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P0CZ00

- HYSA_PROAA

UniProt

P0CZ00 - HYSA_PROAA

Protein

Hyaluronate lyase

Gene
N/A
Organism
Propionibacterium acnes
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 12 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Cleaves hyaluronate chains at a beta-D-GalNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine.

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. hyaluronate lyase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Enzyme and pathway databases

    BRENDAi4.2.2.1. 5029.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronate lyase (EC:4.2.2.1)
    Alternative name(s):
    Hyaluronidase
    Short name:
    HYase
    OrganismiPropionibacterium acnes
    Taxonomic identifieri1747 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium

    Subcellular locationi

    GO - Cellular componenti

    1. cell wall Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell wall, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Tat-type signalAdd
    BLAST
    Chaini33 – 812780Hyaluronate lyasePRO_0000410486Add
    BLAST

    Post-translational modificationi

    Predicted to be exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven.

    Interactioni

    Subunit structurei

    Monomer.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polysaccharide lyase 8 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di1.50.10.100. 1 hit.
    2.60.220.10. 1 hit.
    2.70.98.10. 1 hit.
    InterProiIPR008929. Chondroitin_lyas.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR011071. Lyase_8-like_C.
    IPR012970. Lyase_8_alpha_N.
    IPR004103. Lyase_8_C.
    IPR003159. Lyase_8_central_dom.
    IPR012329. Lyase_8_N.
    IPR006311. TAT_signal.
    [Graphical view]
    PfamiPF02278. Lyase_8. 1 hit.
    PF02884. Lyase_8_C. 1 hit.
    PF08124. Lyase_8_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF48230. SSF48230. 1 hit.
    SSF49863. SSF49863. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEiPS51318. TAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0CZ00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFGTPSRRTF LTASALSAMA LAASPTVTDA IAAPGPDSWS ALCERWIDII    50
    TGRRAARTSD PRARAIIAKT DRKVAEILTD LVSGSSRQTV LISADLRKEQ 100
    SPFITKTARA IESMACGWAT PGSSYHKDPE ILSACIEGLR DFCRLRYNPS 150
    QDEYGNWWDW EDGASRAVAD VMCILHDVLP PEVMSAAAAG IDHFIPDPWF 200
    QQPGSVKPTA NPVQPVVSTG ANRMDLTRAV MCRSIATGDE KRLRHAVDGL 250
    PDAWRVTTEG DGFRADGGFI QHSHIPYTGG YGDVLFSGLA MLFPLVSGMR 300
    FDIDESARKA FHDQVERGFI PVMYNGQILD DVRGRSISRI NESAAMHGIS 350
    IARAMLMMAD ALPTHRAEQW RGIVHGWMAR NTFDHLSEPS TLVDISLFDA 400
    AAKAPRPGVV DAELLRVHGP SRPATADWLI TVSNCSDRIA WYEYGNGENE 450
    WAYRTSQGMR YLLLPGDMGQ YEDGYWATVD YSAPTGTTVD STPLKRAVGA 500
    SWAAKTPTNE WSGGLASGSW SAAASHITSQ DSALKARRLW VGLKDAMVEL 550
    TTDVTTDASR AITVVEHRKV ASSSTKLLVD GNRVSSATSF QNPRWAHLDG 600
    VGGYVFATDT DLSADVATRK GTWIDVNPSR KVKGADEVIE RAYASLHGHP 650
    PRSSSPWALL PTASRSHTMA LATRPGVEPF TVLRNDGNRP GRASAGALLT 700
    KDPTVVTTLA FWKPATCGGV AVNRPALVQT RESANQMEVV IVEPTQKRGS 750
    LTVTIEGSWK VKTADSHVDV SCENAAGTLH VDTAGLGGQS VRVTLARQVT 800
    QTPSGGGRHD RA 812
    Length:812
    Mass (Da):87,758
    Last modified:June 28, 2011 - v1
    Checksum:iD72FB62E1439CB96
    GO

    Sequence cautioni

    The sequence AAA51650.1 differs from that shown. Reason: Frameshift at positions 717 and 778.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15927 Genomic DNA. Translation: AAA51650.1. Frameshift.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15927 Genomic DNA. Translation: AAA51650.1 . Frameshift.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 4.2.2.1. 5029.

    Family and domain databases

    Gene3Di 1.50.10.100. 1 hit.
    2.60.220.10. 1 hit.
    2.70.98.10. 1 hit.
    InterProi IPR008929. Chondroitin_lyas.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR011071. Lyase_8-like_C.
    IPR012970. Lyase_8_alpha_N.
    IPR004103. Lyase_8_C.
    IPR003159. Lyase_8_central_dom.
    IPR012329. Lyase_8_N.
    IPR006311. TAT_signal.
    [Graphical view ]
    Pfami PF02278. Lyase_8. 1 hit.
    PF02884. Lyase_8_C. 1 hit.
    PF08124. Lyase_8_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48230. SSF48230. 1 hit.
    SSF49863. SSF49863. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEi PS51318. TAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of the hyaluronate lyase gene from Propionibacterium acnes."
      Steiner B.M., Romero-Steiner S., Cruce D., George R.
      Can. J. Microbiol. 43:315-321(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
      Strain: 49/51.

    Entry informationi

    Entry nameiHYSA_PROAA
    AccessioniPrimary (citable) accession number: P0CZ00
    Secondary accession number(s): Q59634, Q6AAT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 12 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3