Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0CX82

- RL19A_YEAST

UniProt

P0CX82 - RL19A_YEAST

Protein

60S ribosomal protein L19-A

Gene

RPL19A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29228-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L19-A
    Alternative name(s):
    L23
    RP15L
    RP33
    YL14
    Gene namesi
    Name:RPL19A
    Synonyms:RPL23A, YL14A
    Ordered Locus Names:YBR084C-A
    ORF Names:YBR084BC
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    SGDiS000002156. RPL19A.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 18918860S ribosomal protein L19-APRO_0000131184Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei30 – 301Phosphoserine1 Publication
    Modified residuei37 – 371Phosphoserine1 Publication
    Modified residuei91 – 911Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP0CX82.

    Interactioni

    Subunit structurei

    Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi32671. 129 interactions.
    32789. 37 interactions.
    IntActiP0CX82. 1 interaction.
    MINTiMINT-8285580.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K5Ymodel-P3-143[»]
    1S1Ielectron microscopy11.70P2-143[»]
    1VW8electron microscopy6.10S1-189[»]
    1VWUelectron microscopy6.10S1-189[»]
    2WW9electron microscopy8.60J1-189[»]
    2WWAelectron microscopy8.90J1-189[»]
    3IZSelectron microscopy-T1-189[»]
    3J65electron microscopy8.70R1-189[»]
    3O58X-ray4.00S1-189[»]
    3O5HX-ray4.00S1-189[»]
    3U5EX-ray3.00R1-189[»]
    3U5IX-ray3.00R1-189[»]
    4CUWelectron microscopy3.70R1-189[»]
    ProteinModelPortaliP0CX82.
    SMRiP0CX82. Positions 2-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0CX82.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L19e family.Curated

    Phylogenomic databases

    KOiK02885.
    OrthoDBiEOG7FJH7S.

    Family and domain databases

    Gene3Di1.10.1200.60. 1 hit.
    1.10.1650.10. 1 hit.
    HAMAPiMF_01475. Ribosomal_L19e.
    InterProiIPR027547. Ribosomal_L19/L19e.
    IPR023638. Ribosomal_L19/L19e_CS.
    IPR000196. Ribosomal_L19/L19e_dom.
    IPR015972. Ribosomal_L19/L19e_dom1.
    IPR015974. Ribosomal_L19/L19e_dom3.
    [Graphical view]
    PfamiPF01280. Ribosomal_L19e. 1 hit.
    [Graphical view]
    SUPFAMiSSF48140. SSF48140. 1 hit.
    PROSITEiPS00526. RIBOSOMAL_L19E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0CX82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANLRTQKRL AASVVGVGKR KVWLDPNETS EIAQANSRNA IRKLVKNGTI    50
    VKKAVTVHSK SRTRAHAQSK REGRHSGYGK RKGTREARLP SQVVWIRRLR 100
    VLRRLLAKYR DAGKIDKHLY HVLYKESKGN AFKHKRALVE HIIQAKADAQ 150
    REKALNEEAE ARRLKNRAAR DRRAQRVAEK RDALLKEDA 189
    Length:189
    Mass (Da):21,704
    Last modified:June 28, 2011 - v1
    Checksum:i776C3AB3D348EE99
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 541A → S in J03724. (PubMed:2836393)Curated

    Mass spectrometryi

    Molecular mass is 21573.159 Da from positions 2 - 189. Determined by ESI. Average mass.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36751 Genomic DNA. Translation: CAA85322.1.
    D17337 mRNA. Translation: BAA04155.1.
    Z35953 Genomic DNA. Translation: CAA85030.1.
    Z35954 Genomic DNA. Translation: CAA85032.1.
    J03724 Genomic DNA. No translation available.
    BK006936 Genomic DNA. Translation: DAA07204.1.
    PIRiS44597.
    RefSeqiNP_009526.1. NM_001178267.1.
    NP_009641.1. NM_001180057.1.

    Genome annotation databases

    EnsemblFungiiYBL027W; YBL027W; YBL027W.
    YBR084C-A; YBR084C-A; YBR084C-A.
    GeneIDi852254.
    852379.
    KEGGisce:YBL027W.
    sce:YBR084C-A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36751 Genomic DNA. Translation: CAA85322.1 .
    D17337 mRNA. Translation: BAA04155.1 .
    Z35953 Genomic DNA. Translation: CAA85030.1 .
    Z35954 Genomic DNA. Translation: CAA85032.1 .
    J03724 Genomic DNA. No translation available.
    BK006936 Genomic DNA. Translation: DAA07204.1 .
    PIRi S44597.
    RefSeqi NP_009526.1. NM_001178267.1.
    NP_009641.1. NM_001180057.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K5Y model - P 3-143 [» ]
    1S1I electron microscopy 11.70 P 2-143 [» ]
    1VW8 electron microscopy 6.10 S 1-189 [» ]
    1VWU electron microscopy 6.10 S 1-189 [» ]
    2WW9 electron microscopy 8.60 J 1-189 [» ]
    2WWA electron microscopy 8.90 J 1-189 [» ]
    3IZS electron microscopy - T 1-189 [» ]
    3J65 electron microscopy 8.70 R 1-189 [» ]
    3O58 X-ray 4.00 S 1-189 [» ]
    3O5H X-ray 4.00 S 1-189 [» ]
    3U5E X-ray 3.00 R 1-189 [» ]
    3U5I X-ray 3.00 R 1-189 [» ]
    4CUW electron microscopy 3.70 R 1-189 [» ]
    ProteinModelPortali P0CX82.
    SMRi P0CX82. Positions 2-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32671. 129 interactions.
    32789. 37 interactions.
    IntActi P0CX82. 1 interaction.
    MINTi MINT-8285580.

    Chemistry

    BindingDBi P0CX82.
    ChEMBLi CHEMBL1741172.

    Proteomic databases

    MaxQBi P0CX82.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBL027W ; YBL027W ; YBL027W .
    YBR084C-A ; YBR084C-A ; YBR084C-A .
    GeneIDi 852254.
    852379.
    KEGGi sce:YBL027W.
    sce:YBR084C-A.

    Organism-specific databases

    SGDi S000002156. RPL19A.

    Phylogenomic databases

    KOi K02885.
    OrthoDBi EOG7FJH7S.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29228-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    EvolutionaryTracei P0CX82.
    NextBioi 970832.

    Family and domain databases

    Gene3Di 1.10.1200.60. 1 hit.
    1.10.1650.10. 1 hit.
    HAMAPi MF_01475. Ribosomal_L19e.
    InterProi IPR027547. Ribosomal_L19/L19e.
    IPR023638. Ribosomal_L19/L19e_CS.
    IPR000196. Ribosomal_L19/L19e_dom.
    IPR015972. Ribosomal_L19/L19e_dom1.
    IPR015974. Ribosomal_L19/L19e_dom3.
    [Graphical view ]
    Pfami PF01280. Ribosomal_L19e. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48140. SSF48140. 1 hit.
    PROSITEi PS00526. RIBOSOMAL_L19E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and characterization of the Saccharomyces cerevisiae RPL19A gene encoding a homolog of the mammalian ribosomal protein L19."
      Song J.M., Cheung E., Rabinowitz J.C.
      Yeast 11:383-389(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Suzuki K., Tomiyoshi A., Otaka E.
      Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ATCC 204508 / S288c.
    3. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "Yeast ribosomal proteins: VII. Cytoplasmic ribosomal proteins from Schizosaccharomyces pombe."
      Otaka E., Higo K., Itoh T.
      Mol. Gen. Genet. 191:519-524(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-31.
    6. "NH2-terminal acetylation of ribosomal proteins of Saccharomyces cerevisiae."
      Takakura H., Tsunasawa S., Miyagi M., Warner J.R.
      J. Biol. Chem. 267:5442-5445(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-21.
    7. "Isolation and characterization of the Saccharomyces cerevisiae MIS1 gene encoding mitochondrial C1-tetrahydrofolate synthase."
      Shannon K.W., Rabinowitz J.C.
      J. Biol. Chem. 263:7717-7725(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-189.
    8. "Identification of protein coding regions by database similarity search."
      Gish W., States D.J.
      Nat. Genet. 3:266-272(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    9. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    10. "Direct mass spectrometric analysis of intact proteins of the yeast large ribosomal subunit using capillary LC/FTICR."
      Lee S.-W., Berger S.J., Martinovic S., Pasa-Tolic L., Anderson G.A., Shen Y., Zhao R., Smith R.D.
      Proc. Natl. Acad. Sci. U.S.A. 99:5942-5947(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: MASS SPECTROMETRY.
    11. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    12. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    13. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    14. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30; SER-37 AND SER-91, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
      Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
      Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 3-143, ELECTRON MICROSCOPY.
    18. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
      Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
      EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.
    19. "Crystal structure of the eukaryotic ribosome."
      Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
      Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
    20. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL19A_YEAST
    AccessioniPrimary (citable) accession number: P0CX82
    Secondary accession number(s): D6VPX3, P05735
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 97700 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for L19 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3