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P0CX86

- RL41A_YEAST

UniProt

P0CX86 - RL41A_YEAST

Protein

60S ribosomal protein L41-A

Gene

RPL41A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29570-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L41-A
    Alternative name(s):
    L47
    YL41
    Gene namesi
    Name:RPL41A
    Synonyms:RPL47A, YL41A
    Ordered Locus Names:YDL184C
    ORF Names:D1290
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDL184c.
    SGDiS000002343. RPL41A.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 252560S ribosomal protein L41-APRO_0000198074Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi31860. 41 interactions.
    31928. 20 interactions.
    MINTiMINT-4479456.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VW8electron microscopy6.10o1-25[»]
    1VWUelectron microscopy6.10o1-25[»]
    3IZSelectron microscopy-q1-25[»]
    3U5EX-ray3.00n1-25[»]
    3U5IX-ray3.00n1-25[»]
    4B6Aelectron microscopy8.10n1-25[»]
    4CUWelectron microscopy3.70n1-25[»]
    ProteinModelPortaliP0CX86.
    SMRiP0CX86. Positions 1-26.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 2322Arg-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ribosomal protein L41e family.Curated

    Phylogenomic databases

    KOiK02928.

    Family and domain databases

    InterProiIPR007836. Ribosomal_L41.
    [Graphical view]
    PfamiPF05162. Ribosomal_L41. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CX86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRAKWRKKRT RRLKRKRRKV RARSK                              25
    Length:25
    Mass (Da):3,337
    Last modified:June 28, 2011 - v1
    Checksum:iBD2629DD9ED85381
    GO

    Mass spectrometryi

    Molecular mass is 3335.103 Da from positions 1 - 25. Determined by ESI. Monoisotopic mass.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16065 Genomic DNA. Translation: CAA34201.1.
    X83276 Genomic DNA. Translation: CAA58262.1.
    Z74232 Genomic DNA. Translation: CAA98759.1.
    AY693059 Genomic DNA. Translation: AAT93078.1.
    BK006938 Genomic DNA. Translation: DAA11678.1.
    PIRiS22246. R6BY4B.
    RefSeqiNP_010097.1. NM_001180244.1.
    NP_010148.1. NM_001180194.1.

    Genome annotation databases

    EnsemblFungiiYDL133C-A; YDL133C-A; YDL133C-A.
    YDL184C; YDL184C; YDL184C.
    GeneIDi851344.
    851422.
    KEGGisce:YDL133C-A.
    sce:YDL184C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16065 Genomic DNA. Translation: CAA34201.1 .
    X83276 Genomic DNA. Translation: CAA58262.1 .
    Z74232 Genomic DNA. Translation: CAA98759.1 .
    AY693059 Genomic DNA. Translation: AAT93078.1 .
    BK006938 Genomic DNA. Translation: DAA11678.1 .
    PIRi S22246. R6BY4B.
    RefSeqi NP_010097.1. NM_001180244.1.
    NP_010148.1. NM_001180194.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VW8 electron microscopy 6.10 o 1-25 [» ]
    1VWU electron microscopy 6.10 o 1-25 [» ]
    3IZS electron microscopy - q 1-25 [» ]
    3U5E X-ray 3.00 n 1-25 [» ]
    3U5I X-ray 3.00 n 1-25 [» ]
    4B6A electron microscopy 8.10 n 1-25 [» ]
    4CUW electron microscopy 3.70 n 1-25 [» ]
    ProteinModelPortali P0CX86.
    SMRi P0CX86. Positions 1-26.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31860. 41 interactions.
    31928. 20 interactions.
    MINTi MINT-4479456.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDL133C-A ; YDL133C-A ; YDL133C-A .
    YDL184C ; YDL184C ; YDL184C .
    GeneIDi 851344.
    851422.
    KEGGi sce:YDL133C-A.
    sce:YDL184C.

    Organism-specific databases

    CYGDi YDL184c.
    SGDi S000002343. RPL41A.

    Phylogenomic databases

    KOi K02928.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29570-MONOMER.

    Miscellaneous databases

    NextBioi 968423.

    Family and domain databases

    InterProi IPR007836. Ribosomal_L41.
    [Graphical view ]
    Pfami PF05162. Ribosomal_L41. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Yeast ribosomal proteins. VIII. Isolation of two proteins and sequence characterization of twenty-four proteins from cytoplasmic ribosomes."
      Otaka E., Higo K., Itoh T.
      Mol. Gen. Genet. 195:544-546(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
    2. "Yeast ribosomal proteins: XI. Molecular analysis of two genes encoding YL41, an extremely small and basic ribosomal protein, from Saccharomyces cerevisiae."
      Suzuki K., Hashimoto T., Otaka E.
      Curr. Genet. 17:185-190(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "New open reading frames, one of which is similar to the nifV gene of Azotobacter vinelandii, found on a 12.5 kbp fragment of chromosome IV of Saccharomyces cerevisiae."
      Verhasselt P., Voet M., Volckaert G.
      Yeast 11:961-966(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    8. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    9. "Direct mass spectrometric analysis of intact proteins of the yeast large ribosomal subunit using capillary LC/FTICR."
      Lee S.-W., Berger S.J., Martinovic S., Pasa-Tolic L., Anderson G.A., Shen Y., Zhao R., Smith R.D.
      Proc. Natl. Acad. Sci. U.S.A. 99:5942-5947(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: MASS SPECTROMETRY.
    10. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    11. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    12. "Crystal structure of the eukaryotic ribosome."
      Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
      Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
    13. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL41A_YEAST
    AccessioniPrimary (citable) accession number: P0CX86
    Secondary accession number(s): D6VRG8, P05746
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 11900 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for L41 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3