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P0CZ01

- HYSA_PROAC

UniProt

P0CZ01 - HYSA_PROAC

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Protein
Hyaluronate lyase
Gene
PPA0380
Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Cleaves hyaluronate chains at a beta-D-GalNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine.

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. hyaluronate lyase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciPACN267747:GHO9-377-MONOMER.
BRENDAi4.2.2.1. 5029.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronate lyase (EC:4.2.2.1)
Alternative name(s):
Hyaluronidase
Short name:
HYase
Gene namesi
Ordered Locus Names:PPA0380
OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000000603: Chromosome

Subcellular locationi

Secretedcell wall By similarity

GO - Cellular componenti

  1. cell wall Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Tat-type signal By similarity
Add
BLAST
Chaini33 – 813781Hyaluronate lyase
PRO_0000024930Add
BLAST

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP0CZ01.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000243554.
KOiK01727.
OMAiENEWASR.
OrthoDBiEOG6GBM67.

Family and domain databases

Gene3Di1.50.10.100. 1 hit.
2.60.220.10. 1 hit.
2.70.98.10. 1 hit.
InterProiIPR008929. Chondroitin_lyas.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR011071. Lyase_8-like_C.
IPR012970. Lyase_8_alpha_N.
IPR004103. Lyase_8_C.
IPR003159. Lyase_8_central_dom.
IPR012329. Lyase_8_N.
IPR006311. TAT_signal.
[Graphical view]
PfamiPF02278. Lyase_8. 1 hit.
PF02884. Lyase_8_C. 1 hit.
PF08124. Lyase_8_N. 1 hit.
[Graphical view]
SUPFAMiSSF48230. SSF48230. 1 hit.
SSF49863. SSF49863. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CZ01-1 [UniParc]FASTAAdd to Basket

« Hide

MFGTPSRRTF LTASALSAMA LAASPTVTDA IAAPGPDSWS ALCERWIDII    50
TGRRAARTSD PRARAIIAKT DRKVAEILTD LVSGSSRQTV LISADLRKEQ 100
SPFITKTARA IESMACAWAT PGSSYHKDPE ILSACIEGLR DFCRLRYNPS 150
QDEYGNWWDW EDGASRAVAD VMCILHDVLP PEVMSAAAAG IDHFIPDPWF 200
QQPASVKPTA NPVQPVVSTG ANRMDLTRAV MCRSIATGDE KRLRHAVDGL 250
PDAWRVTTEG DGFRADGGFI QHSHIPYTGG YGDVLFSGLA MLFPLVSGMR 300
FDIVESARKA FHDQVERGFI PVMYNGQILD DVRGRSISRI NESAAMHGIS 350
IARAMLMMAD ALPTHRAEQW RGIVHGWMAR NTFDHLSEPS TLVDISLFDA 400
AAKARPVPES STPSYFASMD RLVHRTADWL ITVSNCSDRI AWYEYGNGEN 450
EWASRTSQGM RYLLLPGDMG QYEDGYWATV DYSAPTGTTV DSTPLKRAVG 500
ASWAAKTPTN EWSGGLASGS WSAAASHITS QDSALKARRL WVGLKDAMVE 550
LTTDVTTDAS RAITVVEHRK VASSSTKLLV DGNRVSSATS FQNPRWAHLD 600
GVGGYVFATD TDLSADVATR KGTWIDVNPS RKVKGADEVI ERAYASLHVT 650
HHDRPVAWAL LPTASRSHTM ALATRPGVEP FTVLRNDATV QAVRSAGALL 700
TKDPTVVTTL AFWKPATCGG VAVNRPALVQ TRESANQMEV VIVEPTQKRG 750
SLTVTIEGSW KVKTADSHVD VSCENAAGTL HVDTAGLGGQ SVRVTLARQV 800
TQTPSGGGRH DRA 813
Length:813
Mass (Da):88,130
Last modified:June 28, 2011 - v1
Checksum:i0C4316E7890D4D1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017283 Genomic DNA. Translation: AAT82132.1.
RefSeqiYP_055090.1. NC_006085.1.

Genome annotation databases

EnsemblBacteriaiAAT82132; AAT82132; PPA0380.
GeneIDi2932015.
KEGGipac:PPA0380.
PATRICi23035411. VBIProAcn64440_0390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017283 Genomic DNA. Translation: AAT82132.1 .
RefSeqi YP_055090.1. NC_006085.1.

3D structure databases

ProteinModelPortali P0CZ01.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT82132 ; AAT82132 ; PPA0380 .
GeneIDi 2932015.
KEGGi pac:PPA0380.
PATRICi 23035411. VBIProAcn64440_0390.

Phylogenomic databases

HOGENOMi HOG000243554.
KOi K01727.
OMAi ENEWASR.
OrthoDBi EOG6GBM67.

Enzyme and pathway databases

BioCyci PACN267747:GHO9-377-MONOMER.
BRENDAi 4.2.2.1. 5029.

Family and domain databases

Gene3Di 1.50.10.100. 1 hit.
2.60.220.10. 1 hit.
2.70.98.10. 1 hit.
InterProi IPR008929. Chondroitin_lyas.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR011071. Lyase_8-like_C.
IPR012970. Lyase_8_alpha_N.
IPR004103. Lyase_8_C.
IPR003159. Lyase_8_central_dom.
IPR012329. Lyase_8_N.
IPR006311. TAT_signal.
[Graphical view ]
Pfami PF02278. Lyase_8. 1 hit.
PF02884. Lyase_8_C. 1 hit.
PF08124. Lyase_8_N. 1 hit.
[Graphical view ]
SUPFAMi SSF48230. SSF48230. 1 hit.
SSF49863. SSF49863. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEi PS51318. TAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
    Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
    Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KPA171202 / DSM 16379.

Entry informationi

Entry nameiHYSA_PROAC
AccessioniPrimary (citable) accession number: P0CZ01
Secondary accession number(s): Q59634, Q6AAT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 14, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi