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P0CZ01

- HYSA_PROAC

UniProt

P0CZ01 - HYSA_PROAC

Protein

Hyaluronate lyase

Gene

PPA0380

Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Cleaves hyaluronate chains at a beta-D-GalNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine.

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. hyaluronate lyase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Enzyme and pathway databases

    BioCyciPACN267747:GHO9-377-MONOMER.
    BRENDAi4.2.2.1. 5029.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronate lyase (EC:4.2.2.1)
    Alternative name(s):
    Hyaluronidase
    Short name:
    HYase
    Gene namesi
    Ordered Locus Names:PPA0380
    OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)
    Taxonomic identifieri267747 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
    ProteomesiUP000000603: Chromosome

    Subcellular locationi

    Secretedcell wall By similarity

    GO - Cellular componenti

    1. cell wall Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell wall, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Tat-type signalPROSITE-ProRule annotationAdd
    BLAST
    Chaini33 – 813781Hyaluronate lyasePRO_0000024930Add
    BLAST

    Post-translational modificationi

    Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP0CZ01.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polysaccharide lyase 8 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOGENOMiHOG000243554.
    KOiK01727.
    OMAiENEWASR.
    OrthoDBiEOG6GBM67.

    Family and domain databases

    Gene3Di1.50.10.100. 1 hit.
    2.60.220.10. 1 hit.
    2.70.98.10. 1 hit.
    InterProiIPR008929. Chondroitin_lyas.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR011071. Lyase_8-like_C.
    IPR012970. Lyase_8_alpha_N.
    IPR004103. Lyase_8_C.
    IPR003159. Lyase_8_central_dom.
    IPR012329. Lyase_8_N.
    IPR006311. TAT_signal.
    [Graphical view]
    PfamiPF02278. Lyase_8. 1 hit.
    PF02884. Lyase_8_C. 1 hit.
    PF08124. Lyase_8_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF48230. SSF48230. 1 hit.
    SSF49863. SSF49863. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEiPS51318. TAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0CZ01-1 [UniParc]FASTAAdd to Basket

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    MFGTPSRRTF LTASALSAMA LAASPTVTDA IAAPGPDSWS ALCERWIDII    50
    TGRRAARTSD PRARAIIAKT DRKVAEILTD LVSGSSRQTV LISADLRKEQ 100
    SPFITKTARA IESMACAWAT PGSSYHKDPE ILSACIEGLR DFCRLRYNPS 150
    QDEYGNWWDW EDGASRAVAD VMCILHDVLP PEVMSAAAAG IDHFIPDPWF 200
    QQPASVKPTA NPVQPVVSTG ANRMDLTRAV MCRSIATGDE KRLRHAVDGL 250
    PDAWRVTTEG DGFRADGGFI QHSHIPYTGG YGDVLFSGLA MLFPLVSGMR 300
    FDIVESARKA FHDQVERGFI PVMYNGQILD DVRGRSISRI NESAAMHGIS 350
    IARAMLMMAD ALPTHRAEQW RGIVHGWMAR NTFDHLSEPS TLVDISLFDA 400
    AAKARPVPES STPSYFASMD RLVHRTADWL ITVSNCSDRI AWYEYGNGEN 450
    EWASRTSQGM RYLLLPGDMG QYEDGYWATV DYSAPTGTTV DSTPLKRAVG 500
    ASWAAKTPTN EWSGGLASGS WSAAASHITS QDSALKARRL WVGLKDAMVE 550
    LTTDVTTDAS RAITVVEHRK VASSSTKLLV DGNRVSSATS FQNPRWAHLD 600
    GVGGYVFATD TDLSADVATR KGTWIDVNPS RKVKGADEVI ERAYASLHVT 650
    HHDRPVAWAL LPTASRSHTM ALATRPGVEP FTVLRNDATV QAVRSAGALL 700
    TKDPTVVTTL AFWKPATCGG VAVNRPALVQ TRESANQMEV VIVEPTQKRG 750
    SLTVTIEGSW KVKTADSHVD VSCENAAGTL HVDTAGLGGQ SVRVTLARQV 800
    TQTPSGGGRH DRA 813
    Length:813
    Mass (Da):88,130
    Last modified:June 28, 2011 - v1
    Checksum:i0C4316E7890D4D1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017283 Genomic DNA. Translation: AAT82132.1.
    RefSeqiYP_055090.1. NC_006085.1.

    Genome annotation databases

    EnsemblBacteriaiAAT82132; AAT82132; PPA0380.
    GeneIDi2932015.
    KEGGipac:PPA0380.
    PATRICi23035411. VBIProAcn64440_0390.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017283 Genomic DNA. Translation: AAT82132.1 .
    RefSeqi YP_055090.1. NC_006085.1.

    3D structure databases

    ProteinModelPortali P0CZ01.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT82132 ; AAT82132 ; PPA0380 .
    GeneIDi 2932015.
    KEGGi pac:PPA0380.
    PATRICi 23035411. VBIProAcn64440_0390.

    Phylogenomic databases

    HOGENOMi HOG000243554.
    KOi K01727.
    OMAi ENEWASR.
    OrthoDBi EOG6GBM67.

    Enzyme and pathway databases

    BioCyci PACN267747:GHO9-377-MONOMER.
    BRENDAi 4.2.2.1. 5029.

    Family and domain databases

    Gene3Di 1.50.10.100. 1 hit.
    2.60.220.10. 1 hit.
    2.70.98.10. 1 hit.
    InterProi IPR008929. Chondroitin_lyas.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR011071. Lyase_8-like_C.
    IPR012970. Lyase_8_alpha_N.
    IPR004103. Lyase_8_C.
    IPR003159. Lyase_8_central_dom.
    IPR012329. Lyase_8_N.
    IPR006311. TAT_signal.
    [Graphical view ]
    Pfami PF02278. Lyase_8. 1 hit.
    PF02884. Lyase_8_C. 1 hit.
    PF08124. Lyase_8_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48230. SSF48230. 1 hit.
    SSF49863. SSF49863. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEi PS51318. TAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
      Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
      Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KPA171202 / DSM 16379.

    Entry informationi

    Entry nameiHYSA_PROAC
    AccessioniPrimary (citable) accession number: P0CZ01
    Secondary accession number(s): Q59634, Q6AAT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3