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Protein

Superoxide dismutase [Mn]

Gene

sodA

Organism
Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Caution

Although found extracellularly, no signal sequence is present. An alternative secretory pathway may be used.Curated

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27ManganeseBy similarity1
Metal bindingi81ManganeseBy similarity1
Metal bindingi163ManganeseBy similarity1
Metal bindingi167ManganeseBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] (EC:1.15.1.1)
Gene namesi
Name:sodA
Synonyms:sodM
Ordered Locus Names:SpyM3_1071
OrganismiStreptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Taxonomic identifieri198466 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000564 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001601022 – 201Superoxide dismutase [Mn]Add BLAST200

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0DF72
SMRiP0DF72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000013583
KOiK04564
OMAiYEGWKGE

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DF72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIILPELPY AYDALEPQFD AETMTLHHDK HHATYVANTN AALEKHPEIG
60 70 80 90 100
ENLEELLADV TKIPEDIRQA LINNGGGHLN HALFWELLSP EKQDVTSDVA
110 120 130 140 150
QAIDDAFGSF DAFKEQFTAA ATGRFGSGWA WLVVNKEGQL EITSTANQDT
160 170 180 190 200
PISEGKKPIL ALDVWEHAYY LNYRNVRPNY IKAFFEIINW KKVSELYQAA

K
Length:201
Mass (Da):22,657
Last modified:July 27, 2011 - v1
Checksum:i74F066CA96477050
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014074 Genomic DNA Translation: AAM79678.1
RefSeqiWP_011054658.1, NC_004070.1

Genome annotation databases

EnsemblBacteriaiAAM79678; AAM79678; SpyM3_1071
KEGGispg:SpyM3_1071

Similar proteinsi

Entry informationi

Entry nameiSODM_STRP3
AccessioniPrimary (citable) accession number: P0DF72
Secondary accession number(s): Q8K6Y8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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