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P0CX48

- RS11B_YEAST

UniProt

P0CX48 - RS11B_YEAST

Protein

40S ribosomal protein S11-B

Gene

RPS11B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-KW
    2. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD
    2. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    3. ribosomal small subunit assembly Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29020-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S11-B
    Alternative name(s):
    RP41
    S18
    YS12
    Gene namesi
    Name:RPS11B
    Synonyms:RPS18B
    Ordered Locus Names:YBR048W
    ORF Names:YBR0501
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR048w.
    SGDiS000000252. RPS11B.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosolic small ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 15615540S ribosomal protein S11-BPRO_0000409770Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications

    Post-translational modificationi

    N-terminally acetylated by acetyltransferase NatA.2 Publications

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi32075. 120 interactions.
    32750. 149 interactions.
    IntActiP0CX48. 1 interaction.
    MINTiMINT-519673.

    Structurei

    3D structure databases

    ProteinModelPortaliP0CX48.
    SMRiP0CX48. Positions 2-156.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S17P family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00390000002732.
    KOiK02949.
    OrthoDBiEOG7MD52Z.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_01345_B. Ribosomal_S17_B.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR000266. Ribosomal_S17.
    IPR028333. Ribosomal_S17_arc-typ.
    IPR019979. Ribosomal_S17_CS.
    [Graphical view]
    PANTHERiPTHR10744. PTHR10744. 1 hit.
    PfamiPF00366. Ribosomal_S17. 1 hit.
    [Graphical view]
    PRINTSiPR00973. RIBOSOMALS17.
    ProDomiPD001295. Ribosomal_S17. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR03630. arch_S17P. 1 hit.
    PROSITEiPS00056. RIBOSOMAL_S17. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0CX48-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTELTVQSE RAFQKQPHIF NNPKVKTSKR TKRWYKNAGL GFKTPKTAIE    50
    GSYIDKKCPF TGLVSIRGKI LTGTVVSTKM HRTIVIRRAY LHYIPKYNRY 100
    EKRHKNVPVH VSPAFRVQVG DIVTVGQCRP ISKTVRFNVV KVSAAAGKAN 150
    KQFAKF 156
    Length:156
    Mass (Da):17,749
    Last modified:June 28, 2011 - v1
    Checksum:i6F7825FAE17EB084
    GO

    Sequence cautioni

    The sequence CAA86390.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 132AF → FA AA sequence (PubMed:1544921)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L17004 Unassigned DNA. Translation: AAC37410.1.
    Z46260 Genomic DNA. Translation: CAA86390.1. Sequence problems.
    Z35917 Genomic DNA. Translation: CAA84990.1.
    Z35918 Genomic DNA. Translation: CAA84991.1.
    BK006936 Genomic DNA. Translation: DAA07168.1.
    PIRiS41784.
    RefSeqiNP_009604.1. NM_001178396.1.
    NP_010308.3. NM_001180333.3.

    Genome annotation databases

    EnsemblFungiiYBR048W; YBR048W; YBR048W.
    YDR025W; YDR025W; YDR025W.
    GeneIDi851589.
    852337.
    KEGGisce:YBR048W.
    sce:YDR025W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L17004 Unassigned DNA. Translation: AAC37410.1 .
    Z46260 Genomic DNA. Translation: CAA86390.1 . Sequence problems.
    Z35917 Genomic DNA. Translation: CAA84990.1 .
    Z35918 Genomic DNA. Translation: CAA84991.1 .
    BK006936 Genomic DNA. Translation: DAA07168.1 .
    PIRi S41784.
    RefSeqi NP_009604.1. NM_001178396.1.
    NP_010308.3. NM_001180333.3.

    3D structure databases

    ProteinModelPortali P0CX48.
    SMRi P0CX48. Positions 2-156.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32075. 120 interactions.
    32750. 149 interactions.
    IntActi P0CX48. 1 interaction.
    MINTi MINT-519673.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR048W ; YBR048W ; YBR048W .
    YDR025W ; YDR025W ; YDR025W .
    GeneIDi 851589.
    852337.
    KEGGi sce:YBR048W.
    sce:YDR025W.

    Organism-specific databases

    CYGDi YBR048w.
    SGDi S000000252. RPS11B.

    Phylogenomic databases

    GeneTreei ENSGT00390000002732.
    KOi K02949.
    OrthoDBi EOG7MD52Z.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29020-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    NextBioi 969066.
    PROi P0CX48.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_01345_B. Ribosomal_S17_B.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR000266. Ribosomal_S17.
    IPR028333. Ribosomal_S17_arc-typ.
    IPR019979. Ribosomal_S17_CS.
    [Graphical view ]
    PANTHERi PTHR10744. PTHR10744. 1 hit.
    Pfami PF00366. Ribosomal_S17. 1 hit.
    [Graphical view ]
    PRINTSi PR00973. RIBOSOMALS17.
    ProDomi PD001295. Ribosomal_S17. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR03630. arch_S17P. 1 hit.
    PROSITEi PS00056. RIBOSOMAL_S17. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Reduced dosage of genes encoding ribosomal protein S18 suppresses a mitochondrial initiation codon mutation in Saccharomyces cerevisiae."
      Folley L.S., Fox T.D.
      Genetics 137:369-379(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Sequence and analysis of 24 kb on chromosome II of Saccharomyces cerevisiae."
      Aljinovic G., Pohl T.M.
      Yeast 11:475-479(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "NH2-terminal acetylation of ribosomal proteins of Saccharomyces cerevisiae."
      Takakura H., Tsunasawa S., Miyagi M., Warner J.R.
      J. Biol. Chem. 267:5442-5445(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-21, ACETYLATION AT SER-2 BY NATA.
    6. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRS11B_YEAST
    AccessioniPrimary (citable) accession number: P0CX48
    Secondary accession number(s): D6VQ48, O11852, P26781
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1200 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for S11 in yeast.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Ribosomal proteins
      Ribosomal proteins families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3