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Protein

60S ribosomal protein L41-A

Gene

RPL41A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: SGD

GO - Biological processi

  1. cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-29570-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L41-A
Alternative name(s):
L47
YL41
Gene namesi
Name:RPL41A
Synonyms:RPL47A, YL41A
Ordered Locus Names:YDL184C
ORF Names:D1290
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDL184c.
SGDiS000002343. RPL41A.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252560S ribosomal protein L41-APRO_0000198074Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiP0CX86. differential.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi31860. 41 interactions.
31928. 20 interactions.
MINTiMINT-4479456.

Structurei

Secondary structure

1
25
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 2220Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VW8electron microscopy6.10o1-25[»]
1VWUelectron microscopy6.10o1-25[»]
1VXVelectron microscopy6.20o1-25[»]
1VXYelectron microscopy6.30o1-25[»]
3IZSelectron microscopy-q1-25[»]
3J80electron microscopy3.75h1-25[»]
3J81electron microscopy4.00h1-25[»]
3U5EX-ray3.00n1-25[»]
3U5IX-ray3.00n1-25[»]
4B6Aelectron microscopy8.10n1-25[»]
4CUWelectron microscopy3.70n1-25[»]
4UJMX-ray3.00a1-25[»]
4UJOX-ray3.00f1-25[»]
4UJRX-ray2.80a1-25[»]
4UJTX-ray2.80f1-25[»]
4UK1X-ray3.00a1-25[»]
4UK3X-ray3.00f1-25[»]
4UK6X-ray3.20a1-25[»]
4UK8X-ray3.20f1-25[»]
4UKBX-ray2.90a1-25[»]
4UKEX-ray2.90f1-25[»]
4UKHX-ray3.45a1-25[»]
4UKJX-ray3.45e1-25[»]
4UKMX-ray3.20a1-25[»]
4UKOX-ray3.20e1-25[»]
4UKRX-ray3.30a1-25[»]
4UKTX-ray3.30f1-25[»]
4UKWX-ray3.10a1-25[»]
4UKYX-ray3.10f1-25[»]
4UL1X-ray3.60a1-25[»]
4UL3X-ray3.60f1-25[»]
4UL6X-ray3.00a1-25[»]
4UL8X-ray3.00f1-25[»]
4ULGX-ray3.20a1-25[»]
4ULIX-ray3.20f1-25[»]
4ULMX-ray3.10a1-25[»]
4ULOX-ray3.10f1-25[»]
4V8Telectron microscopy8.10n1-25[»]
ProteinModelPortaliP0CX86.
SMRiP0CX86. Positions 1-26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 2322Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the ribosomal protein L41e family.Curated

Phylogenomic databases

KOiK02928.

Family and domain databases

InterProiIPR007836. Ribosomal_L41.
[Graphical view]
PfamiPF05162. Ribosomal_L41. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CX86-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20 
MRAKWRKKRT RRLKRKRRKV RARSK
Length:25
Mass (Da):3,337
Last modified:June 28, 2011 - v1
Checksum:iBD2629DD9ED85381
GO

Mass spectrometryi

Molecular mass is 3335.103 Da from positions 1 - 25. Determined by ESI. Monoisotopic mass.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16065 Genomic DNA. Translation: CAA34201.1.
X83276 Genomic DNA. Translation: CAA58262.1.
Z74232 Genomic DNA. Translation: CAA98759.1.
AY693059 Genomic DNA. Translation: AAT93078.1.
BK006938 Genomic DNA. Translation: DAA11678.1.
PIRiS22246. R6BY4B.
RefSeqiNP_010097.1. NM_001180244.1.
NP_010148.1. NM_001180194.1.

Genome annotation databases

EnsemblFungiiYDL133C-A; YDL133C-A; YDL133C-A.
YDL184C; YDL184C; YDL184C.
GeneIDi851344.
851422.
KEGGisce:YDL133C-A.
sce:YDL184C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16065 Genomic DNA. Translation: CAA34201.1.
X83276 Genomic DNA. Translation: CAA58262.1.
Z74232 Genomic DNA. Translation: CAA98759.1.
AY693059 Genomic DNA. Translation: AAT93078.1.
BK006938 Genomic DNA. Translation: DAA11678.1.
PIRiS22246. R6BY4B.
RefSeqiNP_010097.1. NM_001180244.1.
NP_010148.1. NM_001180194.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VW8electron microscopy6.10o1-25[»]
1VWUelectron microscopy6.10o1-25[»]
1VXVelectron microscopy6.20o1-25[»]
1VXYelectron microscopy6.30o1-25[»]
3IZSelectron microscopy-q1-25[»]
3J80electron microscopy3.75h1-25[»]
3J81electron microscopy4.00h1-25[»]
3U5EX-ray3.00n1-25[»]
3U5IX-ray3.00n1-25[»]
4B6Aelectron microscopy8.10n1-25[»]
4CUWelectron microscopy3.70n1-25[»]
4UJMX-ray3.00a1-25[»]
4UJOX-ray3.00f1-25[»]
4UJRX-ray2.80a1-25[»]
4UJTX-ray2.80f1-25[»]
4UK1X-ray3.00a1-25[»]
4UK3X-ray3.00f1-25[»]
4UK6X-ray3.20a1-25[»]
4UK8X-ray3.20f1-25[»]
4UKBX-ray2.90a1-25[»]
4UKEX-ray2.90f1-25[»]
4UKHX-ray3.45a1-25[»]
4UKJX-ray3.45e1-25[»]
4UKMX-ray3.20a1-25[»]
4UKOX-ray3.20e1-25[»]
4UKRX-ray3.30a1-25[»]
4UKTX-ray3.30f1-25[»]
4UKWX-ray3.10a1-25[»]
4UKYX-ray3.10f1-25[»]
4UL1X-ray3.60a1-25[»]
4UL3X-ray3.60f1-25[»]
4UL6X-ray3.00a1-25[»]
4UL8X-ray3.00f1-25[»]
4ULGX-ray3.20a1-25[»]
4ULIX-ray3.20f1-25[»]
4ULMX-ray3.10a1-25[»]
4ULOX-ray3.10f1-25[»]
4V8Telectron microscopy8.10n1-25[»]
ProteinModelPortaliP0CX86.
SMRiP0CX86. Positions 1-26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31860. 41 interactions.
31928. 20 interactions.
MINTiMINT-4479456.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL133C-A; YDL133C-A; YDL133C-A.
YDL184C; YDL184C; YDL184C.
GeneIDi851344.
851422.
KEGGisce:YDL133C-A.
sce:YDL184C.

Organism-specific databases

CYGDiYDL184c.
SGDiS000002343. RPL41A.

Phylogenomic databases

KOiK02928.

Enzyme and pathway databases

BioCyciYEAST:G3O-29570-MONOMER.

Miscellaneous databases

NextBioi968423.

Gene expression databases

ExpressionAtlasiP0CX86. differential.

Family and domain databases

InterProiIPR007836. Ribosomal_L41.
[Graphical view]
PfamiPF05162. Ribosomal_L41. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Yeast ribosomal proteins. VIII. Isolation of two proteins and sequence characterization of twenty-four proteins from cytoplasmic ribosomes."
    Otaka E., Higo K., Itoh T.
    Mol. Gen. Genet. 195:544-546(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
  2. "Yeast ribosomal proteins: XI. Molecular analysis of two genes encoding YL41, an extremely small and basic ribosomal protein, from Saccharomyces cerevisiae."
    Suzuki K., Hashimoto T., Otaka E.
    Curr. Genet. 17:185-190(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "New open reading frames, one of which is similar to the nifV gene of Azotobacter vinelandii, found on a 12.5 kbp fragment of chromosome IV of Saccharomyces cerevisiae."
    Verhasselt P., Voet M., Volckaert G.
    Yeast 11:961-966(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  8. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  9. "Direct mass spectrometric analysis of intact proteins of the yeast large ribosomal subunit using capillary LC/FTICR."
    Lee S.-W., Berger S.J., Martinovic S., Pasa-Tolic L., Anderson G.A., Shen Y., Zhao R., Smith R.D.
    Proc. Natl. Acad. Sci. U.S.A. 99:5942-5947(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: MASS SPECTROMETRY.
  10. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  11. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  12. "Crystal structure of the eukaryotic ribosome."
    Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
    Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
  13. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL41A_YEAST
AccessioniPrimary (citable) accession number: P0CX86
Secondary accession number(s): D6VRG8, P05746
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: February 4, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 11900 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for L41 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.