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P0CZ00

- HYSA_PROAA

UniProt

P0CZ00 - HYSA_PROAA

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Protein

Hyaluronate lyase

Gene
N/A
Organism
Propionibacterium acnes
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Cleaves hyaluronate chains at a beta-D-GalNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine.

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. hyaluronate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BRENDAi4.2.2.1. 5029.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronate lyase (EC:4.2.2.1)
Alternative name(s):
Hyaluronidase
Short name:
HYase
OrganismiPropionibacterium acnes
Taxonomic identifieri1747 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesPropionibacterineaePropionibacteriaceaePropionibacterium

Subcellular locationi

GO - Cellular componenti

  1. cell wall Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Tat-type signalAdd
BLAST
Chaini33 – 812780Hyaluronate lyasePRO_0000410486Add
BLAST

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven.

Interactioni

Subunit structurei

Monomer.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.50.10.100. 1 hit.
2.60.220.10. 1 hit.
2.70.98.10. 1 hit.
InterProiIPR008929. Chondroitin_lyas.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR011071. Lyase_8-like_C.
IPR012970. Lyase_8_alpha_N.
IPR004103. Lyase_8_C.
IPR003159. Lyase_8_central_dom.
IPR012329. Lyase_8_N.
IPR006311. TAT_signal.
[Graphical view]
PfamiPF02278. Lyase_8. 1 hit.
PF02884. Lyase_8_C. 1 hit.
PF08124. Lyase_8_N. 1 hit.
[Graphical view]
SUPFAMiSSF48230. SSF48230. 1 hit.
SSF49863. SSF49863. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CZ00-1 [UniParc]FASTAAdd to Basket

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MFGTPSRRTF LTASALSAMA LAASPTVTDA IAAPGPDSWS ALCERWIDII    50
TGRRAARTSD PRARAIIAKT DRKVAEILTD LVSGSSRQTV LISADLRKEQ 100
SPFITKTARA IESMACGWAT PGSSYHKDPE ILSACIEGLR DFCRLRYNPS 150
QDEYGNWWDW EDGASRAVAD VMCILHDVLP PEVMSAAAAG IDHFIPDPWF 200
QQPGSVKPTA NPVQPVVSTG ANRMDLTRAV MCRSIATGDE KRLRHAVDGL 250
PDAWRVTTEG DGFRADGGFI QHSHIPYTGG YGDVLFSGLA MLFPLVSGMR 300
FDIDESARKA FHDQVERGFI PVMYNGQILD DVRGRSISRI NESAAMHGIS 350
IARAMLMMAD ALPTHRAEQW RGIVHGWMAR NTFDHLSEPS TLVDISLFDA 400
AAKAPRPGVV DAELLRVHGP SRPATADWLI TVSNCSDRIA WYEYGNGENE 450
WAYRTSQGMR YLLLPGDMGQ YEDGYWATVD YSAPTGTTVD STPLKRAVGA 500
SWAAKTPTNE WSGGLASGSW SAAASHITSQ DSALKARRLW VGLKDAMVEL 550
TTDVTTDASR AITVVEHRKV ASSSTKLLVD GNRVSSATSF QNPRWAHLDG 600
VGGYVFATDT DLSADVATRK GTWIDVNPSR KVKGADEVIE RAYASLHGHP 650
PRSSSPWALL PTASRSHTMA LATRPGVEPF TVLRNDGNRP GRASAGALLT 700
KDPTVVTTLA FWKPATCGGV AVNRPALVQT RESANQMEVV IVEPTQKRGS 750
LTVTIEGSWK VKTADSHVDV SCENAAGTLH VDTAGLGGQS VRVTLARQVT 800
QTPSGGGRHD RA 812
Length:812
Mass (Da):87,758
Last modified:June 28, 2011 - v1
Checksum:iD72FB62E1439CB96
GO

Sequence cautioni

The sequence AAA51650.1 differs from that shown. Reason: Frameshift at positions 717 and 778.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15927 Genomic DNA. Translation: AAA51650.1. Frameshift.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15927 Genomic DNA. Translation: AAA51650.1 . Frameshift.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 4.2.2.1. 5029.

Family and domain databases

Gene3Di 1.50.10.100. 1 hit.
2.60.220.10. 1 hit.
2.70.98.10. 1 hit.
InterProi IPR008929. Chondroitin_lyas.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR011071. Lyase_8-like_C.
IPR012970. Lyase_8_alpha_N.
IPR004103. Lyase_8_C.
IPR003159. Lyase_8_central_dom.
IPR012329. Lyase_8_N.
IPR006311. TAT_signal.
[Graphical view ]
Pfami PF02278. Lyase_8. 1 hit.
PF02884. Lyase_8_C. 1 hit.
PF08124. Lyase_8_N. 1 hit.
[Graphical view ]
SUPFAMi SSF48230. SSF48230. 1 hit.
SSF49863. SSF49863. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEi PS51318. TAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of the hyaluronate lyase gene from Propionibacterium acnes."
    Steiner B.M., Romero-Steiner S., Cruce D., George R.
    Can. J. Microbiol. 43:315-321(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: 49/51.

Entry informationi

Entry nameiHYSA_PROAA
AccessioniPrimary (citable) accession number: P0CZ00
Secondary accession number(s): Q59634, Q6AAT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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