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P0CY33

- CDC42_CANAL

UniProt

P0CY33 - CDC42_CANAL

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Protein
Cell division control protein 42 homolog
Gene
CDC42, CaO19.390, CaO19.8020
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Involved in hyphal formation, virulence, morphogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178GTP By similarity
Nucleotide bindingi57 – 615GTP By similarity
Nucleotide bindingi115 – 1184GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: CGD
Complete GO annotation...

GO - Biological processi

  1. Rho protein signal transduction Source: CGD
  2. cell budding Source: CGD
  3. cell growth mode switching, budding to filamentous Source: CGD
  4. cell morphogenesis Source: CGD
  5. cytokinetic cell separation Source: CGD
  6. establishment of cell polarity Source: CGD
  7. filamentous growth Source: CGD
  8. filamentous growth of a population of unicellular organisms Source: CGD
  9. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  10. fungal-type cell wall organization Source: CGD
  11. hyphal growth Source: CGD
  12. pathogenesis Source: CGD
  13. positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  14. regulation of cell growth Source: CGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Virulence

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 42 homolog
Gene namesi
Name:CDC42
ORF Names:CaO19.390, CaO19.8020
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0004942. CDC42.

Subcellular locationi

GO - Cellular componenti

  1. cell septum Source: CGD
  2. cellular bud neck Source: CGD
  3. cellular bud tip Source: CGD
  4. hyphal tip Source: CGD
  5. hyphal tip polarisome Source: CGD
  6. membrane Source: CGD
  7. nucleus Source: CGD
  8. plasma membrane Source: CGD
  9. spitzenkorper Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Cell division control protein 42 homolog
PRO_0000198952Add
BLAST
Propeptidei189 – 1913Removed in mature form By similarity
PRO_0000281282

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei188 – 1881Cysteine methyl ester By similarity
Lipidationi188 – 1881S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Protein-protein interaction databases

IntActiP0CY33. 2 interactions.
MINTiMINT-5223869.

Structurei

3D structure databases

ProteinModelPortaliP0CY33.
SMRiP0CY33. Positions 1-191.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 409Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

KOiK04393.
OrthoDBiEOG7SN8QP.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CY33-1 [UniParc]FASTAAdd to Basket

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MQTIKCVVVG DGAVGKTCLL ISYTTSKFPA DYVPTVFDNY AVTVMIGDEP    50
FTLGLFDTAG QEDYDRLRPL SYPSTDVFLV CFSVISPASF ENVKEKWFPE 100
VHHHCPGVPI IIVGTQTDLR NDDVILQRLH RQKLSPITQE QGEKLAKELR 150
AVKYVECSAL TQRGLKTVFD EAIVAALEPP VIKKSKKCTI L 191
Length:191
Mass (Da):21,263
Last modified:October 19, 2011 - v1
Checksum:i6F92C17659AD0AD9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000177 Genomic DNA. Translation: EAK92670.1.
AACQ01000176 Genomic DNA. Translation: EAK92699.1.
RefSeqiXP_711878.1. XM_706785.1.
XP_711907.1. XM_706814.1.

Genome annotation databases

GeneIDi3646479.
3646488.
KEGGical:CaO19.390.
cal:CaO19.8020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000177 Genomic DNA. Translation: EAK92670.1 .
AACQ01000176 Genomic DNA. Translation: EAK92699.1 .
RefSeqi XP_711878.1. XM_706785.1.
XP_711907.1. XM_706814.1.

3D structure databases

ProteinModelPortali P0CY33.
SMRi P0CY33. Positions 1-191.
ModBasei Search...

Protein-protein interaction databases

IntActi P0CY33. 2 interactions.
MINTi MINT-5223869.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3646479.
3646488.
KEGGi cal:CaO19.390.
cal:CaO19.8020.

Organism-specific databases

CGDi CAL0004942. CDC42.

Phylogenomic databases

KOi K04393.
OrthoDBi EOG7SN8QP.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00174. RHO. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51420. RHO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiCDC42_CANAL
AccessioniPrimary (citable) accession number: P0CY33
Secondary accession number(s): O14426, Q59QC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 16, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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