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Protein

Cell division control protein 42 homolog

Gene

CDC42

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Involved in hyphal formation, virulence, morphogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi115 – 118GTPBy similarity4

GO - Molecular functioni

  • GTP binding Source: CGD

GO - Biological processi

  • cell budding Source: CGD
  • cell cycle Source: UniProtKB-KW
  • cell growth mode switching, budding to filamentous Source: CGD
  • cell morphogenesis Source: CGD
  • cell separation after cytokinesis Source: CGD
  • establishment of cell polarity Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • hyphal growth Source: CGD
  • pathogenesis Source: CGD
  • positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • regulation of cell growth Source: CGD
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Virulence

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 42 homolog
Gene namesi
Name:CDC42
ORF Names:CaO19.390, CaO19.8020
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000192612. CDC42.

Subcellular locationi

GO - Cellular componenti

  • cell septum Source: CGD
  • cellular bud neck Source: CGD
  • cellular bud tip Source: CGD
  • hyphal tip Source: CGD
  • hyphal tip polarisome Source: CGD
  • membrane Source: CGD
  • plasma membrane Source: UniProtKB-SubCell
  • spitzenkorper Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001989521 – 188Cell division control protein 42 homologAdd BLAST188
PropeptideiPRO_0000281282189 – 191Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188Cysteine methyl esterBy similarity1
Lipidationi188S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiP0CY33.

Interactioni

Protein-protein interaction databases

IntActiP0CY33. 2 interactors.
MINTiMINT-5223869.

Structurei

3D structure databases

ProteinModelPortaliP0CY33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionBy similarity9

Sequence similaritiesi

Phylogenomic databases

InParanoidiP0CY33.
KOiK04393.
OrthoDBiEOG092C4TDG.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CY33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTIKCVVVG DGAVGKTCLL ISYTTSKFPA DYVPTVFDNY AVTVMIGDEP
60 70 80 90 100
FTLGLFDTAG QEDYDRLRPL SYPSTDVFLV CFSVISPASF ENVKEKWFPE
110 120 130 140 150
VHHHCPGVPI IIVGTQTDLR NDDVILQRLH RQKLSPITQE QGEKLAKELR
160 170 180 190
AVKYVECSAL TQRGLKTVFD EAIVAALEPP VIKKSKKCTI L
Length:191
Mass (Da):21,263
Last modified:October 19, 2011 - v1
Checksum:i6F92C17659AD0AD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000177 Genomic DNA. Translation: EAK92670.1.
AACQ01000176 Genomic DNA. Translation: EAK92699.1.
RefSeqiXP_711878.1. XM_706785.1.
XP_711907.1. XM_706814.1.

Genome annotation databases

EnsemblFungiiEAK92670; EAK92670; CaO19.390.
EAK92699; EAK92699; CaO19.8020.
GeneIDi3646479.
3646488.
KEGGical:CaO19.390.
cal:CaO19.8020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000177 Genomic DNA. Translation: EAK92670.1.
AACQ01000176 Genomic DNA. Translation: EAK92699.1.
RefSeqiXP_711878.1. XM_706785.1.
XP_711907.1. XM_706814.1.

3D structure databases

ProteinModelPortaliP0CY33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0CY33. 2 interactors.
MINTiMINT-5223869.

Proteomic databases

PRIDEiP0CY33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK92670; EAK92670; CaO19.390.
EAK92699; EAK92699; CaO19.8020.
GeneIDi3646479.
3646488.
KEGGical:CaO19.390.
cal:CaO19.8020.

Organism-specific databases

CGDiCAL0000192612. CDC42.

Phylogenomic databases

InParanoidiP0CY33.
KOiK04393.
OrthoDBiEOG092C4TDG.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDC42_CANAL
AccessioniPrimary (citable) accession number: P0CY33
Secondary accession number(s): O14426, Q59QC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: October 5, 2016
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.