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P0DF72

- SODM_STRP3

UniProt

P0DF72 - SODM_STRP3

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Protein

Superoxide dismutase [Mn]

Gene

sodA

Organism
Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarityNote: Binds 1 Mn(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271ManganeseBy similarity
Metal bindingi81 – 811ManganeseBy similarity
Metal bindingi163 – 1631ManganeseBy similarity
Metal bindingi167 – 1671ManganeseBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSPYO198466:GJDL-1133-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] (EC:1.15.1.1)
Gene namesi
Name:sodA
Synonyms:sodM
Ordered Locus Names:SpyM3_1071
OrganismiStreptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Taxonomic identifieri198466 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000564: Chromosome

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 201200Superoxide dismutase [Mn]PRO_0000160102Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0DF72.
SMRiP0DF72. Positions 5-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000013583.
KOiK04564.
OMAiPLPYDYN.
OrthoDBiEOG63NMNT.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DF72-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIILPELPY AYDALEPQFD AETMTLHHDK HHATYVANTN AALEKHPEIG
60 70 80 90 100
ENLEELLADV TKIPEDIRQA LINNGGGHLN HALFWELLSP EKQDVTSDVA
110 120 130 140 150
QAIDDAFGSF DAFKEQFTAA ATGRFGSGWA WLVVNKEGQL EITSTANQDT
160 170 180 190 200
PISEGKKPIL ALDVWEHAYY LNYRNVRPNY IKAFFEIINW KKVSELYQAA

K
Length:201
Mass (Da):22,657
Last modified:July 27, 2011 - v1
Checksum:i74F066CA96477050
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014074 Genomic DNA. Translation: AAM79678.1.
RefSeqiNP_664875.1. NC_004070.1.

Genome annotation databases

EnsemblBacteriaiAAM79678; AAM79678; SpyM3_1071.
GeneIDi1009386.
KEGGispg:SpyM3_1071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014074 Genomic DNA. Translation: AAM79678.1 .
RefSeqi NP_664875.1. NC_004070.1.

3D structure databases

ProteinModelPortali P0DF72.
SMRi P0DF72. Positions 5-197.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM79678 ; AAM79678 ; SpyM3_1071 .
GeneIDi 1009386.
KEGGi spg:SpyM3_1071.

Phylogenomic databases

HOGENOMi HOG000013583.
KOi K04564.
OMAi PLPYDYN.
OrthoDBi EOG63NMNT.

Enzyme and pathway databases

BioCyci SPYO198466:GJDL-1133-MONOMER.

Family and domain databases

InterProi IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view ]
PANTHERi PTHR11404. PTHR11404. 1 hit.
Pfami PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000349. SODismutase. 1 hit.
PRINTSi PR01703. MNSODISMTASE.
SUPFAMi SSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEi PS00088. SOD_MN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence."
    Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D., Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S., Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-595 / MGAS315.

Entry informationi

Entry nameiSODM_STRP3
AccessioniPrimary (citable) accession number: P0DF72
Secondary accession number(s): Q8K6Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Although found extracellularly, no signal sequence is present. An alternative secretory pathway may be used.Curated

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3