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Protein

Transposon Ty1-DR6 Gag polyprotein

Gene

TY1A-DR6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).By similarity

Miscellaneous

Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).

GO - Molecular functioni

  • RNA binding Source: SGD

GO - Biological processi

  • transposition, RNA-mediated Source: SGD

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transposon Ty1-DR6 Gag polyprotein
Alternative name(s):
Gag-p49
Transposon Ty1 protein A
Short name:
TY1A
Short name:
TYA
p58
Cleaved into the following 2 chains:
Capsid protein
Short name:
CA
Alternative name(s):
Gag-p45
p54
Gene namesi
Name:TY1A-DR6
Synonyms:YDRWTy1-5 GAG
Ordered Locus Names:YDR365W-A
ORF Names:D9481.12
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

SGDiS000007400 YDR365W-A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002790371 – 440Transposon Ty1-DR6 Gag polyproteinAdd BLAST440
ChainiPRO_00002790381 – 401Capsid proteinBy similarityAdd BLAST401
PeptideiPRO_0000279039402 – 440Gag-p4By similarityAdd BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei416PhosphoserineBy similarity1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei401 – 402Cleavage; by Ty1 proteaseBy similarity2

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0CX70
PRIDEiP0CX70
TopDownProteomicsiP0CX70-1 [P0CX70-1]

Expressioni

Inductioni

Ty1-DR6 is a highly expressed element. Induced under amino acid starvation conditions by GCN4.1 Publication

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi31430, 5 interactors
32423, 5 interactors
35904, 19 interactors
36886, 6 interactors
STRINGi4932.YPL257W-A

Structurei

3D structure databases

ProteinModelPortaliP0CX70
SMRiP0CX70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni299 – 401RNA-bindingBy similarityAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi64 – 146Pro-richAdd BLAST83

Domaini

The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities.By similarity

Phylogenomic databases

HOGENOMiHOG000000740
OrthoDBiEOG092C24YV

Family and domain databases

InterProiView protein in InterPro
IPR015820 Retrotransposon_Ty1A_N
PfamiView protein in Pfam
PF01021 TYA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by ribosomal frameshifting. AlignAdd to basket

Note: The Gag-Pol polyprotein is generated by a +1 ribosomal frameshift. The ratio of Gag:Gag-Pol varies between 20:1 and 5:1 (By similarity).By similarity
Isoform Transposon Ty1-DR6 Gag polyprotein (identifier: P0CX70-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESQQLSQHS PISHGSACAS VTSKEVHTNQ DPLDVSASKT EECEKASTKA
60 70 80 90 100
NSQQTTTPAS SAVPENPHHA SPQPASVPPP QNGPYPQQCM MTQNQANPSG
110 120 130 140 150
WSFYGHPSMI PYTPYQMSPM YFPPGPQSQF PQYPSSVGTP LSTPSPESGN
160 170 180 190 200
TFTDSSSADS DMTSTKKYVR PPPMLTSPND FPNWVKTYIK FLQNSNLGGI
210 220 230 240 250
IPTVNGKPVR QITDDELTFL YNTFQIFAPS QFLPTWVKDI LSVDYTDIMK
260 270 280 290 300
ILSKSIEKMQ SDTQEANDIV TLANLQYNGS TPADAFETKV TNIIDRLNNN
310 320 330 340 350
GIHINNKVAC QLIMRGLSGE YKFLRYTRHR HLNMTVAELF LDIHAIYEEQ
360 370 380 390 400
QGSRNSKPNY RRNLSDEKND SRSYTNTTKP KVIARNPQKT NNSKSKTARA
410 420 430 440
HNVSTSNNSP STDNDSISKS TTEPIQLNNK HDLHLRPGTY
Note: Produced by conventional translation.
Length:440
Mass (Da):48,953
Last modified:June 28, 2011 - v1
Checksum:iB3C484A9901A8296
GO
Isoform Transposon Ty1-DR6 Gag-Pol polyprotein (identifier: P0C2I3-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0C2I3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by +1 ribosomal frameshifting between codon Leu-435 and Gly-436 of the YDR365W-A ORF.
Length:1,755
Mass (Da):198,659
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28373 Genomic DNA No translation available.
BK006938 Genomic DNA Translation: DAA12206.1
PIRiS53553
RefSeqiNP_058153.3, NM_001184426.3 [P0CX70-1]
NP_058155.1, NM_001184428.1 [P0CX70-1]
NP_058170.1, NM_001184405.1 [P0CX70-1]
NP_058190.1, NM_001184391.1 [P0CX70-1]

Genome annotation databases

EnsemblFungiiYDR365W-A; YDR365W-A; YDR365W-A [P0CX70-1]
YER137C-A; YER137C-A; YER137C-A [P0CX70-1]
YLR157C-A; YLR157C-A; YLR157C-A [P0CX70-1]
YPL257W-A; YPL257W-A; YPL257W-A [P0CX70-1]
GeneIDi850854
851970
855816
856880
KEGGisce:YDR365W-A
sce:YER137C-A
sce:YLR157C-A
sce:YPL257W-A

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Similar proteinsi

Entry informationi

Entry nameiYD15A_YEAST
AccessioniPrimary (citable) accession number: P0CX70
Secondary accession number(s): D3DM44, Q12162
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome, Transposable element

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