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P0CY33 (CDC42_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division control protein 42 homolog
Gene names
Name:CDC42
ORF Names:CaO19.390, CaO19.8020
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in hyphal formation, virulence, morphogenesis.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Sequence similarities

Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Virulence
   Cellular componentCell membrane
Membrane
   LigandGTP-binding
Nucleotide-binding
   PTMLipoprotein
Methylation
Prenylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRho protein signal transduction

Inferred from sequence or structural similarity PubMed 9229333. Source: CGD

cell budding

Inferred from mutant phenotype PubMed 12366849PubMed 12455975. Source: CGD

cell growth mode switching, budding to filamentous

Inferred from mutant phenotype PubMed 12455975PubMed 12582118. Source: CGD

cell morphogenesis

Inferred from mutant phenotype PubMed 12455975PubMed 12582118. Source: CGD

cytokinetic cell separation

Inferred from mutant phenotype PubMed 12366849. Source: CGD

establishment of cell polarity

Inferred from mutant phenotype PubMed 12582118. Source: CGD

filamentous growth

Inferred from mutant phenotype PubMed 12366849PubMed 12582118PubMed 15755921. Source: CGD

filamentous growth of a population of unicellular organisms

Inferred from mutant phenotype PubMed 16467473. Source: CGD

filamentous growth of a population of unicellular organisms in response to biotic stimulus

Inferred from mutant phenotype PubMed 12366849PubMed 12455975PubMed 12582118PubMed 15755921PubMed 16467473. Source: CGD

fungal-type cell wall organization

Inferred from mutant phenotype PubMed 20444104. Source: CGD

hyphal growth

Inferred from mutant phenotype PubMed 15189993. Source: CGD

pathogenesis

Inferred from mutant phenotype PubMed 12582118. Source: CGD

positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus

Inferred from mutant phenotype PubMed 12366849PubMed 12582118PubMed 15755921. Source: CGD

regulation of cell growth

Inferred from mutant phenotype PubMed 12455975. Source: CGD

   Cellular_componentcell septum

Non-traceable author statement PubMed 15755921. Source: CGD

cellular bud neck

Inferred from direct assay PubMed 12477786. Source: CGD

cellular bud tip

Inferred from direct assay PubMed 12477786PubMed 16467473. Source: CGD

hyphal tip

Inferred from direct assay PubMed 12477786PubMed 16467473PubMed 23796158. Source: CGD

hyphal tip polarisome

Inferred from direct assay PubMed 15976451. Source: CGD

membrane

Inferred from direct assay PubMed 20444104. Source: CGD

nucleus

Inferred from direct assay PubMed 21060846. Source: CGD

plasma membrane

Inferred from direct assay PubMed 16467473. Source: CGD

spitzenkorper

Inferred from direct assay PubMed 15976451. Source: CGD

   Molecular_functionGTP binding

Inferred from direct assay PubMed 16467473. Source: CGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 188188Cell division control protein 42 homolog
PRO_0000198952
Propeptide189 – 1913Removed in mature form By similarity
PRO_0000281282

Regions

Nucleotide binding10 – 178GTP By similarity
Nucleotide binding57 – 615GTP By similarity
Nucleotide binding115 – 1184GTP By similarity
Motif32 – 409Effector region By similarity

Amino acid modifications

Modified residue1881Cysteine methyl ester By similarity
Lipidation1881S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P0CY33 [UniParc].

Last modified October 19, 2011. Version 1.
Checksum: 6F92C17659AD0AD9

FASTA19121,263
        10         20         30         40         50         60 
MQTIKCVVVG DGAVGKTCLL ISYTTSKFPA DYVPTVFDNY AVTVMIGDEP FTLGLFDTAG 

        70         80         90        100        110        120 
QEDYDRLRPL SYPSTDVFLV CFSVISPASF ENVKEKWFPE VHHHCPGVPI IIVGTQTDLR 

       130        140        150        160        170        180 
NDDVILQRLH RQKLSPITQE QGEKLAKELR AVKYVECSAL TQRGLKTVFD EAIVAALEPP 

       190 
VIKKSKKCTI L 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000177 Genomic DNA. Translation: EAK92670.1.
AACQ01000176 Genomic DNA. Translation: EAK92699.1.
RefSeqXP_711878.1. XM_706785.1.
XP_711907.1. XM_706814.1.

3D structure databases

ProteinModelPortalP0CY33.
SMRP0CY33. Positions 1-191.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP0CY33. 2 interactions.
MINTMINT-5223869.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3646479.
3646488.
KEGGcal:CaO19.390.
cal:CaO19.8020.

Organism-specific databases

CGDCAL0004942. CDC42.

Phylogenomic databases

KOK04393.
OrthoDBEOG7SN8QP.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDC42_CANAL
AccessionPrimary (citable) accession number: P0CY33
Secondary accession number(s): O14426, Q59QC8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: April 16, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names