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P0CX51

- RS16A_YEAST

UniProt

P0CX51 - RS16A_YEAST

Protein

40S ribosomal protein S16-A

Gene

RPS16A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD
    2. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32835-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S16-A
    Alternative name(s):
    RP61R
    Gene namesi
    Name:RPS16A
    Synonyms:RP61R
    Ordered Locus Names:YMR143W
    ORF Names:YM9375.12
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    SGDiS000004751. RPS16A.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosolic small ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 14314240S ribosomal protein S16-APRO_0000111503Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications
    Modified residuei34 – 341Phosphoserine2 Publications
    Modified residuei61 – 611Phosphoserine1 Publication
    Modified residuei70 – 701Phosphothreonine1 Publication
    Modified residuei76 – 761Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP0CX51.

    Interactioni

    Subunit structurei

    Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi31978. 150 interactions.
    35319. 88 interactions.
    IntActiP0CX51. 2 interactions.
    MINTiMINT-8285666.

    Structurei

    Secondary structure

    1
    143
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 116
    Beta strandi17 – 248
    Beta strandi29 – 313
    Turni36 – 383
    Helixi45 – 5410
    Helixi57 – 604
    Beta strandi63 – 7210
    Helixi74 – 9522
    Helixi99 – 11214
    Beta strandi129 – 1357

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K5Xmodel-I5-143[»]
    1S1Helectron microscopy11.70I2-143[»]
    1VW9electron microscopy6.10R1-143[»]
    1VWVelectron microscopy6.10R1-143[»]
    3IZBelectron microscopy-I1-143[»]
    3O2ZX-ray4.00J1-143[»]
    3O30X-ray4.00J1-143[»]
    3U5CX-ray3.00Q1-143[»]
    3U5GX-ray3.00Q1-143[»]
    4BYLelectron microscopy4.30Q1-143[»]
    4BYTelectron microscopy6.60Q1-143[»]
    4CUYelectron microscopy3.70Q3-142[»]
    ProteinModelPortaliP0CX51.
    SMRiP0CX51. Positions 2-143.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0CX51.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S9P family.Curated

    Phylogenomic databases

    KOiK02960.
    OrthoDBiEOG7ZPNXQ.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR000754. Ribosomal_S9.
    IPR020574. Ribosomal_S9_CS.
    [Graphical view]
    PANTHERiPTHR21569. PTHR21569. 1 hit.
    PfamiPF00380. Ribosomal_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF54211. SSF54211. 1 hit.
    PROSITEiPS00360. RIBOSOMAL_S9. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0CX51-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAVPSVQTF GKKKSATAVA HVKAGKGLIK VNGSPITLVE PEILRFKVYE    50
    PLLLVGLDKF SNIDIRVRVT GGGHVSQVYA IRQAIAKGLV AYHQKYVDEQ 100
    SKNELKKAFT SYDRTLLIAD SRRPEPKKFG GKGARSRFQK SYR 143
    Length:143
    Mass (Da):15,847
    Last modified:June 28, 2011 - v1
    Checksum:i46360374CD9730CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z47071 Genomic DNA. Translation: CAA87357.1.
    BK006946 Genomic DNA. Translation: DAA10039.1.
    PIRiS67619.
    RefSeqiNP_010200.1. NM_001180142.1.
    NP_013863.2. NM_001182645.1.

    Genome annotation databases

    EnsemblFungiiYDL083C; YDL083C; YDL083C.
    YMR143W; YMR143W; YMR143W.
    GeneIDi851476.
    855174.
    KEGGisce:YDL083C.
    sce:YMR143W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z47071 Genomic DNA. Translation: CAA87357.1 .
    BK006946 Genomic DNA. Translation: DAA10039.1 .
    PIRi S67619.
    RefSeqi NP_010200.1. NM_001180142.1.
    NP_013863.2. NM_001182645.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K5X model - I 5-143 [» ]
    1S1H electron microscopy 11.70 I 2-143 [» ]
    1VW9 electron microscopy 6.10 R 1-143 [» ]
    1VWV electron microscopy 6.10 R 1-143 [» ]
    3IZB electron microscopy - I 1-143 [» ]
    3O2Z X-ray 4.00 J 1-143 [» ]
    3O30 X-ray 4.00 J 1-143 [» ]
    3U5C X-ray 3.00 Q 1-143 [» ]
    3U5G X-ray 3.00 Q 1-143 [» ]
    4BYL electron microscopy 4.30 Q 1-143 [» ]
    4BYT electron microscopy 6.60 Q 1-143 [» ]
    4CUY electron microscopy 3.70 Q 3-142 [» ]
    ProteinModelPortali P0CX51.
    SMRi P0CX51. Positions 2-143.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31978. 150 interactions.
    35319. 88 interactions.
    IntActi P0CX51. 2 interactions.
    MINTi MINT-8285666.

    Proteomic databases

    MaxQBi P0CX51.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDL083C ; YDL083C ; YDL083C .
    YMR143W ; YMR143W ; YMR143W .
    GeneIDi 851476.
    855174.
    KEGGi sce:YDL083C.
    sce:YMR143W.

    Organism-specific databases

    SGDi S000004751. RPS16A.

    Phylogenomic databases

    KOi K02960.
    OrthoDBi EOG7ZPNXQ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32835-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    EvolutionaryTracei P0CX51.
    NextBioi 968780.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    InterProi IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR000754. Ribosomal_S9.
    IPR020574. Ribosomal_S9_CS.
    [Graphical view ]
    PANTHERi PTHR21569. PTHR21569. 1 hit.
    Pfami PF00380. Ribosomal_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54211. SSF54211. 1 hit.
    PROSITEi PS00360. RIBOSOMAL_S9. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "NH2-terminal acetylation of ribosomal proteins of Saccharomyces cerevisiae."
      Takakura H., Tsunasawa S., Miyagi M., Warner J.R.
      J. Biol. Chem. 267:5442-5445(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY PROTEIN SEQUENCE OF 2-26, ACETYLATION AT SER-2 BY NATA.
    4. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    5. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2 BY NATA.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61; THR-70 AND SER-76, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
      Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
      Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 5-143, ELECTRON MICROSCOPY.
    13. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
      Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
      EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.

    Entry informationi

    Entry nameiRS16A_YEAST
    AccessioniPrimary (citable) accession number: P0CX51
    Secondary accession number(s): D6VRR6, P26787, P40213
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 33800 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for S16 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3