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P0DF72

- SODM_STRP3

UniProt

P0DF72 - SODM_STRP3

Protein

Superoxide dismutase [Mn]

Gene

sodA

Organism
Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.

    Cofactori

    Binds 1 manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi27 – 271ManganeseBy similarity
    Metal bindingi81 – 811ManganeseBy similarity
    Metal bindingi163 – 1631ManganeseBy similarity
    Metal bindingi167 – 1671ManganeseBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. superoxide dismutase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSPYO198466:GJDL-1133-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Mn] (EC:1.15.1.1)
    Gene namesi
    Name:sodA
    Synonyms:sodM
    Ordered Locus Names:SpyM3_1071
    OrganismiStreptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
    Taxonomic identifieri198466 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000564: Chromosome

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 201200Superoxide dismutase [Mn]PRO_0000160102Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP0DF72.
    SMRiP0DF72. Positions 5-197.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000013583.
    KOiK04564.
    OMAiPLPYDYN.
    OrthoDBiEOG63NMNT.

    Family and domain databases

    InterProiIPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view]
    PANTHERiPTHR11404. PTHR11404. 1 hit.
    PfamiPF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000349. SODismutase. 1 hit.
    PRINTSiPR01703. MNSODISMTASE.
    SUPFAMiSSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEiPS00088. SOD_MN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0DF72-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIILPELPY AYDALEPQFD AETMTLHHDK HHATYVANTN AALEKHPEIG    50
    ENLEELLADV TKIPEDIRQA LINNGGGHLN HALFWELLSP EKQDVTSDVA 100
    QAIDDAFGSF DAFKEQFTAA ATGRFGSGWA WLVVNKEGQL EITSTANQDT 150
    PISEGKKPIL ALDVWEHAYY LNYRNVRPNY IKAFFEIINW KKVSELYQAA 200
    K 201
    Length:201
    Mass (Da):22,657
    Last modified:July 27, 2011 - v1
    Checksum:i74F066CA96477050
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014074 Genomic DNA. Translation: AAM79678.1.
    RefSeqiNP_664875.1. NC_004070.1.

    Genome annotation databases

    EnsemblBacteriaiAAM79678; AAM79678; SpyM3_1071.
    GeneIDi1009386.
    KEGGispg:SpyM3_1071.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014074 Genomic DNA. Translation: AAM79678.1 .
    RefSeqi NP_664875.1. NC_004070.1.

    3D structure databases

    ProteinModelPortali P0DF72.
    SMRi P0DF72. Positions 5-197.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM79678 ; AAM79678 ; SpyM3_1071 .
    GeneIDi 1009386.
    KEGGi spg:SpyM3_1071.

    Phylogenomic databases

    HOGENOMi HOG000013583.
    KOi K04564.
    OMAi PLPYDYN.
    OrthoDBi EOG63NMNT.

    Enzyme and pathway databases

    BioCyci SPYO198466:GJDL-1133-MONOMER.

    Family and domain databases

    InterProi IPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view ]
    PANTHERi PTHR11404. PTHR11404. 1 hit.
    Pfami PF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000349. SODismutase. 1 hit.
    PRINTSi PR01703. MNSODISMTASE.
    SUPFAMi SSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEi PS00088. SOD_MN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence."
      Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D., Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S., Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.
      Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-595 / MGAS315.

    Entry informationi

    Entry nameiSODM_STRP3
    AccessioniPrimary (citable) accession number: P0DF72
    Secondary accession number(s): Q8K6Y8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Although found extracellularly, no signal sequence is present. An alternative secretory pathway may be used.Curated

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3