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Protein

Tagatose 1,6-diphosphate aldolase 2

Gene

lacD2

Organism
Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: D-tagatose 6-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tagatose-6-phosphate kinase (lacC)
  2. Tagatose 1,6-diphosphate aldolase 1 (lacD1), Tagatose 1,6-diphosphate aldolase 2 (lacD2)
This subpathway is part of the pathway D-tagatose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate, the pathway D-tagatose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lactose metabolism

Enzyme and pathway databases

BioCyciSPYO198466:GJDL-1738-MONOMER.
UniPathwayiUPA00704; UER00716.

Names & Taxonomyi

Protein namesi
Recommended name:
Tagatose 1,6-diphosphate aldolase 2 (EC:4.1.2.40)
Alternative name(s):
D-tagatose-1,6-bisphosphate aldolase 2
Tagatose-bisphosphate aldolase 2
Gene namesi
Name:lacD2
Synonyms:lacD.2
Ordered Locus Names:SpyM3_1656
OrganismiStreptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Taxonomic identifieri198466 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000564 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Tagatose 1,6-diphosphate aldolase 2PRO_0000203966Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0DC16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldolase LacD family.Curated

Phylogenomic databases

HOGENOMiHOG000241518.
KOiK01635.
OMAiRIGDECR.
OrthoDBiEOG6SR92W.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00734. LacD.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR005927. Tag_1.6-dipho_adolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01232. lacD. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DC16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITLTENKR KSMEKLSVDG VISALAFDQR GALKRMMAQH QTKEPTVEQI
60 70 80 90 100
EELKSLVSEE LTPFASSILL DPEYGLPASR VRSEEAGLLL AYEKTGYDAT
110 120 130 140 150
TTSRLPDCLD VWSAKRIKEA GAEAVKFLIY YDIDGGQDVN EQKKAYIERI
160 170 180 190 200
GSECRAEDIP FYLEILTYDE KIADNASPEF AKVKAHKVNE AMKVFSKERF
210 220 230 240 250
GVDVLKVEVP VNMKFVEGFA DGEILFTKEE AAQAFRDQEA STDLPYIYLS
260 270 280 290 300
AGVSAKLFQD TLVFAAESGA KFNGVLCGRA TWAGSVKVYI EEGPQAAREW
310 320
LRTEGFKNID ELNKVLDKTA SPWTEKM
Length:327
Mass (Da):36,533
Last modified:July 27, 2011 - v1
Checksum:i41ADAB7B6C7597DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014074 Genomic DNA. Translation: AAM80263.1.
RefSeqiWP_011055003.1. NC_004070.1.

Genome annotation databases

EnsemblBacteriaiAAM80263; AAM80263; SpyM3_1656.
KEGGispg:SpyM3_1656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014074 Genomic DNA. Translation: AAM80263.1.
RefSeqiWP_011055003.1. NC_004070.1.

3D structure databases

ProteinModelPortaliP0DC16.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM80263; AAM80263; SpyM3_1656.
KEGGispg:SpyM3_1656.

Phylogenomic databases

HOGENOMiHOG000241518.
KOiK01635.
OMAiRIGDECR.
OrthoDBiEOG6SR92W.

Enzyme and pathway databases

UniPathwayiUPA00704; UER00716.
BioCyciSPYO198466:GJDL-1738-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00734. LacD.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR005927. Tag_1.6-dipho_adolase.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01232. lacD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence."
    Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D., Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S., Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-595 / MGAS315.

Entry informationi

Entry nameiLACD2_STRP3
AccessioniPrimary (citable) accession number: P0DC16
Secondary accession number(s): Q8K5U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.