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Protein

60S ribosomal protein L35-A

Gene

RPL35A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-29576-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L35-A
Gene namesi
Name:RPL35A
Synonyms:SOS1
Ordered Locus Names:YDL191W
ORF Names:D1249
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

SGDiS000002350. RPL35A.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD
  • preribosome, large subunit precursor Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 12011960S ribosomal protein L35-APRO_0000130552Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineCombined sources
Modified residuei50 – 501PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP0CX84.

PTM databases

iPTMnetiP0CX84.

Expressioni

Gene expression databases

ExpressionAtlasiP0CX84. differential.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi31854. 103 interactions.
31925. 79 interactions.
IntActiP0CX84. 1 interaction.
MINTiMINT-8285624.

Structurei

Secondary structure

1
120
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 94Combined sources
Helixi14 – 3522Combined sources
Helixi43 – 6826Combined sources
Turni69 – 724Combined sources
Helixi78 – 803Combined sources
Helixi86 – 894Combined sources
Helixi94 – 985Combined sources
Helixi102 – 1109Combined sources
Beta strandi116 – 1183Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-Y2-60[»]
2WW9electron microscopy8.60N1-120[»]
2WWAelectron microscopy8.90N1-120[»]
2WWBelectron microscopy6.48N1-120[»]
3J6Xelectron microscopy6.10751-120[»]
3J6Yelectron microscopy6.10751-120[»]
3J77electron microscopy6.20851-120[»]
3J78electron microscopy6.30851-120[»]
3JCTelectron microscopy3.08h1-120[»]
4U3MX-ray3.00O5/o52-120[»]
4U3NX-ray3.20O5/o52-120[»]
4U3UX-ray2.90O5/o52-120[»]
4U4NX-ray3.10O5/o52-120[»]
4U4OX-ray3.60O5/o52-120[»]
4U4QX-ray3.00O5/o52-120[»]
4U4RX-ray2.80O5/o52-120[»]
4U4UX-ray3.00O5/o52-120[»]
4U4YX-ray3.20O5/o52-120[»]
4U4ZX-ray3.10O5/o52-120[»]
4U50X-ray3.20O5/o52-120[»]
4U51X-ray3.20O5/o52-120[»]
4U52X-ray3.00O5/o52-120[»]
4U53X-ray3.30O5/o52-120[»]
4U55X-ray3.20O5/o52-120[»]
4U56X-ray3.45O5/o52-120[»]
4U6FX-ray3.10O5/o52-120[»]
4V4Belectron microscopy11.70BX1-120[»]
4V6Ielectron microscopy8.80Bc1-120[»]
4V7Felectron microscopy8.70Z1-120[»]
4V7RX-ray4.00Bc/Dc1-120[»]
4V88X-ray3.00Bh/Dh1-120[»]
4V8Telectron microscopy8.10h1-120[»]
4V91electron microscopy3.70h1-120[»]
5APNelectron microscopy3.91h1-120[»]
5APOelectron microscopy3.41h1-120[»]
5DC3X-ray3.25O5/o52-120[»]
5FCIX-ray3.40O5/o52-120[»]
5FCJX-ray3.10O5/o52-120[»]
5FL8electron microscopy9.50h1-120[»]
5GAKelectron microscopy3.88j1-120[»]
5I4LX-ray3.10O5/o52-120[»]
ProteinModelPortaliP0CX84.
SMRiP0CX84. Positions 1-69.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CX84.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L29P family.Curated

Phylogenomic databases

InParanoidiP0CX84.
KOiK02918.
OrthoDBiEOG092C5O2N.

Family and domain databases

CDDicd00427. Ribosomal_L29_HIP. 1 hit.
Gene3Di1.10.287.310. 1 hit.
HAMAPiMF_00374. Ribosomal_L29. 1 hit.
InterProiIPR001854. Ribosomal_L29.
IPR018254. Ribosomal_L29_CS.
[Graphical view]
PfamiPF00831. Ribosomal_L29. 1 hit.
[Graphical view]
SUPFAMiSSF46561. SSF46561. 1 hit.
TIGRFAMsiTIGR00012. L29. 1 hit.
PROSITEiPS00579. RIBOSOMAL_L29. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CX84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVKAYELR TKSKEQLASQ LVDLKKELAE LKVQKLSRPS LPKIKTVRKS
60 70 80 90 100
IACVLTVINE QQREAVRQLY KGKKYQPKDL RAKKTRALRR ALTKFEASQV
110 120
TEKQRKKQIA FPQRKYAIKA
Length:120
Mass (Da):13,910
Last modified:June 28, 2011 - v1
Checksum:iD8AC9DF157AD2AD6
GO

Mass spectrometryi

Molecular mass is 13769.991 Da from positions 2 - 120. Determined by ESI. Monoisotopic mass.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82913 Genomic DNA. Translation: AAA34492.1.
X83276 Genomic DNA. Translation: CAA58256.1.
Z74239 Genomic DNA. Translation: CAA98768.1.
BK006938 Genomic DNA. Translation: DAA11722.1.
PIRiS30770.
RefSeqiNP_010090.1. NM_001180251.2.
NP_010145.1. NM_001180196.2.

Genome annotation databases

EnsemblFungiiYDL136W; YDL136W; YDL136W.
YDL191W; YDL191W; YDL191W.
GeneIDi851336.
851419.
KEGGisce:YDL136W.
sce:YDL191W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82913 Genomic DNA. Translation: AAA34492.1.
X83276 Genomic DNA. Translation: CAA58256.1.
Z74239 Genomic DNA. Translation: CAA98768.1.
BK006938 Genomic DNA. Translation: DAA11722.1.
PIRiS30770.
RefSeqiNP_010090.1. NM_001180251.2.
NP_010145.1. NM_001180196.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-Y2-60[»]
2WW9electron microscopy8.60N1-120[»]
2WWAelectron microscopy8.90N1-120[»]
2WWBelectron microscopy6.48N1-120[»]
3J6Xelectron microscopy6.10751-120[»]
3J6Yelectron microscopy6.10751-120[»]
3J77electron microscopy6.20851-120[»]
3J78electron microscopy6.30851-120[»]
3JCTelectron microscopy3.08h1-120[»]
4U3MX-ray3.00O5/o52-120[»]
4U3NX-ray3.20O5/o52-120[»]
4U3UX-ray2.90O5/o52-120[»]
4U4NX-ray3.10O5/o52-120[»]
4U4OX-ray3.60O5/o52-120[»]
4U4QX-ray3.00O5/o52-120[»]
4U4RX-ray2.80O5/o52-120[»]
4U4UX-ray3.00O5/o52-120[»]
4U4YX-ray3.20O5/o52-120[»]
4U4ZX-ray3.10O5/o52-120[»]
4U50X-ray3.20O5/o52-120[»]
4U51X-ray3.20O5/o52-120[»]
4U52X-ray3.00O5/o52-120[»]
4U53X-ray3.30O5/o52-120[»]
4U55X-ray3.20O5/o52-120[»]
4U56X-ray3.45O5/o52-120[»]
4U6FX-ray3.10O5/o52-120[»]
4V4Belectron microscopy11.70BX1-120[»]
4V6Ielectron microscopy8.80Bc1-120[»]
4V7Felectron microscopy8.70Z1-120[»]
4V7RX-ray4.00Bc/Dc1-120[»]
4V88X-ray3.00Bh/Dh1-120[»]
4V8Telectron microscopy8.10h1-120[»]
4V91electron microscopy3.70h1-120[»]
5APNelectron microscopy3.91h1-120[»]
5APOelectron microscopy3.41h1-120[»]
5DC3X-ray3.25O5/o52-120[»]
5FCIX-ray3.40O5/o52-120[»]
5FCJX-ray3.10O5/o52-120[»]
5FL8electron microscopy9.50h1-120[»]
5GAKelectron microscopy3.88j1-120[»]
5I4LX-ray3.10O5/o52-120[»]
ProteinModelPortaliP0CX84.
SMRiP0CX84. Positions 1-69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31854. 103 interactions.
31925. 79 interactions.
IntActiP0CX84. 1 interaction.
MINTiMINT-8285624.

PTM databases

iPTMnetiP0CX84.

Proteomic databases

MaxQBiP0CX84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL136W; YDL136W; YDL136W.
YDL191W; YDL191W; YDL191W.
GeneIDi851336.
851419.
KEGGisce:YDL136W.
sce:YDL191W.

Organism-specific databases

SGDiS000002350. RPL35A.

Phylogenomic databases

InParanoidiP0CX84.
KOiK02918.
OrthoDBiEOG092C5O2N.

Enzyme and pathway databases

BioCyciYEAST:G3O-29576-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

EvolutionaryTraceiP0CX84.
PROiP0CX84.

Gene expression databases

ExpressionAtlasiP0CX84. differential.

Family and domain databases

CDDicd00427. Ribosomal_L29_HIP. 1 hit.
Gene3Di1.10.287.310. 1 hit.
HAMAPiMF_00374. Ribosomal_L29. 1 hit.
InterProiIPR001854. Ribosomal_L29.
IPR018254. Ribosomal_L29_CS.
[Graphical view]
PfamiPF00831. Ribosomal_L29. 1 hit.
[Graphical view]
SUPFAMiSSF46561. SSF46561. 1 hit.
TIGRFAMsiTIGR00012. L29. 1 hit.
PROSITEiPS00579. RIBOSOMAL_L29. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL35A_YEAST
AccessioniPrimary (citable) accession number: P0CX84
Secondary accession number(s): D6VRG2, P39741, P39930
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 7, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 2 genes for L35 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.