Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0CY33

- CDC42_CANAL

UniProt

P0CY33 - CDC42_CANAL

Protein

Cell division control protein 42 homolog

Gene

CDC42

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in hyphal formation, virulence, morphogenesis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 178GTPBy similarity
    Nucleotide bindingi57 – 615GTPBy similarity
    Nucleotide bindingi115 – 1184GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: CGD

    GO - Biological processi

    1. cell budding Source: CGD
    2. cell growth mode switching, budding to filamentous Source: CGD
    3. cell morphogenesis Source: CGD
    4. cytokinetic cell separation Source: CGD
    5. establishment of cell polarity Source: CGD
    6. filamentous growth Source: CGD
    7. filamentous growth of a population of unicellular organisms Source: CGD
    8. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
    9. fungal-type cell wall organization Source: CGD
    10. hyphal growth Source: CGD
    11. pathogenesis Source: CGD
    12. positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
    13. regulation of cell growth Source: CGD
    14. Rho protein signal transduction Source: CGD

    Keywords - Biological processi

    Cell cycle, Cell division, Virulence

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division control protein 42 homolog
    Gene namesi
    Name:CDC42
    ORF Names:CaO19.390, CaO19.8020
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0004942. CDC42.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. cell septum Source: CGD
    2. cellular bud neck Source: CGD
    3. cellular bud tip Source: CGD
    4. hyphal tip Source: CGD
    5. hyphal tip polarisome Source: CGD
    6. membrane Source: CGD
    7. nucleus Source: CGD
    8. plasma membrane Source: CGD
    9. spitzenkorper Source: CGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 188188Cell division control protein 42 homologPRO_0000198952Add
    BLAST
    Propeptidei189 – 1913Removed in mature formBy similarityPRO_0000281282

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei188 – 1881Cysteine methyl esterBy similarity
    Lipidationi188 – 1881S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Interactioni

    Protein-protein interaction databases

    IntActiP0CY33. 2 interactions.
    MINTiMINT-5223869.

    Structurei

    3D structure databases

    ProteinModelPortaliP0CY33.
    SMRiP0CY33. Positions 1-191.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi32 – 409Effector regionBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    KOiK04393.
    OrthoDBiEOG7SN8QP.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00174. RHO. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51420. RHO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0CY33-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQTIKCVVVG DGAVGKTCLL ISYTTSKFPA DYVPTVFDNY AVTVMIGDEP    50
    FTLGLFDTAG QEDYDRLRPL SYPSTDVFLV CFSVISPASF ENVKEKWFPE 100
    VHHHCPGVPI IIVGTQTDLR NDDVILQRLH RQKLSPITQE QGEKLAKELR 150
    AVKYVECSAL TQRGLKTVFD EAIVAALEPP VIKKSKKCTI L 191
    Length:191
    Mass (Da):21,263
    Last modified:October 19, 2011 - v1
    Checksum:i6F92C17659AD0AD9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000177 Genomic DNA. Translation: EAK92670.1.
    AACQ01000176 Genomic DNA. Translation: EAK92699.1.
    RefSeqiXP_711878.1. XM_706785.1.
    XP_711907.1. XM_706814.1.

    Genome annotation databases

    GeneIDi3646479.
    3646488.
    KEGGical:CaO19.390.
    cal:CaO19.8020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000177 Genomic DNA. Translation: EAK92670.1 .
    AACQ01000176 Genomic DNA. Translation: EAK92699.1 .
    RefSeqi XP_711878.1. XM_706785.1.
    XP_711907.1. XM_706814.1.

    3D structure databases

    ProteinModelPortali P0CY33.
    SMRi P0CY33. Positions 1-191.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P0CY33. 2 interactions.
    MINTi MINT-5223869.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3646479.
    3646488.
    KEGGi cal:CaO19.390.
    cal:CaO19.8020.

    Organism-specific databases

    CGDi CAL0004942. CDC42.

    Phylogenomic databases

    KOi K04393.
    OrthoDBi EOG7SN8QP.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00174. RHO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51420. RHO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiCDC42_CANAL
    AccessioniPrimary (citable) accession number: P0CY33
    Secondary accession number(s): O14426, Q59QC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3