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Protein

Copper metallothionein 1-1

Gene

CUP1-1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protects the cell against copper toxicity by tightly chelating copper ions. May also act as a depository for copper designated for the effective transfer into the apo forms of copper proteins.

Miscellaneous

There are 2 copies for copper thionein in yeast. The 2 identical copies CUP1-1 and CUP1-2 are arranged in tandem.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi15Copper 11
Metal bindingi15Copper 21
Metal bindingi17Copper 11
Metal bindingi17Copper 31
Metal bindingi19Copper 41
Metal bindingi19Copper 51
Metal bindingi22Copper 31
Metal bindingi22Copper 41
Metal bindingi22Copper 61
Metal bindingi28Copper 21
Metal bindingi28Copper 61
Metal bindingi32Copper 11
Metal bindingi32Copper 71
Metal bindingi34Copper 31
Metal bindingi34Copper 71
Metal bindingi34Copper 81
Metal bindingi38Copper 51
Metal bindingi38Copper 81
Metal bindingi44Copper 41
Metal bindingi44Copper 81
Metal bindingi46Copper 61
Metal bindingi46Copper 71

GO - Molecular functioni

  • antioxidant activity Source: SGD
  • cadmium ion binding Source: SGD
  • copper ion binding Source: SGD
  • superoxide dismutase activity Source: SGD

GO - Biological processi

  • detoxification of cadmium ion Source: SGD
  • detoxification of copper ion Source: SGD
  • removal of superoxide radicals Source: SGD
  • response to copper ion Source: SGD

Keywordsi

LigandCopper, Metal-binding, Metal-thiolate cluster

Enzyme and pathway databases

BioCyciYEAST:G3O-31107-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper metallothionein 1-1
Short name:
Cu-MT
Short name:
Cu-metallothionein
Alternative name(s):
Copper chelatin
Copper thionein
Gene namesi
Name:CUP1-1
Synonyms:MTH1
Ordered Locus Names:YHR053C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

SGDiS000001095. CUP1-1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000186751 – 88
ChainiPRO_00000186769 – 61Copper metallothionein 1-1Add BLAST53

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki30Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP0CX80.
PRIDEiP0CX80.

Interactioni

Protein-protein interaction databases

BioGridi36485. 6 interactors.
36487. 54 interactors.
MINTiMINT-555823.
STRINGi4932.YHR055C.

Structurei

Secondary structure

161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni20 – 24Combined sources5
Helixi26 – 28Combined sources3
Turni36 – 39Combined sources4
Helixi41 – 43Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AOONMR-A9-48[»]
1AQQNMR-A9-48[»]
1AQRNMR-A9-48[»]
1AQSNMR-A9-61[»]
1FMYNMR-A9-48[»]
1RJUX-ray1.44V13-48[»]
ProteinModelPortaliP0CX80.
SMRiP0CX80.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CX80.

Family & Domainsi

Domaini

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG092C5V5Y.

Family and domain databases

Gene3Di4.10.650.10. 1 hit.
InterProiView protein in InterPro
IPR017854. Metalthion_dom.
IPR022710. Metalthion_dom_yeast.
PfamiView protein in Pfam
PF11403. Yeast_MT. 1 hit.
SUPFAMiSSF57868. SSF57868. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CX80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSELINFQN EGHECQCQCG SCKNNEQCQK SCSCPTGCNS DDKCPCGNKS
60
EETKKSCCSG K
Length:61
Mass (Da):6,650
Last modified:June 28, 2011 - v1
Checksum:i688B0FF1DB986C6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02204 Genomic DNA. Translation: AAA34541.1.
U00061 Genomic DNA. Translation: AAB68382.1.
AY558517 Genomic DNA. Translation: AAS56843.1.
BK006934 Genomic DNA. Translation: DAA06748.1.
PIRiS14049.
RefSeqiNP_011920.1. NM_001179183.1.
NP_011922.1. NM_001179185.1.

Genome annotation databases

EnsemblFungiiYHR053C; YHR053C; YHR053C.
YHR055C; YHR055C; YHR055C.
GeneIDi856450.
856452.
KEGGisce:YHR053C.
sce:YHR055C.

Similar proteinsi

Entry informationi

Entry nameiMTCU1_YEAST
AccessioniPrimary (citable) accession number: P0CX80
Secondary accession number(s): D3DL02, P07215
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: July 5, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names