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P0CX55

- RS18A_YEAST

UniProt

P0CX55 - RS18A_YEAST

Protein

40S ribosomal protein S18-A

Gene

RPS18A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.By similarity

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-KW
    2. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD
    2. endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    3. rRNA export from nucleus Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29981-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S18-A
    Gene namesi
    Name:RPS18A
    Ordered Locus Names:YDR450W
    ORF Names:D9461.35
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    SGDiS000002858. RPS18A.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosolic small ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 14614540S ribosomal protein S18-APRO_0000132227Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine3 Publications

    Post-translational modificationi

    N-terminally acetylated by acetyltransferase NatA.3 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP0CX55.

    Interactioni

    Subunit structurei

    Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi32505. 74 interactions.
    35143. 66 interactions.
    IntActiP0CX55. 1 interaction.
    MINTiMINT-572872.

    Structurei

    Secondary structure

    1
    146
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi13 – 153
    Beta strandi20 – 223
    Beta strandi24 – 263
    Turni28 – 314
    Helixi32 – 343
    Helixi40 – 5011
    Beta strandi58 – 603
    Helixi63 – 7311
    Turni76 – 805
    Helixi83 – 853
    Beta strandi92 – 943
    Helixi103 – 11816
    Helixi122 – 1287
    Beta strandi133 – 1353
    Beta strandi139 – 1413

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K5Xmodel-M15-145[»]
    1S1Helectron microscopy11.70M15-146[»]
    1VW9electron microscopy6.10T1-146[»]
    1VWVelectron microscopy6.10T1-146[»]
    3IZBelectron microscopy-M1-146[»]
    3O2ZX-ray4.00L1-146[»]
    3O30X-ray4.00L1-146[»]
    3U5CX-ray3.00S1-146[»]
    3U5GX-ray3.00S1-146[»]
    4BYLelectron microscopy4.30S1-146[»]
    4BYTelectron microscopy6.60S1-146[»]
    4CUYelectron microscopy3.70S2-141[»]
    ProteinModelPortaliP0CX55.
    SMRiP0CX55. Positions 2-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0CX55.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S13P family.Curated

    Phylogenomic databases

    KOiK02964.
    OrthoDBiEOG7966V3.

    Family and domain databases

    Gene3Di4.10.910.10. 1 hit.
    HAMAPiMF_01315. Ribosomal_S13_S18.
    InterProiIPR027437. 30s_Rbsml_prot_S13_C.
    IPR001892. Ribosomal_S13.
    IPR010979. Ribosomal_S13-like_H2TH.
    IPR018269. Ribosomal_S13_CS.
    [Graphical view]
    PfamiPF00416. Ribosomal_S13. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002134. Ribosomal_S13. 1 hit.
    SUPFAMiSSF46946. SSF46946. 1 hit.
    PROSITEiPS00646. RIBOSOMAL_S13_1. 1 hit.
    PS50159. RIBOSOMAL_S13_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0CX55-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLVVQEQGS FQHILRLLNT NVDGNIKIVY ALTTIKGVGR RYSNLVCKKA    50
    DVDLHKRAGE LTQEELERIV QIMQNPTHYK IPAWFLNRQN DITDGKDYHT 100
    LANNVESKLR DDLERLKKIR AHRGIRHFWG LRVRGQHTKT TGRRRA 146
    Length:146
    Mass (Da):17,038
    Last modified:June 28, 2011 - v1
    Checksum:i1F50BF9ADD20CA19
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33007 Genomic DNA. Translation: AAB64891.1.
    BK006938 Genomic DNA. Translation: DAA12285.1.
    PIRiS50886.
    RefSeqiNP_010738.1. NM_001180758.1.
    NP_013686.1. NM_001182384.1.

    Genome annotation databases

    EnsemblFungiiYDR450W; YDR450W; YDR450W.
    YML026C; YML026C; YML026C.
    GeneIDi852061.
    854982.
    KEGGisce:YDR450W.
    sce:YML026C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33007 Genomic DNA. Translation: AAB64891.1 .
    BK006938 Genomic DNA. Translation: DAA12285.1 .
    PIRi S50886.
    RefSeqi NP_010738.1. NM_001180758.1.
    NP_013686.1. NM_001182384.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K5X model - M 15-145 [» ]
    1S1H electron microscopy 11.70 M 15-146 [» ]
    1VW9 electron microscopy 6.10 T 1-146 [» ]
    1VWV electron microscopy 6.10 T 1-146 [» ]
    3IZB electron microscopy - M 1-146 [» ]
    3O2Z X-ray 4.00 L 1-146 [» ]
    3O30 X-ray 4.00 L 1-146 [» ]
    3U5C X-ray 3.00 S 1-146 [» ]
    3U5G X-ray 3.00 S 1-146 [» ]
    4BYL electron microscopy 4.30 S 1-146 [» ]
    4BYT electron microscopy 6.60 S 1-146 [» ]
    4CUY electron microscopy 3.70 S 2-141 [» ]
    ProteinModelPortali P0CX55.
    SMRi P0CX55. Positions 2-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32505. 74 interactions.
    35143. 66 interactions.
    IntActi P0CX55. 1 interaction.
    MINTi MINT-572872.

    Proteomic databases

    MaxQBi P0CX55.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDR450W ; YDR450W ; YDR450W .
    YML026C ; YML026C ; YML026C .
    GeneIDi 852061.
    854982.
    KEGGi sce:YDR450W.
    sce:YML026C.

    Organism-specific databases

    SGDi S000002858. RPS18A.

    Phylogenomic databases

    KOi K02964.
    OrthoDBi EOG7966V3.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29981-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    EvolutionaryTracei P0CX55.
    NextBioi 970337.

    Family and domain databases

    Gene3Di 4.10.910.10. 1 hit.
    HAMAPi MF_01315. Ribosomal_S13_S18.
    InterProi IPR027437. 30s_Rbsml_prot_S13_C.
    IPR001892. Ribosomal_S13.
    IPR010979. Ribosomal_S13-like_H2TH.
    IPR018269. Ribosomal_S13_CS.
    [Graphical view ]
    Pfami PF00416. Ribosomal_S13. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002134. Ribosomal_S13. 1 hit.
    SUPFAMi SSF46946. SSF46946. 1 hit.
    PROSITEi PS00646. RIBOSOMAL_S13_1. 1 hit.
    PS50159. RIBOSOMAL_S13_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Bienvenut W.V., Peters C.
      Submitted (MAY-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-36; 58-68 AND 81-88, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
    4. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    5. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2 BY NATA.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
      Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
      Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 15-145, ELECTRON MICROSCOPY.
    11. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
      Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
      EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 15-146, ELECTRON MICROSCOPY.

    Entry informationi

    Entry nameiRS18A_YEAST
    AccessioniPrimary (citable) accession number: P0CX55
    Secondary accession number(s): D6VT75, P35271
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 48100 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for S18 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3