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P0DB91 (GUAC_STRPQ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GMP reductase

EC=1.7.1.7
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase
Short name=Guanosine monophosphate reductase
Gene names
Name:guaC
Ordered Locus Names:SPs0992
OrganismStreptococcus pyogenes serotype M3 (strain SSI-1) [Complete proteome] [HAMAP]
Taxonomic identifier193567 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP-Rule MF_01511

Catalytic activity

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP-Rule MF_01511

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentGMP reductase complex

Inferred from electronic annotation. Source: UniProtKB-EC

   Molecular_functionGMP reductase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327GMP reductase HAMAP-Rule MF_01511
PRO_0000411383

Regions

Nucleotide binding205 – 22824NADP By similarity

Sites

Active site1761Thioimidate intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P0DB91 [UniParc].

Last modified July 27, 2011. Version 1.
Checksum: 038D2B9F9151AB93

FASTA32735,929
        10         20         30         40         50         60 
MFNDIPVFDY EDIQLIPNKC IITSRSQADT SVTLGKYQFK LPVIPANMQT IIDETIAEQL 

        70         80         90        100        110        120 
AKEGYFYIMH RFDEDSRKPF IKRMHEQGLI ASISVGVKAC EYEFVTSLKE DAPEFITIDI 

       130        140        150        160        170        180 
AHGHANSVID MIKHIKTELP ETFVIAGNVG TPEAVRELEN AGADATKVGI GPGKVCITKV 

       190        200        210        220        230        240 
KTGFGTGGWQ LAALRWCAKA ARKPIIADGG IRTHGDIAKS IRFGASMVMI GSLFAGHIES 

       250        260        270        280        290        300 
PGKTVEVDGE TFKEYYGSAS EYQKGEHKNV EGKKILLPTK GHLSDTLTEM QQDLQSSISY 

       310        320 
AGGKDLDSLR HVDYVIVKNS IWNGDSI 

« Hide

References

[1]"Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution."
Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y., Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T., Hayashi H., Hattori M., Hamada S.
Genome Res. 13:1042-1055(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SSI-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000034 Genomic DNA. Translation: BAC64087.1.
RefSeqNP_802254.1. NC_004606.1.

3D structure databases

ProteinModelPortalP0DB91.
SMRP0DB91. Positions 7-322.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC64087; BAC64087; BAC64087.
GeneID1066293.
KEGGsps:SPs0992.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000165753.
KOK00364.
OMAPDYITID.
OrthoDBEOG6GTZPV.

Enzyme and pathway databases

BioCycSPYO193567:GHDO-1048-MONOMER.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01511. GMP_reduct_type2.
InterProIPR013785. Aldolase_TIM.
IPR005994. GMP_reduct2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsTIGR01306. GMP_reduct_2. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAC_STRPQ
AccessionPrimary (citable) accession number: P0DB91
Secondary accession number(s): Q8K7I6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: February 19, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families