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P0CY19

- DUT_CANAL

UniProt

P0CY19 - DUT_CANAL

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Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
DUT1, CaO19.10832, CaO19.3322
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031Substrate; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei148 – 1481Substrate By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: CGD
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA replication Source: CGD
  2. dUMP biosynthetic process Source: UniProtKB-UniPathway
  3. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.6.1.23. 1124.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:DUT1
ORF Names:CaO19.10832, CaO19.3322
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0004091. DUT1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182930Add
BLAST

Interactioni

Subunit structurei

Homotrimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP0CY19.
SMRiP0CY19. Positions 25-159.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni78 – 803Substrate binding By similarity
Regioni92 – 954Substrate binding By similarity
Regioni153 – 1542Substrate binding By similarity

Sequence similaritiesi

Belongs to the dUTPase family.

Phylogenomic databases

KOiK01520.
OrthoDBiEOG7T7H6C.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CY19-1 [UniParc]FASTAAdd to Basket

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MTSEDQSLKK QKLESTQSLK VYLRSPKGKV PTKGSALAAG YDLYSAEAAT    50
IPAHGQGLVS TDISIIVPIG TYGRVAPRSG LAVKHGISTG AGVIDADYRG 100
EVKVVLFNHS EKDFEIKEGD RIAQLVLEQI VNADIKEISL EELDNTERGE 150
GGFGSTGKN 159
Length:159
Mass (Da):16,945
Last modified:October 19, 2011 - v1
Checksum:i982C016F1D31013A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000045 Genomic DNA. Translation: EAK99213.1.
AACQ01000042 Genomic DNA. Translation: EAK99488.1.
PIRiS51498.
RefSeqiXP_718145.1. XM_713052.1.
XP_718414.1. XM_713321.1.

Genome annotation databases

GeneIDi3639915.
3640188.
KEGGical:CaO19.10832.
cal:CaO19.3322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000045 Genomic DNA. Translation: EAK99213.1 .
AACQ01000042 Genomic DNA. Translation: EAK99488.1 .
PIRi S51498.
RefSeqi XP_718145.1. XM_713052.1.
XP_718414.1. XM_713321.1.

3D structure databases

ProteinModelPortali P0CY19.
SMRi P0CY19. Positions 25-159.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3639915.
3640188.
KEGGi cal:CaO19.10832.
cal:CaO19.3322.

Organism-specific databases

CGDi CAL0004091. DUT1.

Phylogenomic databases

KOi K01520.
OrthoDBi EOG7T7H6C.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .
BRENDAi 3.6.1.23. 1124.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiDUT_CANAL
AccessioniPrimary (citable) accession number: P0CY19
Secondary accession number(s): P43058, Q5A912
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: June 11, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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