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Protein

Hyaluronate lyase

Gene

PPA0380

Organism
Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Protein family/group databases

CAZyiPL8 Polysaccharide Lyase Family 8

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronate lyase (EC:4.2.2.1)
Alternative name(s):
Hyaluronidase
Short name:
HYase
Gene namesi
Ordered Locus Names:PPA0380
OrganismiCutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaeCutibacterium
Proteomesi
  • UP000000603 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Tat-type signalPROSITE-ProRule annotationAdd BLAST32
ChainiPRO_000002493033 – 813Hyaluronate lyaseAdd BLAST781

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Proteomic databases

PRIDEiP0CZ01

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi267747.PPA0380

Structurei

3D structure databases

ProteinModelPortaliP0CZ01
SMRiP0CZ01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polysaccharide lyase 8 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106AM8 Bacteria
ENOG410XTFC LUCA
HOGENOMiHOG000243554
KOiK01727
OMAiRYYQDET

Family and domain databases

Gene3Di1.50.10.100, 1 hit
2.60.220.10, 1 hit
2.70.98.10, 1 hit
InterProiView protein in InterPro
IPR008929 Chondroitin_lyas
IPR011013 Gal_mutarotase_sf_dom
IPR014718 GH-type_carb-bd
IPR038970 Lyase_8
IPR011071 Lyase_8-like_C
IPR012970 Lyase_8_alpha_N
IPR004103 Lyase_8_C
IPR003159 Lyase_8_central_dom
IPR006311 TAT_signal
PANTHERiPTHR38481 PTHR38481, 1 hit
PfamiView protein in Pfam
PF02278 Lyase_8, 1 hit
PF02884 Lyase_8_C, 1 hit
PF08124 Lyase_8_N, 1 hit
SUPFAMiSSF48230 SSF48230, 1 hit
SSF49863 SSF49863, 1 hit
SSF74650 SSF74650, 1 hit
PROSITEiView protein in PROSITE
PS51318 TAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CZ01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGTPSRRTF LTASALSAMA LAASPTVTDA IAAPGPDSWS ALCERWIDII
60 70 80 90 100
TGRRAARTSD PRARAIIAKT DRKVAEILTD LVSGSSRQTV LISADLRKEQ
110 120 130 140 150
SPFITKTARA IESMACAWAT PGSSYHKDPE ILSACIEGLR DFCRLRYNPS
160 170 180 190 200
QDEYGNWWDW EDGASRAVAD VMCILHDVLP PEVMSAAAAG IDHFIPDPWF
210 220 230 240 250
QQPASVKPTA NPVQPVVSTG ANRMDLTRAV MCRSIATGDE KRLRHAVDGL
260 270 280 290 300
PDAWRVTTEG DGFRADGGFI QHSHIPYTGG YGDVLFSGLA MLFPLVSGMR
310 320 330 340 350
FDIVESARKA FHDQVERGFI PVMYNGQILD DVRGRSISRI NESAAMHGIS
360 370 380 390 400
IARAMLMMAD ALPTHRAEQW RGIVHGWMAR NTFDHLSEPS TLVDISLFDA
410 420 430 440 450
AAKARPVPES STPSYFASMD RLVHRTADWL ITVSNCSDRI AWYEYGNGEN
460 470 480 490 500
EWASRTSQGM RYLLLPGDMG QYEDGYWATV DYSAPTGTTV DSTPLKRAVG
510 520 530 540 550
ASWAAKTPTN EWSGGLASGS WSAAASHITS QDSALKARRL WVGLKDAMVE
560 570 580 590 600
LTTDVTTDAS RAITVVEHRK VASSSTKLLV DGNRVSSATS FQNPRWAHLD
610 620 630 640 650
GVGGYVFATD TDLSADVATR KGTWIDVNPS RKVKGADEVI ERAYASLHVT
660 670 680 690 700
HHDRPVAWAL LPTASRSHTM ALATRPGVEP FTVLRNDATV QAVRSAGALL
710 720 730 740 750
TKDPTVVTTL AFWKPATCGG VAVNRPALVQ TRESANQMEV VIVEPTQKRG
760 770 780 790 800
SLTVTIEGSW KVKTADSHVD VSCENAAGTL HVDTAGLGGQ SVRVTLARQV
810
TQTPSGGGRH DRA
Length:813
Mass (Da):88,130
Last modified:June 28, 2011 - v1
Checksum:i0C4316E7890D4D1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA Translation: AAT82132.1

Genome annotation databases

EnsemblBacteriaiAAT82132; AAT82132; PPA0380
KEGGipac:PPA0380

Similar proteinsi

Entry informationi

Entry nameiHYSA_CUTAK
AccessioniPrimary (citable) accession number: P0CZ01
Secondary accession number(s): Q59634, Q6AAT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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