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P0DC99

- CAPP_STRPQ

UniProt

P0DC99 - CAPP_STRPQ

Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Streptococcus pyogenes serotype M3 (strain SSI-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

    Catalytic activityi

    Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei138 – 1381UniRule annotation
    Active sitei583 – 5831UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbon fixation Source: UniProtKB-HAMAP
    2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Carbon dioxide fixation

    Keywords - Ligandi

    Magnesium

    Enzyme and pathway databases

    BioCyciSPYO193567:GHDO-1485-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
    Short name:
    PEPCUniRule annotation
    Short name:
    PEPCaseUniRule annotation
    Gene namesi
    Name:ppcUniRule annotation
    Ordered Locus Names:SPs1425
    OrganismiStreptococcus pyogenes serotype M3 (strain SSI-1)
    Taxonomic identifieri193567 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002699: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 920920Phosphoenolpyruvate carboxylasePRO_0000411437Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0DC99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PEPCase type 1 family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000238647.
    KOiK01595.
    OrthoDBiEOG6TJ7T8.

    Family and domain databases

    HAMAPiMF_00595. PEPcase_type1.
    InterProiIPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PfamiPF00311. PEPcase. 1 hit.
    [Graphical view]
    PRINTSiPR00150. PEPCARBXLASE.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    PROSITEiPS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0DC99-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLKKLESSN NQTIIAEEVA LLKEMLENIT RRMIGDDAFT VIESIMVLSE    50
    KQDYIELEKV VANISNQEME VISRYFSILP LLINISEDVD LAYEINHQNN 100
    TDTDYLGKLA LTIKDLAGKD NGKDILEQVN VVPVLTAHPT QVQRKTILEL 150
    TTHIHKLLRK YRDAKAGVIN LEKWRQELYR YIEMIMQTDI IREKKLQVKN 200
    EIKNVMQYYD GSLIQAVTKL TTEYKNLAQK HGLELDNPKP ITMGMWIGGD 250
    RDGNPFVTAE TLCLSATVQS EVILNYYIDK LAALYRTFSL SSTLVQPNSE 300
    VERLASLSQD QSIYRGNEPY RRAFHYIQSR LKQTQIQLTN QPAARMSSSV 350
    GLNTSAWSSP ASLENPILAY DSPVDFKADL KAIEQSLLDN GNSALIEGDL 400
    REVMQAVDIF GFFLASIDMR QDSSVQEACV AELLKGANIV DDYSSLSETE 450
    KCDVLLQQLM EEPRTLSSAA VAKSDLLEKE LAIYTTAREL KDKLGEEVIK 500
    QHIISHTESV SDMFELAIML KEVGLVDQQR ARVQIVPLFE TIEDLDNARD 550
    IMAAYLSHDI VKSWIATNRN YQEIMLGYSD SNKDGGYLAS GWTLYKAQNE 600
    LTAIGEEHGV KITFFHGRGG TVGRGGGPSY DAITSQPFGS IKDRIRLTEQ 650
    GEIIENKYGN KDVAYYHLEM LISASINRMV TQMITDPNEI DSFREIMDSI 700
    VADSNTIYRK LVFDNPHFYD YFFEASPIKE VSSLNIGSRP AARKTITEIT 750
    GLRAIPWVFS WSQNRIMFPG WYGVGSAFKR YIDRAQGNLE RLQHMYQTWP 800
    FFHSLLSNVD MVLSKSNMNI AFQYAQLAES QDVRDVFYEI LDEWQLTKNV 850
    ILAIQDHDDL LEDNPSLKHS LKSRLPYFNV LNYIQIELIK RWRNNQLDEN 900
    DEKLIHTTIN GIATGLRNSG 920
    Length:920
    Mass (Da):104,699
    Last modified:July 27, 2011 - v1
    Checksum:iA7837E73861919F7
    GO

    Sequence cautioni

    The sequence BAC64520.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000034 Genomic DNA. Translation: BAC64520.1. Different initiation.
    RefSeqiNP_802687.1. NC_004606.1.

    Genome annotation databases

    EnsemblBacteriaiBAC64520; BAC64520; BAC64520.
    GeneIDi1066580.
    KEGGisps:SPs1425.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000034 Genomic DNA. Translation: BAC64520.1 . Different initiation.
    RefSeqi NP_802687.1. NC_004606.1.

    3D structure databases

    ProteinModelPortali P0DC99.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC64520 ; BAC64520 ; BAC64520 .
    GeneIDi 1066580.
    KEGGi sps:SPs1425.

    Phylogenomic databases

    HOGENOMi HOG000238647.
    KOi K01595.
    OrthoDBi EOG6TJ7T8.

    Enzyme and pathway databases

    BioCyci SPYO193567:GHDO-1485-MONOMER.

    Family and domain databases

    HAMAPi MF_00595. PEPcase_type1.
    InterProi IPR021135. PEP_COase.
    IPR018129. PEP_COase_AS.
    IPR022805. PEP_COase_bac/pln-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    Pfami PF00311. PEPcase. 1 hit.
    [Graphical view ]
    PRINTSi PR00150. PEPCARBXLASE.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    PROSITEi PS00781. PEPCASE_1. 1 hit.
    PS00393. PEPCASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution."
      Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y., Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T., Hayashi H., Hattori M., Hamada S.
      Genome Res. 13:1042-1055(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SSI-1.

    Entry informationi

    Entry nameiCAPP_STRPQ
    AccessioniPrimary (citable) accession number: P0DC99
    Secondary accession number(s): Q8K873
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3