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P0CZ01 (HYSA_PROAC) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hyaluronate lyase

EC=4.2.2.1
Alternative name(s):
Hyaluronidase
Short name=HYase
Gene names
Ordered Locus Names:PPA0380
OrganismPropionibacterium acnes (strain KPA171202 / DSM 16379) [Complete proteome] [HAMAP]
Taxonomic identifier267747 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium

Protein attributes

Sequence length813 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Cleaves hyaluronate chains at a beta-D-GalNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine.

Subunit structure

Monomer By similarity.

Subcellular location

Secretedcell wall By similarity.

Post-translational modification

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Sequence similarities

Belongs to the polysaccharide lyase 8 family.

Ontologies

Keywords
   Cellular componentCell wall
Secreted
   DomainSignal
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcell wall

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

hyaluronate lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232Tat-type signal By similarity
Chain33 – 813781Hyaluronate lyase
PRO_0000024930

Sequences

Sequence LengthMass (Da)Tools
P0CZ01 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: 0C4316E7890D4D1D

FASTA81388,130
        10         20         30         40         50         60 
MFGTPSRRTF LTASALSAMA LAASPTVTDA IAAPGPDSWS ALCERWIDII TGRRAARTSD 

        70         80         90        100        110        120 
PRARAIIAKT DRKVAEILTD LVSGSSRQTV LISADLRKEQ SPFITKTARA IESMACAWAT 

       130        140        150        160        170        180 
PGSSYHKDPE ILSACIEGLR DFCRLRYNPS QDEYGNWWDW EDGASRAVAD VMCILHDVLP 

       190        200        210        220        230        240 
PEVMSAAAAG IDHFIPDPWF QQPASVKPTA NPVQPVVSTG ANRMDLTRAV MCRSIATGDE 

       250        260        270        280        290        300 
KRLRHAVDGL PDAWRVTTEG DGFRADGGFI QHSHIPYTGG YGDVLFSGLA MLFPLVSGMR 

       310        320        330        340        350        360 
FDIVESARKA FHDQVERGFI PVMYNGQILD DVRGRSISRI NESAAMHGIS IARAMLMMAD 

       370        380        390        400        410        420 
ALPTHRAEQW RGIVHGWMAR NTFDHLSEPS TLVDISLFDA AAKARPVPES STPSYFASMD 

       430        440        450        460        470        480 
RLVHRTADWL ITVSNCSDRI AWYEYGNGEN EWASRTSQGM RYLLLPGDMG QYEDGYWATV 

       490        500        510        520        530        540 
DYSAPTGTTV DSTPLKRAVG ASWAAKTPTN EWSGGLASGS WSAAASHITS QDSALKARRL 

       550        560        570        580        590        600 
WVGLKDAMVE LTTDVTTDAS RAITVVEHRK VASSSTKLLV DGNRVSSATS FQNPRWAHLD 

       610        620        630        640        650        660 
GVGGYVFATD TDLSADVATR KGTWIDVNPS RKVKGADEVI ERAYASLHVT HHDRPVAWAL 

       670        680        690        700        710        720 
LPTASRSHTM ALATRPGVEP FTVLRNDATV QAVRSAGALL TKDPTVVTTL AFWKPATCGG 

       730        740        750        760        770        780 
VAVNRPALVQ TRESANQMEV VIVEPTQKRG SLTVTIEGSW KVKTADSHVD VSCENAAGTL 

       790        800        810 
HVDTAGLGGQ SVRVTLARQV TQTPSGGGRH DRA 

« Hide

References

[1]"The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KPA171202 / DSM 16379.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017283 Genomic DNA. Translation: AAT82132.1.
RefSeqYP_055090.1. NC_006085.1.

3D structure databases

ProteinModelPortalP0CZ01.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAT82132; AAT82132; PPA0380.
GeneID2932015.
KEGGpac:PPA0380.
PATRIC23035411. VBIProAcn64440_0390.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000243554.
KOK01727.
OMAHAKDYSA.
OrthoDBEOG6GBM67.

Enzyme and pathway databases

BioCycPACN267747:GHO9-377-MONOMER.
BRENDA4.2.2.1. 5029.

Family and domain databases

Gene3D1.50.10.100. 1 hit.
2.60.220.10. 1 hit.
2.70.98.10. 1 hit.
InterProIPR008929. Chondroitin_lyas.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR011071. Lyase_8-like_C.
IPR012970. Lyase_8_alpha_N.
IPR004103. Lyase_8_C.
IPR003159. Lyase_8_central_dom.
IPR012329. Lyase_8_N.
IPR006311. TAT_signal.
[Graphical view]
PfamPF02278. Lyase_8. 1 hit.
PF02884. Lyase_8_C. 1 hit.
PF08124. Lyase_8_N. 1 hit.
[Graphical view]
SUPFAMSSF48230. SSF48230. 1 hit.
SSF49863. SSF49863. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEPS51318. TAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHYSA_PROAC
AccessionPrimary (citable) accession number: P0CZ01
Secondary accession number(s): Q59634, Q6AAT4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 13, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families