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P0DD62

- PUR5_STRP3

UniProt

P0DD62 - PUR5_STRP3

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPYO198466:GJDL-56-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:SpyM3_0022
OrganismiStreptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Taxonomic identifieri198466 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000564: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148262Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0DD62.
SMRiP0DD62. Positions 15-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229090.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DD62-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEKNAYAKS GVDVEAGYEV VERIKKHVAR TERAGVMGVL GGFGGMFDLS
60 70 80 90 100
KTGVKEPVLV SGTDGVGTKL MLAIKYDKHD TIGQDCVAMC VNDIIAAGAE
110 120 130 140 150
PLYFLDYIAT GKNNPVKLEE VVSGVAEGCV QAGVALIGGE TAEMPGMYGE
160 170 180 190 200
DDYDLAGFAV GVAEKSQIID GSKVKEGDIL LGLASSGIHS NGYSLVRRVF
210 220 230 240 250
ADYTGKELLP ELEGKQLKDV LLEPTRIYVK AALPLIKEEL VNGIGHITGG
260 270 280 290 300
GFIENVPRMF ADDLAAEIDE DKVPVLPIFK ALEKYGDIKH EEMFEIFNMG
310 320 330 340
VGLMLAVSPE NVNRVKELLD EPVYEIGRII KKADASVVIK
Length:340
Mass (Da):36,500
Last modified:July 27, 2011 - v1
Checksum:i4E6B4A75CB1BB1A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014074 Genomic DNA. Translation: AAM78629.1.
RefSeqiNP_663826.1. NC_004070.1.

Genome annotation databases

EnsemblBacteriaiAAM78629; AAM78629; SpyM3_0022.
GeneIDi1008336.
KEGGispg:SpyM3_0022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014074 Genomic DNA. Translation: AAM78629.1 .
RefSeqi NP_663826.1. NC_004070.1.

3D structure databases

ProteinModelPortali P0DD62.
SMRi P0DD62. Positions 15-333.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM78629 ; AAM78629 ; SpyM3_0022 .
GeneIDi 1008336.
KEGGi spg:SpyM3_0022.

Phylogenomic databases

HOGENOMi HOG000229090.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci SPYO198466:GJDL-56-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence."
    Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D., Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S., Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-595 / MGAS315.

Entry informationi

Entry nameiPUR5_STRP3
AccessioniPrimary (citable) accession number: P0DD62
Secondary accession number(s): Q8K8Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3