SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0CZ58

- ALF_STRP3

UniProt

P0CZ58 - ALF_STRP3

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Fructose-bisphosphate aldolase
Gene
fba, SpyM3_1630
Organism
Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis By similarity.

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501Glyceraldehyde 3-phosphate By similarity
Active sitei85 – 851Proton donor By similarity
Metal bindingi86 – 861Zinc 1; catalytic By similarity
Metal bindingi106 – 1061Zinc 2 By similarity
Metal bindingi136 – 1361Zinc 2 By similarity
Metal bindingi178 – 1781Zinc 1; catalytic By similarity
Binding sitei179 – 1791Dihydroxyacetone phosphate; via amide nitrogen By similarity
Metal bindingi208 – 2081Zinc 1; catalytic By similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fructose 1,6-bisphosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSPYO198466:GJDL-1705-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Ordered Locus Names:SpyM3_1630
OrganismiStreptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Taxonomic identifieri198466 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000564: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 293292Fructose-bisphosphate aldolase
PRO_0000178748Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0CZ58.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni209 – 2113Dihydroxyacetone phosphate binding By similarity
Regioni230 – 2334Dihydroxyacetone phosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000227793.
KOiK01624.
OMAiCTTRYEA.
OrthoDBiEOG6HXJ7B.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CZ58-1 [UniParc]FASTAAdd to Basket

« Hide

MAIVSAEKFV QAARKNGYAV GGFNTNNLEW TQAILRAAEA KQAPVLIQTS    50
MGAAKYMGGY KVCQSLITNL VESMGITVPV AIHLDHGHYE DALECIEVGY 100
TSIMFDGSHL PVEENLAKTA EVVKIAHAKG VSVEAEVGTI GGEEDGIIGK 150
GELAPIEDAK AMVETGIDFL AAGIGNIHGP YPENWEGLAL DHLEKLTAAV 200
PGFPIVLHGG SGIPDDQIKE AIRLGVAKVN VNTESQIAFS NATREFARNY 250
EANEAEYDGK KLFDPRKFLA PGMKAVQGAV EERIDVFGSA NKA 293
Length:293
Mass (Da):31,207
Last modified:July 27, 2011 - v1
Checksum:iB61B3A7C25879D70
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014074 Genomic DNA. Translation: AAM80237.1.
RefSeqiNP_665434.1. NC_004070.1.
WP_011054987.1. NC_004070.1.

Genome annotation databases

EnsemblBacteriaiAAM80237; AAM80237; SpyM3_1630.
GeneIDi1009945.
KEGGispg:SpyM3_1630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014074 Genomic DNA. Translation: AAM80237.1 .
RefSeqi NP_665434.1. NC_004070.1.
WP_011054987.1. NC_004070.1.

3D structure databases

ProteinModelPortali P0CZ58.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM80237 ; AAM80237 ; SpyM3_1630 .
GeneIDi 1009945.
KEGGi spg:SpyM3_1630.

Phylogenomic databases

HOGENOMi HOG000227793.
KOi K01624.
OMAi CTTRYEA.
OrthoDBi EOG6HXJ7B.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
BioCyci SPYO198466:GJDL-1705-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence."
    Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D., Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S., Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-595 / MGAS315.

Entry informationi

Entry nameiALF_STRP3
AccessioniPrimary (citable) accession number: P0CZ58
Secondary accession number(s): Q8K5W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi