEKGLL DIHYHNFRDY AEKARHVDDE
60 70 80 90 100
PYGGGQGMLL RAQPIFDTIE QIEAKKPRII LLDPAGKPFT QAYAEELALE
110 120 130 140 150
EELIFICGHY EGYDERIKTL VTDEISLGDF VLTGGELAAM TMVDATVRLI
160 170 180 190 200
PQVLGKESSH QDDSFSSGLL EYPQYTRPYD YRGMTVPDVL MSGHHERIRL
210 220 230 240
WRLEESLRKT YLRRPDLLER YDFSEEERKL LDKIKEALGQ GED
Length:243
Mass (Da):27,979
Last modified:July 27, 2011 - v1
Checksum:i25D0A4B59777CFA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000034 Genomic DNA. Translation: BAC64375.1.
RefSeqiWP_002985053.1. NC_004606.1.

Genome annotation databases

EnsemblBacteriaiBAC64375; BAC64375; BAC64375.
KEGGisps:SPs1280.

Similar proteinsi

Entry informationi

Entry nameiTRMD_STRPQ
AccessioniPrimary (citable) accession number: P0DG21
Secondary accession number(s): Q8K7X3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: February 28, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program