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P0DF72 (SODM_STRP3) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Superoxide dismutase [Mn]

EC=1.15.1.1
Gene names
Name:sodA
Synonyms:sodM
Ordered Locus Names:SpyM3_1071
OrganismStreptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) [Complete proteome] [HAMAP]
Taxonomic identifier198466 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activity

2 superoxide + 2 H+ = O2 + H2O2.

Cofactor

Binds 1 manganese ion per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the iron/manganese superoxide dismutase family.

Caution

Although found extracellularly, no signal sequence is present. An alternative secretory pathway may be used.

Ontologies

Keywords
   Cellular componentSecreted
   LigandManganese
Metal-binding
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processsuperoxide metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

superoxide dismutase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 201200Superoxide dismutase [Mn]
PRO_0000160102

Sites

Metal binding271Manganese By similarity
Metal binding811Manganese By similarity
Metal binding1631Manganese By similarity
Metal binding1671Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
P0DF72 [UniParc].

Last modified July 27, 2011. Version 1.
Checksum: 74F066CA96477050

FASTA20122,657
        10         20         30         40         50         60 
MAIILPELPY AYDALEPQFD AETMTLHHDK HHATYVANTN AALEKHPEIG ENLEELLADV 

        70         80         90        100        110        120 
TKIPEDIRQA LINNGGGHLN HALFWELLSP EKQDVTSDVA QAIDDAFGSF DAFKEQFTAA 

       130        140        150        160        170        180 
ATGRFGSGWA WLVVNKEGQL EITSTANQDT PISEGKKPIL ALDVWEHAYY LNYRNVRPNY 

       190        200 
IKAFFEIINW KKVSELYQAA K 

« Hide

References

[1]"Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence."
Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D., Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S., Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.
Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-595 / MGAS315.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014074 Genomic DNA. Translation: AAM79678.1.
RefSeqNP_664875.1. NC_004070.1.

3D structure databases

ProteinModelPortalP0DF72.
SMRP0DF72. Positions 5-197.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM79678; AAM79678; SpyM3_1071.
GeneID1009386.
KEGGspg:SpyM3_1071.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000013583.
KOK04564.
OMADYISAFW.
OrthoDBEOG63NMNT.

Enzyme and pathway databases

BioCycSPYO198466:GJDL-1133-MONOMER.

Family and domain databases

InterProIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERPTHR11404. PTHR11404. 1 hit.
PfamPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFPIRSF000349. SODismutase. 1 hit.
PRINTSPR01703. MNSODISMTASE.
SUPFAMSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSODM_STRP3
AccessionPrimary (citable) accession number: P0DF72
Secondary accession number(s): Q8K6Y8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: November 13, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families