Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L19-B

Gene

RPL19B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-28930-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L19-B
Alternative name(s):
L23
RP15L
RP33
YL14
Gene namesi
Name:RPL19B
Synonyms:RPL23B, YL14B
Ordered Locus Names:YBL027W
ORF Names:YBL0424
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

SGDiS000000123. RPL19B.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved2 Publications
Chaini2 – 18918860S ribosomal protein L19-BPRO_0000410446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki21 – 21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei30 – 301PhosphoserineCombined sources
Modified residuei37 – 371PhosphoserineCombined sources
Cross-linki53 – 53Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki60 – 60Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei91 – 911PhosphoserineCombined sources
Cross-linki146 – 146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki186 – 186Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

PTM databases

iPTMnetiP0CX83.

Expressioni

Gene expression databases

ExpressionAtlasiP0CX83. differential.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi32671. 79 interactions.
32789. 41 interactions.
IntActiP0CX83. 3 interactions.
MINTiMINT-519961.

Chemistry

BindingDBiP0CX83.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V8Telectron microscopy8.10R1-189[»]
4V8Yelectron microscopy4.30BR2-189[»]
4V8Zelectron microscopy6.60BR2-189[»]
ProteinModelPortaliP0CX83.
SMRiP0CX83. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L19e family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000012628.
InParanoidiP0CX83.
KOiK02885.
OrthoDBiEOG092C00Q9.

Family and domain databases

Gene3Di1.10.1200.60. 1 hit.
1.10.1650.10. 1 hit.
HAMAPiMF_01475. Ribosomal_L19e. 1 hit.
InterProiIPR027547. Ribosomal_L19/L19e.
IPR023638. Ribosomal_L19/L19e_CS.
IPR000196. Ribosomal_L19/L19e_dom.
IPR015972. Ribosomal_L19/L19e_dom1.
IPR015974. Ribosomal_L19/L19e_dom3.
[Graphical view]
PfamiPF01280. Ribosomal_L19e. 1 hit.
[Graphical view]
SMARTiSM01416. Ribosomal_L19e. 1 hit.
[Graphical view]
SUPFAMiSSF48140. SSF48140. 1 hit.
PROSITEiPS00526. RIBOSOMAL_L19E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CX83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLRTQKRL AASVVGVGKR KVWLDPNETS EIAQANSRNA IRKLVKNGTI
60 70 80 90 100
VKKAVTVHSK SRTRAHAQSK REGRHSGYGK RKGTREARLP SQVVWIRRLR
110 120 130 140 150
VLRRLLAKYR DAGKIDKHLY HVLYKESKGN AFKHKRALVE HIIQAKADAQ
160 170 180
REKALNEEAE ARRLKNRAAR DRRAQRVAEK RDALLKEDA
Length:189
Mass (Da):21,704
Last modified:June 28, 2011 - v1
Checksum:i776C3AB3D348EE99
GO

Sequence cautioni

The sequence CAA54504 differs from that shown. Reason: Erroneous gene model prediction. Curated

Mass spectrometryi

Molecular mass is 21573.159 Da from positions 2 - 189. Determined by ESI. Average mass.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16015 Genomic DNA. Translation: AAB60318.1.
D17338 mRNA. Translation: BAA04156.1.
X77291 Genomic DNA. Translation: CAA54504.1. Sequence problems.
Z35788 Genomic DNA. Translation: CAA84846.1.
BK006936 Genomic DNA. Translation: DAA07093.1.
PIRiS44597.
RefSeqiNP_009526.1. NM_001178267.1.
NP_009641.1. NM_001180057.1.

Genome annotation databases

EnsemblFungiiYBL027W; YBL027W; YBL027W.
YBR084C-A; YBR084C-A; YBR084C-A.
GeneIDi852254.
852379.
KEGGisce:YBL027W.
sce:YBR084C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16015 Genomic DNA. Translation: AAB60318.1.
D17338 mRNA. Translation: BAA04156.1.
X77291 Genomic DNA. Translation: CAA54504.1. Sequence problems.
Z35788 Genomic DNA. Translation: CAA84846.1.
BK006936 Genomic DNA. Translation: DAA07093.1.
PIRiS44597.
RefSeqiNP_009526.1. NM_001178267.1.
NP_009641.1. NM_001180057.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V8Telectron microscopy8.10R1-189[»]
4V8Yelectron microscopy4.30BR2-189[»]
4V8Zelectron microscopy6.60BR2-189[»]
ProteinModelPortaliP0CX83.
SMRiP0CX83. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32671. 79 interactions.
32789. 41 interactions.
IntActiP0CX83. 3 interactions.
MINTiMINT-519961.

Chemistry

BindingDBiP0CX83.

PTM databases

iPTMnetiP0CX83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBL027W; YBL027W; YBL027W.
YBR084C-A; YBR084C-A; YBR084C-A.
GeneIDi852254.
852379.
KEGGisce:YBL027W.
sce:YBR084C-A.

Organism-specific databases

SGDiS000000123. RPL19B.

Phylogenomic databases

GeneTreeiENSGT00390000012628.
InParanoidiP0CX83.
KOiK02885.
OrthoDBiEOG092C00Q9.

Enzyme and pathway databases

BioCyciYEAST:G3O-28930-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP0CX83.

Gene expression databases

ExpressionAtlasiP0CX83. differential.

Family and domain databases

Gene3Di1.10.1200.60. 1 hit.
1.10.1650.10. 1 hit.
HAMAPiMF_01475. Ribosomal_L19e. 1 hit.
InterProiIPR027547. Ribosomal_L19/L19e.
IPR023638. Ribosomal_L19/L19e_CS.
IPR000196. Ribosomal_L19/L19e_dom.
IPR015972. Ribosomal_L19/L19e_dom1.
IPR015974. Ribosomal_L19/L19e_dom3.
[Graphical view]
PfamiPF01280. Ribosomal_L19e. 1 hit.
[Graphical view]
SMARTiSM01416. Ribosomal_L19e. 1 hit.
[Graphical view]
SUPFAMiSSF48140. SSF48140. 1 hit.
PROSITEiPS00526. RIBOSOMAL_L19E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL19B_YEAST
AccessioniPrimary (citable) accession number: P0CX83
Secondary accession number(s): D6VPX3, P05735
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 7, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 225000 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for L19 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.