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Protein

Mating-type protein A1

Gene

MATA1

Organism
Saccharomyces cerevisiae (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that, in a/alpha diploid cells, binds cooperatively with the ALPHA2 protein to a 21-bp DNA sequence termed the haploid-specific gene (hsg) operator, to repress transcription of haploid-specific genes and of MATALPHA1.1 Publication

Miscellaneous

Was initially thought to be alternatively spliced.
This gene is functional with 1, 2 or no introns, but the functional protein is produced only when both introns are spliced from the mRNA.
There are three genetic loci for mating type genes in S.cerevisiae. MAT is the expression locus that determines the mating type of the cell, whereas HML (containing HMLALPHA1 and HMLALPHA2) and HMR (containing HMRA1 and HMRA2) represent silenced repositories of mating type information. The mating type is determined by the MAT locus, which contains either a copy of HML or of HMR. Diploid cells are usually heterozygous for the MAT locus.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi70 – 126HomeoboxPROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mating-type protein A1
Short name:
MATa1 protein
Gene namesi
Name:MATA1
Synonyms:MAT1A
OrganismiSaccharomyces cerevisiae (Baker's yeast)
Taxonomic identifieri4932 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Organism-specific databases

SGDiS000029660 MATA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492011 – 126Mating-type protein A1Add BLAST126

Proteomic databases

PRIDEiP0CY10

Expressioni

Developmental stagei

Only present in a-cells and in a/alpha diploid cells.

Interactioni

Subunit structurei

Binds DNA with a high specificity as a heterodimer of A1 and ALPHA2.3 Publications

Protein-protein interaction databases

IntActiP0CY10, 1 interactor
MINTiP0CY10

Structurei

Secondary structure

1126
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi79 – 91Combined sources13
Helixi97 – 106Combined sources10
Helixi111 – 123Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AKHX-ray2.50A66-126[»]
1F43NMR-A66-126[»]
1LE8X-ray2.30A74-126[»]
1MH3X-ray2.10A77-126[»]
1MH4X-ray2.30A77-126[»]
1YRNX-ray2.50A66-126[»]
ProteinModelPortaliP0CY10
SMRiP0CY10
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CY10

Family & Domainsi

Sequence similaritiesi

Belongs to the MATA1 family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiENOG410J3QJ Eukaryota
ENOG410Y2GC LUCA
PhylomeDBiP0CY10

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0CY10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDICSMAEN INRTLFNILG TEIDEINLNT NNLYNFIMES NLTKVEQHTL
60 70 80 90 100
HKNISNNRLE IYHHIKKEKS PKGKSSISPQ ARAFLEQVFR RKQSLNSKEK
110 120
EEVAKKCGIT PLQVRVWFIN KRMRSK
Length:126
Mass (Da):14,803
Last modified:June 28, 2011 - v1
Checksum:iB413D0042EB97B3A
GO

Sequence cautioni

The sequence CAA24622 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence described in PubMed:7021055 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01313 Genomic DNA Translation: CAA24622.1 Sequence problems.
V01312 Genomic DNA Translation: CAA24619.1
PIRiA90983 JEBY1

Similar proteinsi

Entry informationi

Entry nameiMATA1_YEASX
AccessioniPrimary (citable) accession number: P0CY10
Secondary accession number(s): D6VR98
, P01366, P09091, Q06724
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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