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Protein

60S ribosomal protein L41-A

Gene

RPL41A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 11900 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eL41 in yeast.Curated

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-29570-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L41-A1 Publication
Alternative name(s):
L47
Large ribosomal subunit protein eL41-A1 Publication
YL41
Gene namesi
Name:RPL41A1 Publication
Synonyms:RPL47A, YL41A
Ordered Locus Names:YDL184C
ORF Names:D1290
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

SGDiS000002343. RPL41A.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001980741 – 2560S ribosomal protein L41-AAdd BLAST25

Proteomic databases

PRIDEiP0CX86.

Expressioni

Gene expression databases

ExpressionAtlasiP0CX86. differential.

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi31860. 82 interactors.
31928. 44 interactors.
MINTiMINT-4479456.
STRINGi4932.YDL184C.

Structurei

Secondary structure

125
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 24Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10811-25[»]
3J6Yelectron microscopy6.10811-25[»]
3J77electron microscopy6.20911-25[»]
3J78electron microscopy6.30911-25[»]
3J80electron microscopy3.75h1-25[»]
3J81electron microscopy4.00h1-25[»]
3JAMelectron microscopy3.46h1-25[»]
3JAPelectron microscopy4.90h1-25[»]
3JAQelectron microscopy6.00h1-25[»]
4U3MX-ray3.00Q1/q11-25[»]
4U3NX-ray3.20Q1/q11-25[»]
4U3UX-ray2.90Q1/q11-25[»]
4U4NX-ray3.10Q1/q11-25[»]
4U4OX-ray3.60Q1/q11-25[»]
4U4QX-ray3.00Q1/q11-25[»]
4U4RX-ray2.80Q1/q11-25[»]
4U4UX-ray3.00Q1/q11-25[»]
4U4YX-ray3.20Q1/q11-25[»]
4U4ZX-ray3.10Q1/q11-25[»]
4U53X-ray3.30Q1/q11-25[»]
4U55X-ray3.20Q1/q11-25[»]
4U56X-ray3.45Q1/q11-25[»]
4V6Ielectron microscopy8.80Bq1-25[»]
4V88X-ray3.00Bn/Dn1-25[»]
4V8Telectron microscopy8.10n1-25[»]
4V91electron microscopy3.70n1-25[»]
5DATX-ray3.15Q1/q11-25[»]
5DC3X-ray3.25Q1/q11-25[»]
5DGEX-ray3.45Q1/q11-25[»]
5DGFX-ray3.30Q1/q11-25[»]
5DGVX-ray3.10Q1/q11-25[»]
5FCIX-ray3.40Q1/q11-25[»]
5FCJX-ray3.10Q1/q11-25[»]
5GAKelectron microscopy3.88p1-25[»]
5I4LX-ray3.10Q1/q11-25[»]
5IT7electron microscopy3.60nn1-25[»]
5JUOelectron microscopy4.00SA1-25[»]
5JUPelectron microscopy3.50SA1-25[»]
5JUSelectron microscopy4.20SA1-25[»]
5JUTelectron microscopy4.00SA1-25[»]
5JUUelectron microscopy4.00SA1-25[»]
5LYBX-ray3.25Q1/q11-25[»]
5MC6electron microscopy3.80AS1-25[»]
5TGAX-ray3.30Q1/q11-25[»]
5TGMX-ray3.50Q1/q11-25[»]
ProteinModelPortaliP0CX86.
SMRiP0CX86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 23Arg-richAdd BLAST22

Sequence similaritiesi

Phylogenomic databases

KOiK02928.

Family and domain databases

InterProiView protein in InterPro
IPR007836. Ribosomal_L41.
PfamiView protein in Pfam
PF05162. Ribosomal_L41. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CX86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
MRAKWRKKRT RRLKRKRRKV RARSK
Length:25
Mass (Da):3,337
Last modified:June 28, 2011 - v1
Checksum:iBD2629DD9ED85381
GO

Mass spectrometryi

Molecular mass is 3335.103 Da from positions 1 - 25. Determined by ESI. Monoisotopic mass.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16065 Genomic DNA. Translation: CAA34201.1.
X83276 Genomic DNA. Translation: CAA58262.1.
Z74232 Genomic DNA. Translation: CAA98759.1.
AY693059 Genomic DNA. Translation: AAT93078.1.
BK006938 Genomic DNA. Translation: DAA11678.1.
PIRiS22246. R6BY4B.
RefSeqiNP_010097.1. NM_001180244.1.
NP_010148.1. NM_001180194.1.

Genome annotation databases

EnsemblFungiiYDL133C-A; YDL133C-A; YDL133C-A.
YDL184C; YDL184C; YDL184C.
GeneIDi851344.
851422.
KEGGisce:YDL133C-A.
sce:YDL184C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRL41A_YEAST
AccessioniPrimary (citable) accession number: P0CX86
Secondary accession number(s): D6VRG8, P05746
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: July 5, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names