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P0CY19

- DUT_CANAL

UniProt

P0CY19 - DUT_CANAL

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.By similarity

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei103 – 1031Substrate; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei148 – 1481SubstrateBy similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: CGD
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. DNA replication Source: CGD
    2. dUMP biosynthetic process Source: UniProtKB-UniPathway
    3. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BRENDAi3.6.1.23. 1124.
    UniPathwayiUPA00610; UER00666.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Name:DUT1
    ORF Names:CaO19.10832, CaO19.3322
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0004091. DUT1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 159159Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182930Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP0CY19.
    SMRiP0CY19. Positions 25-159.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni78 – 803Substrate bindingBy similarity
    Regioni92 – 954Substrate bindingBy similarity
    Regioni153 – 1542Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Phylogenomic databases

    KOiK01520.
    OrthoDBiEOG7T7H6C.

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0CY19-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSEDQSLKK QKLESTQSLK VYLRSPKGKV PTKGSALAAG YDLYSAEAAT    50
    IPAHGQGLVS TDISIIVPIG TYGRVAPRSG LAVKHGISTG AGVIDADYRG 100
    EVKVVLFNHS EKDFEIKEGD RIAQLVLEQI VNADIKEISL EELDNTERGE 150
    GGFGSTGKN 159
    Length:159
    Mass (Da):16,945
    Last modified:October 19, 2011 - v1
    Checksum:i982C016F1D31013A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000045 Genomic DNA. Translation: EAK99213.1.
    AACQ01000042 Genomic DNA. Translation: EAK99488.1.
    PIRiS51498.
    RefSeqiXP_718145.1. XM_713052.1.
    XP_718414.1. XM_713321.1.

    Genome annotation databases

    GeneIDi3639915.
    3640188.
    KEGGical:CaO19.10832.
    cal:CaO19.3322.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000045 Genomic DNA. Translation: EAK99213.1 .
    AACQ01000042 Genomic DNA. Translation: EAK99488.1 .
    PIRi S51498.
    RefSeqi XP_718145.1. XM_713052.1.
    XP_718414.1. XM_713321.1.

    3D structure databases

    ProteinModelPortali P0CY19.
    SMRi P0CY19. Positions 25-159.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3639915.
    3640188.
    KEGGi cal:CaO19.10832.
    cal:CaO19.3322.

    Organism-specific databases

    CGDi CAL0004091. DUT1.

    Phylogenomic databases

    KOi K01520.
    OrthoDBi EOG7T7H6C.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00666 .
    BRENDAi 3.6.1.23. 1124.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiDUT_CANAL
    AccessioniPrimary (citable) accession number: P0CY19
    Secondary accession number(s): P43058, Q5A912
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3