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Protein

Galactose-6-phosphate isomerase subunit LacA 1

Gene

lacA1

Organism
Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-galactose 6-phosphate = D-tagatose 6-phosphate.UniRule annotation

Pathwayi: D-galactose 6-phosphate degradation

This protein is involved in step 1 of the subpathway that synthesizes D-tagatose 6-phosphate from D-galactose 6-phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Galactose-6-phosphate isomerase subunit LacB 2 (lacB2), Galactose-6-phosphate isomerase subunit LacA 1 (lacA1), Galactose-6-phosphate isomerase subunit LacA 2 (lacA2), Galactose-6-phosphate isomerase subunit LacB 1 (lacB1)
This subpathway is part of the pathway D-galactose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-tagatose 6-phosphate from D-galactose 6-phosphate, the pathway D-galactose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processLactose metabolism

Enzyme and pathway databases

UniPathwayiUPA00702; UER00714.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-6-phosphate isomerase subunit LacA 1UniRule annotation (EC:5.3.1.26UniRule annotation)
Gene namesi
Name:lacA1UniRule annotation
Synonyms:lacA.1
Ordered Locus Names:SpyM3_1485
OrganismiStreptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Taxonomic identifieri198466 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000564 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002081281 – 141Galactose-6-phosphate isomerase subunit LacA 1Add BLAST141

Interactioni

Subunit structurei

Heteromultimeric protein consisting of LacA and LacB.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP0DC04.
SMRiP0DC04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LacAB/RpiB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000226301.
KOiK01819.
OMAiGFVTGKY.

Family and domain databases

Gene3Di3.40.1400.10. 1 hit.
HAMAPiMF_01555. LacA. 1 hit.
InterProiView protein in InterPro
IPR004783. LacA.
IPR003500. RpiB_LacA_LacB.
PANTHERiPTHR30345. PTHR30345. 1 hit.
PfamiView protein in Pfam
PF02502. LacAB_rpiB. 1 hit.
PIRSFiPIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAMiSSF89623. SSF89623. 1 hit.
TIGRFAMsiTIGR01118. lacA. 1 hit.
TIGR00689. rpiB_lacA_lacB. 1 hit.

Sequencei

Sequence statusi: Complete.

P0DC04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIILGADAH GNALKELIKS FLQEESYDII DVTDINSDFI DNTLAVAKAV
60 70 80 90 100
NEAEGRLGIM VDAYGAGPFM VATKLKGMVA AEVSDERSAY MTRGHNNARM
110 120 130 140
ITIGAEIVGP ELAKNIVKGF VTGPYDGGRH QIRVDMLNKM A
Length:141
Mass (Da):15,156
Last modified:July 27, 2011 - v1
Checksum:iA6BF15FF1B6889A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014074 Genomic DNA. Translation: AAM80092.1.
RefSeqiWP_011054921.1. NC_004070.1.

Genome annotation databases

EnsemblBacteriaiAAM80092; AAM80092; SpyM3_1485.
KEGGispg:SpyM3_1485.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLACA1_STRP3
AccessioniPrimary (citable) accession number: P0DC04
Secondary accession number(s): Q79YA2, Q8K651
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: June 7, 2017
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families