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Protein

Conotoxin Bu1.4

Gene
N/A
Organism
Conus bullatus (Bubble cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Bu1.4
Alternative name(s):
Bu1.3
Conotoxin Bu20
OrganismiConus bullatus (Bubble cone)
Taxonomic identifieri89438 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000040999224 – 46By similarityAdd BLAST23
PeptideiPRO_000040999347 – 63Conotoxin Bu1.4Add BLAST17

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63Threonine amideBy similarity1

Post-translational modificationi

Contains 2 disulfide bonds (By similarity). They are not indicated here, since framework I presents two different connectivities (I-III, II-IV and I-IV, II-III).By similarity

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/4 pattern.

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958. Conotoxin_a-typ.
PfamiView protein in Pfam
PF07365. Toxin_8. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CY88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMRMRMMFT VFLLVVLANT VVSFPSDRDS DGADAEASDE PVEFERDENG
60
CCWNPSCPRP RCTGRR
Length:66
Mass (Da):7,460
Last modified:June 28, 2011 - v1
Checksum:iE3F5D8B3280C0C02
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19N → T in AR584845 (Ref. 2) Curated1
Sequence conflicti19N → T in CAR81558 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AR584845 Genomic DNA. No translation available.
FB299974 Unassigned DNA. Translation: CAR81558.1.

Similar proteinsi

Entry informationi

Entry nameiCA120_CONBU
AccessioniPrimary (citable) accession number: P0CY88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 22, 2017
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Caution

There is a discrepancy in nomenclature: was submitted as Bu1.4 in PubMed:20143226 but is named Bu1.3 in ConoServer.Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families