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P0CZ01

- HYSA_PROAC

UniProt

P0CZ01 - HYSA_PROAC

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Protein

Hyaluronate lyase

Gene

PPA0380

Organism
Propionibacterium acnes (strain KPA171202 / DSM 16379)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Cleaves hyaluronate chains at a beta-D-GalNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine.

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. hyaluronate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciPACN267747:GHO9-377-MONOMER.
BRENDAi4.2.2.1. 5029.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronate lyase (EC:4.2.2.1)
Alternative name(s):
Hyaluronidase
Short name:
HYase
Gene namesi
Ordered Locus Names:PPA0380
OrganismiPropionibacterium acnes (strain KPA171202 / DSM 16379)
Taxonomic identifieri267747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium
ProteomesiUP000000603: Chromosome

Subcellular locationi

Secretedcell wall By similarity

GO - Cellular componenti

  1. cell wall Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Tat-type signalPROSITE-ProRule annotationAdd
BLAST
Chaini33 – 813781Hyaluronate lyasePRO_0000024930Add
BLAST

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0CZ01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polysaccharide lyase 8 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000243554.
KOiK01727.
OMAiENEWASR.
OrthoDBiEOG6GBM67.

Family and domain databases

Gene3Di1.50.10.100. 1 hit.
2.60.220.10. 1 hit.
2.70.98.10. 1 hit.
InterProiIPR008929. Chondroitin_lyas.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR011071. Lyase_8-like_C.
IPR012970. Lyase_8_alpha_N.
IPR004103. Lyase_8_C.
IPR003159. Lyase_8_central_dom.
IPR012329. Lyase_8_N.
IPR006311. TAT_signal.
[Graphical view]
PfamiPF02278. Lyase_8. 1 hit.
PF02884. Lyase_8_C. 1 hit.
PF08124. Lyase_8_N. 1 hit.
[Graphical view]
SUPFAMiSSF48230. SSF48230. 1 hit.
SSF49863. SSF49863. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CZ01-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFGTPSRRTF LTASALSAMA LAASPTVTDA IAAPGPDSWS ALCERWIDII
60 70 80 90 100
TGRRAARTSD PRARAIIAKT DRKVAEILTD LVSGSSRQTV LISADLRKEQ
110 120 130 140 150
SPFITKTARA IESMACAWAT PGSSYHKDPE ILSACIEGLR DFCRLRYNPS
160 170 180 190 200
QDEYGNWWDW EDGASRAVAD VMCILHDVLP PEVMSAAAAG IDHFIPDPWF
210 220 230 240 250
QQPASVKPTA NPVQPVVSTG ANRMDLTRAV MCRSIATGDE KRLRHAVDGL
260 270 280 290 300
PDAWRVTTEG DGFRADGGFI QHSHIPYTGG YGDVLFSGLA MLFPLVSGMR
310 320 330 340 350
FDIVESARKA FHDQVERGFI PVMYNGQILD DVRGRSISRI NESAAMHGIS
360 370 380 390 400
IARAMLMMAD ALPTHRAEQW RGIVHGWMAR NTFDHLSEPS TLVDISLFDA
410 420 430 440 450
AAKARPVPES STPSYFASMD RLVHRTADWL ITVSNCSDRI AWYEYGNGEN
460 470 480 490 500
EWASRTSQGM RYLLLPGDMG QYEDGYWATV DYSAPTGTTV DSTPLKRAVG
510 520 530 540 550
ASWAAKTPTN EWSGGLASGS WSAAASHITS QDSALKARRL WVGLKDAMVE
560 570 580 590 600
LTTDVTTDAS RAITVVEHRK VASSSTKLLV DGNRVSSATS FQNPRWAHLD
610 620 630 640 650
GVGGYVFATD TDLSADVATR KGTWIDVNPS RKVKGADEVI ERAYASLHVT
660 670 680 690 700
HHDRPVAWAL LPTASRSHTM ALATRPGVEP FTVLRNDATV QAVRSAGALL
710 720 730 740 750
TKDPTVVTTL AFWKPATCGG VAVNRPALVQ TRESANQMEV VIVEPTQKRG
760 770 780 790 800
SLTVTIEGSW KVKTADSHVD VSCENAAGTL HVDTAGLGGQ SVRVTLARQV
810
TQTPSGGGRH DRA
Length:813
Mass (Da):88,130
Last modified:June 28, 2011 - v1
Checksum:i0C4316E7890D4D1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA. Translation: AAT82132.1.
RefSeqiYP_055090.1. NC_006085.1.

Genome annotation databases

EnsemblBacteriaiAAT82132; AAT82132; PPA0380.
GeneIDi2932015.
KEGGipac:PPA0380.
PATRICi23035411. VBIProAcn64440_0390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA. Translation: AAT82132.1 .
RefSeqi YP_055090.1. NC_006085.1.

3D structure databases

ProteinModelPortali P0CZ01.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT82132 ; AAT82132 ; PPA0380 .
GeneIDi 2932015.
KEGGi pac:PPA0380.
PATRICi 23035411. VBIProAcn64440_0390.

Phylogenomic databases

HOGENOMi HOG000243554.
KOi K01727.
OMAi ENEWASR.
OrthoDBi EOG6GBM67.

Enzyme and pathway databases

BioCyci PACN267747:GHO9-377-MONOMER.
BRENDAi 4.2.2.1. 5029.

Family and domain databases

Gene3Di 1.50.10.100. 1 hit.
2.60.220.10. 1 hit.
2.70.98.10. 1 hit.
InterProi IPR008929. Chondroitin_lyas.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR011071. Lyase_8-like_C.
IPR012970. Lyase_8_alpha_N.
IPR004103. Lyase_8_C.
IPR003159. Lyase_8_central_dom.
IPR012329. Lyase_8_N.
IPR006311. TAT_signal.
[Graphical view ]
Pfami PF02278. Lyase_8. 1 hit.
PF02884. Lyase_8_C. 1 hit.
PF08124. Lyase_8_N. 1 hit.
[Graphical view ]
SUPFAMi SSF48230. SSF48230. 1 hit.
SSF49863. SSF49863. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEi PS51318. TAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Propionibacterium acnes, a commensal of human skin."
    Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A., Strittmatter A., Hujer S., Duerre P., Gottschalk G.
    Science 305:671-673(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KPA171202 / DSM 16379.

Entry informationi

Entry nameiHYSA_PROAC
AccessioniPrimary (citable) accession number: P0CZ01
Secondary accession number(s): Q59634, Q6AAT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3