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Protein

Mating-type protein ALPHA1

Gene

MATALPHA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional coactivator that, in alpha-cells, binds cooperatively with MCM1 and STE12 to a DNA sequence termed the QP' element, to activate the transcription of alpha-specific genes.1 Publication

Miscellaneous

There are three genetic loci for mating type genes in S.cerevisiae. MAT is the expression locus that determines the mating type of the cell, whereas HML (containing HMLALPHA1 and HMLALPHA2) and HMR (containing HMRA1 and HMRA2) represent silenced repositories of mating type information. The mating type is determined by the MAT locus, which contains either a copy of HML or of HMR. Diploid cells are usually heterozygous for the MAT locus.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi88 – 144Alpha boxPROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

  • DNA binding, bending Source: SGD
  • transcription coactivator activity Source: SGD

GO - Biological processi

  • positive regulation of mating-type specific transcription, DNA-templated Source: InterPro
  • regulation of mating-type specific transcription, DNA-templated Source: SGD
  • regulation of transcription by RNA polymerase II Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-29352-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Mating-type protein ALPHA1
Short name:
MATalpha1 protein
Alternative name(s):
Alpha-1 activator
Gene namesi
Name:MATALPHA1
Synonyms:ALPHA-1, MAT1A, MATAL1
Ordered Locus Names:YCR040W
ORF Names:YCR40W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

SGDiS000000636 MATALPHA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000966101 – 175Mating-type protein ALPHA1Add BLAST175

Proteomic databases

PRIDEiP0CY06

Expressioni

Developmental stagei

Only present in alpha-cells.

Inductioni

Repressed in a/alpha diploid cells by A1/ALPHA2.

Interactioni

Subunit structurei

Binds DNA with a high specificity in complex with an MCM1 dimer. Interacts with STE12.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
STE12P135742EBI-10438,EBI-18264

Protein-protein interaction databases

BioGridi30923, 6 interactors
31023, 4 interactors
IntActiP0CY06, 5 interactors
MINTiP0CY06

Structurei

3D structure databases

ProteinModelPortaliP0CY06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MATALPHA1 family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000057084
InParanoidiP0CY06
OrthoDBiEOG092C4Z9U

Family and domain databases

InterProiView protein in InterPro
IPR006856 MATalpha_HMGbox
PfamiView protein in Pfam
PF04769 MATalpha_HMGbox, 1 hit
PROSITEiView protein in PROSITE
PS51325 ALPHA_BOX, 1 hit

Sequencei

Sequence statusi: Complete.

P0CY06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTSKPAFKI KNKASKSYRN TAVSKKLKEK RLAEHVRPSC FNIIRPLKKD
60 70 80 90 100
IQIPVPSSRF LNKIQIHRIA SGSQNTQFRQ FNKTSIKSSK KYLNSFMAFR
110 120 130 140 150
AYYSQFGSGV KQNVLSSLLA EEWHADKMQH GIWDYFAQQY NFINPGFGFV
160 170
EWLTNNYAEV RGDGYWEDVF VHLAL
Length:175
Mass (Da):20,413
Last modified:June 28, 2011 - v1
Checksum:i697199A7686D19C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00060 Genomic DNA Translation: AAA34763.1
X63853 Genomic DNA Translation: CAA45336.1
X59720 Genomic DNA Translation: CAA42401.1
AY692791 Genomic DNA Translation: AAT92810.1
BK006937 Genomic DNA Translation: DAA07422.1
PIRiS19397 JFBYA1
RefSeqiNP_009867.1, NM_001178707.1
NP_009869.3, NM_001178754.1

Genome annotation databases

EnsemblFungiiCAA42401; CAA42401; CAA42401
YCL066W; YCL066W; YCL066W
YCR040W; YCR040W; YCR040W
GeneIDi850293
850407
KEGGisce:YCL066W
sce:YCR040W

Similar proteinsi

Entry informationi

Entry nameiMTAL1_YEAST
AccessioniPrimary (citable) accession number: P0CY06
Secondary accession number(s): D6VQV3, P01365
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

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