Transposon Ty1-A Gag polyprotein - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P0CX57 (YA11A_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 13. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Transposon Ty1-A Gag polyprotein

Alternative name(s):
Gag-p49
Transposon Ty1 protein A
Short name=TY1A
Short name=TYA
p58

Cleaved into the following 2 chains:

Capsid protein
Short name=CA
Alternative name(s):
Gag-p45
p54
Gag-p4

Gene names

Name:	TY1A-A
Synonyms:	YARCTy1-1 GAG
Ordered Locus Names:	YAR010C
ORF Names:	P9659.6d

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription By similarity.
Subunit structure	Homotrimer By similarity.
Subcellular location	Cytoplasm By similarity.
Induction	Ty1-A is a weakly expressed element. Induced under amino acid starvation conditions by GCN4. Ref.5
Domain	The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities By similarity.
Miscellaneous	Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).
Caution	Transposon Ty1-A (YARCTy1-1) contains a frameshift at position 610, which disrupts the ORF coding for protein TY1B.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Ribosomal frameshifting
Ligand	RNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome Transposable element
Gene Ontology (GO)
Biological_process	transposition, RNA-mediated Inferred from sequence or structural similarity Ref.4. Source: SGD
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell retrotransposon nucleocapsid Inferred from sequence or structural similarity Ref.4. Source: SGD
Molecular_function	RNA binding Inferred from sequence or structural similarity Ref.4. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 440

440

Transposon Ty1-A Gag polyprotein

PRO_0000278982

Chain

1 – 401

401

Capsid protein By similarity

PRO_0000278983

Peptide

402 – 440

Gag-p4 By similarity

PRO_0000278984

Regions

Region

299 – 401

103

RNA-binding By similarity

Sites

Site

401 – 402

Cleavage; by Ty1 protease By similarity

Amino acid modifications

Modified residue

Phosphoserine Ref.9

Modified residue

Phosphoserine Ref.9

Modified residue

Phosphoserine Ref.9

Modified residue

Phosphothreonine Ref.9

Modified residue

Phosphoserine Ref.9

Modified residue

Phosphothreonine Ref.9

Modified residue

Phosphoserine Ref.9

Modified residue

Phosphoserine Ref.9

Modified residue

Phosphoserine Ref.9

Modified residue

145

Phosphoserine Ref.9

Modified residue

160

Phosphoserine Ref.9

Modified residue

177

Phosphoserine Ref.7

Modified residue

280

Phosphoserine Ref.9

Modified residue

353

Phosphoserine Ref.9

Modified residue

371

Phosphoserine Ref.9

Modified residue

373

Phosphoserine Ref.9

Modified residue

375

Phosphothreonine Ref.9

Modified residue

405

Phosphothreonine Ref.9

Modified residue

406

Phosphoserine Ref.9

Modified residue

409

Phosphoserine Ref.7 Ref.9

Modified residue

411

Phosphoserine Ref.7

Modified residue

412

Phosphothreonine Ref.8

Modified residue

416

Phosphoserine Ref.8 Ref.9

Modified residue

418

Phosphoserine Ref.9

Modified residue

421

Phosphothreonine Ref.9

Modified residue

422

Phosphothreonine Ref.9

Sequences

Sequence

Length

Mass (Da)

Tools

P0CX57 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: DCE9E5C434D51201
Show »

FASTA

440

49,072

        10         20         30         40         50         60 
MESQQLSQHS PISHGSACAS VTSKEVHTNQ DPLDVSASKT EECEKASTKA NSQQTTTPAS 

        70         80         90        100        110        120 
SAVPENPHHA SPQTAQSHSP QNGPYPQQCM MTQNQANPSG WSFYGHPSMI PYTPYQMSPM 

       130        140        150        160        170        180 
YFPPGPQSQF PQYPSSVGTP LSTPSPESGN TFTDSSSADS DMTSTKKYVR PPPMLTSPND 

       190        200        210        220        230        240 
FPNWVKTYIK FLQNSNLGGI IPTVNGKPVR QITDDELTFL YNTFQIFAPS QFLPTWVKDI 

       250        260        270        280        290        300 
LSVDYTDIMK ILSKSIEKMQ SDTQEANDIV TLANLQYNGS TPADAFETKV TNIIDRLNNN 

       310        320        330        340        350        360 
GIHINNKVAC QLIMRGLSGE YKFLRYTRHR HLNMTVAELF LDIHAIYEEQ QGSRNSKPNY 

       370        380        390        400        410        420 
RRNPSDEKND SRSYTNTTKP KVIARNPQKT NNSKSKTARA HNVSTSNNSP STDNDSISKS 

       430        440 
TTEPIQLNNK HDLHLRPETY

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region." Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H. Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K. Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Transposable elements and genome organization: a comprehensive survey of retrotransposons revealed by the complete Saccharomyces cerevisiae genome sequence." Kim J.M., Vanguri S., Boeke J.D., Gabriel A., Voytas D.F. Genome Res. 8:464-478(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.
[5]	"Differential effects of chromatin and Gcn4 on the 50-fold range of expression among individual yeast Ty1 retrotransposons." Morillon A., Benard L., Springer M., Lesage P. Mol. Cell. Biol. 22:2078-2088(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[6]	"Happy together: the life and times of Ty retrotransposons and their hosts." Lesage P., Todeschini A.L. Cytogenet. Genome Res. 110:70-90(2005) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[7]	"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P. J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-177; SER-409 AND SER-411, MASS SPECTROMETRY. Strain: ADR376.
[8]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-412 AND SER-416, MASS SPECTROMETRY.
[9]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-16; SER-20; THR-22; SER-23; THR-28; SER-36; SER-71; SER-79; SER-145; SER-160; SER-280; SER-353; SER-371; SER-373; THR-375; THR-405; SER-406; SER-409; SER-416; SER-418; THR-421 AND THR-422, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L22015 Genomic DNA. Translation: AAC04966.1. BK006935 Genomic DNA. Translation: DAA06992.1.
PIR	S40909.
RefSeq	NP_009407.1. NM_001178214.1. NP_058192.1. NM_001184393.1.
3D structure databases
ProteinModelPortal	P0CX57.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YAR010C; YAR010C; YAR010C. YPR137C-A; YPR137C-A; YPR137C-A.
GeneID	851269. 856258.
KEGG	sce:YAR010C. sce:YPR137C-A.
Organism-specific databases
CYGD	YAR010c.
SGD	S000000068. YAR010C.
Phylogenomic databases
HOGENOM	HOG000000740.
Gene expression databases
ArrayExpress	P0CX57.
Family and domain databases
InterPro	IPR015820. Retrotransposon_Ty1A_N. [Graphical view]
Pfam	PF01021. TYA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	968243.

Entry information

Entry name

YA11A_YEAST

Accession

Primary (citable) accession number: P0CX57
Secondary accession number(s): D6VPM2, O13528

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 28, 2011
Last sequence update:	June 28, 2011
Last modified:	April 3, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Cleaved into the following 2 chains:

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents