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P0DB32

- GLMS_STRP3

UniProt

P0DB32 - GLMS_STRP3

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei599 – 5991For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciSPYO198466:GJDL-971-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:SpyM3_0910
OrganismiStreptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Taxonomic identifieri198466 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000564: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 604603Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135394Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP0DB32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 218217Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini284 – 423140SIS 1UniRule annotationAdd
BLAST
Domaini452 – 594143SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

HOGENOMiHOG000258896.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DB32-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGVVGN RNATDILMQG LEKLEYRGYD SAGIFVANAN QTNLIKSVGR
60 70 80 90 100
IADLRAKIGI DVAGSTGIGH TRWATHGQST EDNAHPHTSQ TGRFVLVHNG
110 120 130 140 150
VIENYLHIKT EFLAGHDFKG QTDTEIAVHL IGKFVEEDKL SVLEAFKKAL
160 170 180 190 200
SIIEGSYAFA LMDSQATDTI YVAKNKSPLL IGLGEGYNMV CSDAMAMIRE
210 220 230 240 250
TSEFMEIHDK ELVILTKDKV TVTDYDGKEL IRDSYTAELD LSDIGKGTYP
260 270 280 290 300
FYMLKEIDEQ PTVMRQLIST YADETGNVQV DPAIITSIQE ADRLYILAAG
310 320 330 340 350
TSYHAGFATK NMLEQLTDTP VELGVASEWG YHMPLLSKKP MFILLSQSGE
360 370 380 390 400
TADSRQVLVK ANAMGIPSLT VTNVPGSTLS RESTYTMLIH AGPEIAVAST
410 420 430 440 450
KAYTAQIAAL AFLAKAVGEA NGKQEALDFN LVHELSLVAQ SIEATLSEKD
460 470 480 490 500
LVAEKVQALL TTTRNAFYIG RGNDYYVAME AALKLKEISY IQCEGFAAGE
510 520 530 540 550
LKHGTISLIE EDTPVIALIS SSQLVASHTR GNIQEVAARG AHVLTVVEEG
560 570 580 590 600
LDREGDDIIV NKVHPFLAPI AMVIPTQLIA YYASLQRGLD VDKPRNLAKA

VTVE
Length:604
Mass (Da):65,623
Last modified:July 27, 2011 - v1
Checksum:i4D36F26D471EEABF
GO

Sequence cautioni

The sequence AAM79517.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014074 Genomic DNA. Translation: AAM79517.1. Different initiation.
RefSeqiNP_664714.1. NC_004070.1.

Genome annotation databases

EnsemblBacteriaiAAM79517; AAM79517; SpyM3_0910.
GeneIDi1009225.
KEGGispg:SpyM3_0910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014074 Genomic DNA. Translation: AAM79517.1 . Different initiation.
RefSeqi NP_664714.1. NC_004070.1.

3D structure databases

ProteinModelPortali P0DB32.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM79517 ; AAM79517 ; SpyM3_0910 .
GeneIDi 1009225.
KEGGi spg:SpyM3_0910.

Phylogenomic databases

HOGENOMi HOG000258896.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci SPYO198466:GJDL-971-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence."
    Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D., Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S., Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-595 / MGAS315.

Entry informationi

Entry nameiGLMS_STRP3
AccessioniPrimary (citable) accession number: P0DB32
Secondary accession number(s): Q878N9, Q8K7A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3