P0CY33 (CDC42_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell division control protein 42 homolog

Gene names

Name:	CDC42
ORF Names:	CaO19.390, CaO19.8020

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in hyphal formation, virulence, morphogenesis.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Virulence
Cellular component	Cell membrane Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Rho protein signal transduction Inferred from sequence or structural similarity PubMed 9229333. Source: CGD cell budding Inferred from mutant phenotype PubMed 12366849PubMed 12455975. Source: CGD cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell growth mode switching, budding to filamentous Inferred from mutant phenotype PubMed 12455975PubMed 12582118. Source: CGD cell morphogenesis Inferred from mutant phenotype PubMed 12455975PubMed 12582118. Source: CGD cellular response to biotic stimulus Inferred from mutant phenotype PubMed 12366849PubMed 12582118PubMed 15755921. Source: CGD cytokinetic cell separation Inferred from mutant phenotype PubMed 12366849. Source: CGD establishment of cell polarity Inferred from mutant phenotype PubMed 12582118. Source: CGD filamentous growth of a population of unicellular organisms in response to biotic stimulus Inferred from mutant phenotype PubMed 12366849PubMed 12455975PubMed 12582118PubMed 15755921PubMed 16467473. Source: CGD hyphal growth Inferred from mutant phenotype PubMed 15189993. Source: CGD pathogenesis Inferred from mutant phenotype PubMed 12582118. Source: CGD positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus Inferred from mutant phenotype PubMed 12366849PubMed 12582118PubMed 15755921. Source: CGD regulation of cell growth Inferred from mutant phenotype PubMed 12455975. Source: CGD
Cellular_component	cell septum Non-traceable author statement PubMed 15755921. Source: CGD cellular bud neck Inferred from direct assay PubMed 12477786. Source: CGD cellular bud tip Inferred from direct assay PubMed 12477786PubMed 16467473. Source: CGD hyphal tip polarisome Inferred from direct assay PubMed 15976451. Source: CGD membrane Inferred from mutant phenotype PubMed 12455975. Source: CGD plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell spitzenkorper Inferred from direct assay PubMed 15976451. Source: CGD
Molecular_function	GTP binding Inferred from direct assay PubMed 16467473. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Cell division control protein 42 homolog		PRO_0000198952
	Propeptide	189 – 191	3	Removed in mature form By similarity		PRO_0000281282
Regions
	Nucleotide binding	10 – 17	8	GTP By similarity
	Nucleotide binding	57 – 61	5	GTP By similarity
	Nucleotide binding	115 – 118	4	GTP By similarity
	Motif	32 – 40	9	Effector region By similarity
Amino acid modifications
	Modified residue	188	1	Cysteine methyl ester By similarity
	Lipidation	188	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0CY33 [UniParc]. Last modified October 19, 2011. Version 1. Checksum: 6F92C17659AD0AD9	FASTA	191	21,263
	10 20 30 40 50 60 MQTIKCVVVG DGAVGKTCLL ISYTTSKFPA DYVPTVFDNY AVTVMIGDEP FTLGLFDTAG 70 80 90 100 110 120 QEDYDRLRPL SYPSTDVFLV CFSVISPASF ENVKEKWFPE VHHHCPGVPI IIVGTQTDLR 130 140 150 160 170 180 NDDVILQRLH RQKLSPITQE QGEKLAKELR AVKYVECSAL TQRGLKTVFD EAIVAALEPP 190 VIKKSKKCTI L

References

[1]

"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000177 Genomic DNA. Translation: EAK92670.1. AACQ01000176 Genomic DNA. Translation: EAK92699.1.
RefSeq	XP_711878.1. XM_706785.1. XP_711907.1. XM_706814.1.
3D structure databases
ProteinModelPortal	P0CY33.
SMR	P0CY33. Positions 1-191.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3646479. 3646488.
KEGG	cal:CaO19.390. cal:CaO19.8020.
Organism-specific databases
CGD	CAL0004942. CDC42.
Phylogenomic databases
KO	K04393.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003578. Small_GTPase_Rho. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00174. RHO. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51420. RHO. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDC42_CANAL

Accession

Primary (citable) accession number: P0CY33
Secondary accession number(s): O14426, Q59QC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2011
Last sequence update:	October 19, 2011
Last modified:	March 6, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program