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Protein

Mating-type protein A1

Gene

MATA1

Organism
Saccharomyces cerevisiae (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that, in a/alpha diploid cells, binds cooperatively with the ALPHA2 protein to a 21-bp DNA sequence termed the haploid-specific gene (hsg) operator, to repress transcription of haploid-specific genes and of MATALPHA1.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi70 – 126HomeoboxPROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mating-type protein A1
Short name:
MATa1 protein
Gene namesi
Name:MATA1
Synonyms:MAT1A
OrganismiSaccharomyces cerevisiae (Baker's yeast)
Taxonomic identifieri4932 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Organism-specific databases

SGDiS000029660. MATA1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492011 – 126Mating-type protein A1Add BLAST126

Proteomic databases

PaxDbiP0CY10.
PRIDEiP0CY10.

Expressioni

Developmental stagei

Only present in a-cells and in a/alpha diploid cells.

Interactioni

Subunit structurei

Binds DNA with a high specificity as a heterodimer of A1 and ALPHA2.3 Publications

Protein-protein interaction databases

IntActiP0CY10. 1 interactor.
STRINGi4932.YCR097W.

Structurei

Secondary structure

1126
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi79 – 91Combined sources13
Helixi97 – 107Combined sources11
Helixi111 – 122Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AKHX-ray2.50A66-126[»]
1F43NMR-A66-126[»]
1LE8X-ray2.30A74-126[»]
1MH3X-ray2.10A77-126[»]
1MH4X-ray2.30A77-126[»]
1YRNX-ray2.50A66-126[»]
ProteinModelPortaliP0CY10.
SMRiP0CY10.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CY10.

Family & Domainsi

Sequence similaritiesi

Belongs to the MATA1 family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiENOG410J3QJ. Eukaryota.
ENOG410Y2GC. LUCA.
PhylomeDBiP0CY10.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CY10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDICSMAEN INRTLFNILG TEIDEINLNT NNLYNFIMES NLTKVEQHTL
60 70 80 90 100
HKNISNNRLE IYHHIKKEKS PKGKSSISPQ ARAFLEQVFR RKQSLNSKEK
110 120
EEVAKKCGIT PLQVRVWFIN KRMRSK
Length:126
Mass (Da):14,803
Last modified:June 28, 2011 - v1
Checksum:iB413D0042EB97B3A
GO

Sequence cautioni

The sequence CAA24622 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence described in PubMed:7021055 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01313 Genomic DNA. Translation: CAA24622.1. Sequence problems.
V01312 Genomic DNA. Translation: CAA24619.1.
PIRiA90983. JEBY1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01313 Genomic DNA. Translation: CAA24622.1. Sequence problems.
V01312 Genomic DNA. Translation: CAA24619.1.
PIRiA90983. JEBY1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AKHX-ray2.50A66-126[»]
1F43NMR-A66-126[»]
1LE8X-ray2.30A74-126[»]
1MH3X-ray2.10A77-126[»]
1MH4X-ray2.30A77-126[»]
1YRNX-ray2.50A66-126[»]
ProteinModelPortaliP0CY10.
SMRiP0CY10.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0CY10. 1 interactor.
STRINGi4932.YCR097W.

Proteomic databases

PaxDbiP0CY10.
PRIDEiP0CY10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

SGDiS000029660. MATA1.

Phylogenomic databases

eggNOGiENOG410J3QJ. Eukaryota.
ENOG410Y2GC. LUCA.
PhylomeDBiP0CY10.

Miscellaneous databases

EvolutionaryTraceiP0CY10.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMATA1_YEASX
AccessioniPrimary (citable) accession number: P0CY10
Secondary accession number(s): D6VR98
, P01366, P09091, Q06724
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 30, 2016
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Was initially thought to be alternatively spliced.
This gene is functional with 1, 2 or no introns, but the functional protein is produced only when both introns are spliced from the mRNA.
There are three genetic loci for mating type genes in S.cerevisiae. MAT is the expression locus that determines the mating type of the cell, whereas HML (containing HMLALPHA1 and HMLALPHA2) and HMR (containing HMRA1 and HMRA2) represent silenced repositories of mating type information. The mating type is determined by the MAT locus, which contains either a copy of HML or of HMR. Diploid cells are usually heterozygous for the MAT locus.

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.