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P0CY19 (DUT_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:DUT1
ORF Names:CaO19.10832, CaO19.3322
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length159 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Subunit structure

Homotrimer By similarity.

Sequence similarities

Belongs to the dUTPase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 159159Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182930

Regions

Region78 – 803Substrate binding By similarity
Region92 – 954Substrate binding By similarity
Region153 – 1542Substrate binding By similarity

Sites

Binding site1031Substrate; via amide nitrogen and carbonyl oxygen By similarity
Binding site1481Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P0CY19 [UniParc].

Last modified October 19, 2011. Version 1.
Checksum: 982C016F1D31013A

FASTA15916,945
        10         20         30         40         50         60 
MTSEDQSLKK QKLESTQSLK VYLRSPKGKV PTKGSALAAG YDLYSAEAAT IPAHGQGLVS 

        70         80         90        100        110        120 
TDISIIVPIG TYGRVAPRSG LAVKHGISTG AGVIDADYRG EVKVVLFNHS EKDFEIKEGD 

       130        140        150 
RIAQLVLEQI VNADIKEISL EELDNTERGE GGFGSTGKN 

« Hide

References

[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000045 Genomic DNA. Translation: EAK99213.1.
AACQ01000042 Genomic DNA. Translation: EAK99488.1.
PIRS51498.
RefSeqXP_718145.1. XM_713052.1.
XP_718414.1. XM_713321.1.

3D structure databases

ProteinModelPortalP0CY19.
SMRP0CY19. Positions 25-159.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3639915.
3640188.
KEGGcal:CaO19.10832.
cal:CaO19.3322.

Organism-specific databases

CGDCAL0004091. DUT1.

Phylogenomic databases

KOK01520.
OrthoDBEOG7T7H6C.

Enzyme and pathway databases

BRENDA3.6.1.23. 1124.
UniPathwayUPA00610; UER00666.

Family and domain databases

InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDUT_CANAL
AccessionPrimary (citable) accession number: P0CY19
Secondary accession number(s): P43058, Q5A912
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: November 13, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Candida albicans

Candida albicans: entries and gene names