P0CY49 (CY1_RHOCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c1

Gene names

Name:

petC

Organism

Rhodobacter capsulatus (Rhodopseudomonas capsulata)

Taxonomic identifier

1061 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. c1 functions as an electron donor to cytochrome c.
Subunit structure	The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.
Subcellular location	Cell membrane; Single-pass membrane protein Potential.
Post-translational modification	Binds 1 heme group per subunit.
Caution	The sequence reported in Ref.1 was thought to originate from R.sphaeroides but was later shown (Ref.2) to be derived from R.capsulatus.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Technical term	3D-structure
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

21

Chain

22 – 280

259

Cytochrome c1

PRO_0000006561

Regions

Transmembrane

249 – 267

19

Helical; Note=Anchors to the membrane; Potential

Sites

Metal binding

59

1

Iron (heme axial ligand)

Metal binding

205

1

Iron (heme axial ligand) By similarity

Binding site

55

1

Heme (covalent)

Binding site

58

1

Heme (covalent)

Secondary structure

1

.

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.

.

.

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280

Helix Strand Turn

Details...

Beta strand

31 – 36

6

Helix

41 – 53

13

Turn

54 – 58

5

Helix

66 – 68

3

Beta strand

69 – 74

6

Helix

79 – 88

10

Beta strand

95 – 97

3

Beta strand

114 – 116

3

Turn

122 – 124

3

Helix

125 – 127

3

Helix

149 – 156

8

Beta strand

194 – 196

3

Helix

224 – 239

16

Helix

243 – 272

30

Sequences

	Sequence		Length	Mass (Da)
	P0CY49 [UniParc]. Last modified June 28, 2011. Version 1. Checksum: A2A54A357DC976E5	FASTA	280	30,383
	10 20 30 40 50 60 MKKLLISAVS ALVLGSGAAL ANSNVQDHAF SFEGIFGKFD QAQLRRGFQV YSEVCSTCHG 70 80 90 100 110 120 MKFVPIRTLS DDGGPQLDPT FVREYAAGLD TIIDKDSGEE RDRKETDMFP TRVGDGMGPD 130 140 150 160 170 180 LSVMAKARAG FSGPAGSGMN QLFKGIGGPE YIYRYVTGFP EENPACAPEG IDGYYYNEVF 190 200 210 220 230 240 QVGGVPDTCK DAAGIKTTHG SWAQMPPALF DDLVTYEDGT PATVDQMGQD VASFLMWAAE 250 260 270 280 PKLVARKQMG LVAVVMLGLL SVMLYLTNKR LWAPYKRQKA

References

[1]	"Nucleotide sequence and transcription of the fbc operon from Rhodopseudomonas sphaeroides. Evaluation of the deduced amino acid sequences of the FeS protein, cytochrome b and cytochrome c1." Gabellini N., Sebald W. Eur. J. Biochem. 154:569-579(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: GA.
[2]	"fbc operon, encoding the Rieske Fe-S protein cytochrome b, and cytochrome c1 apoproteins previously described from Rhodopseudomonas sphaeroides, is from Rhodopseudomonas capsulata." Davidson E., Daldal F. J. Mol. Biol. 195:25-29(1987) [PubMed] [Europe PMC] [Abstract] Cited for: SHOWS THAT SEQUENCE DESCRIBED IN PUBMED:3004982 ORIGINATES FROM RHODOBACTER CAPSULATUS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X03476 Genomic DNA. Translation: CAA27196.1.

PIR

C25405.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ZRT	X-ray	3.50	D/Q	22-279	[»]

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOGENOM

HOG000003867.

Family and domain databases

InterPro

IPR002326. Cyt_c1.
IPR009056. Cyt_c_dom.
[Graphical view]

PANTHER

PTHR10266. PTHR10266. 1 hit.

Pfam

PF02167. Cytochrom_C1. 1 hit.
[Graphical view]

PRINTS

PR00603. CYTOCHROMEC1.

SUPFAM

SSF46626. Cytochrome_c. 1 hit.

PROSITE

PS51007. CYTC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P0CY49.

Entry information

Entry name

CY1_RHOCA

Accession

Primary (citable) accession number: P0CY49
Secondary accession number(s): P07058, P08501

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 28, 2011
Last sequence update:	June 28, 2011
Last modified:	April 3, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program