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Protein

40S ribosomal protein S11-A

Gene

RPS11A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-KW
  2. structural constituent of ribosome Source: SGD

GO - Biological processi

  1. cytoplasmic translation Source: SGD
  2. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  3. ribosomal small subunit assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29641-MONOMER.
ReactomeiREACT_290856. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_302067. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_307259. Formation of a pool of free 40S subunits.
REACT_314339. SRP-dependent cotranslational protein targeting to membrane.
REACT_332565. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_335938. Ribosomal scanning and start codon recognition.
REACT_343353. Peptide chain elongation.
REACT_346847. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_351622. Formation of the ternary complex, and subsequently, the 43S complex.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S11-A
Alternative name(s):
RP41
S18
YS12
Gene namesi
Name:RPS11A
Synonyms:RPS18A
Ordered Locus Names:YDR025W
ORF Names:YD9813.03
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome IV

Organism-specific databases

CYGDiYDR025w.
SGDiS000002432. RPS11A.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosolic small ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 15615540S ribosomal protein S11-APRO_0000128523Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine3 Publications

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP0CX47.

Expressioni

Gene expression databases

ExpressionAtlasiP0CX47. differential.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi32075. 122 interactions.
32750. 150 interactions.
IntActiP0CX47. 1 interaction.
MINTiMINT-8285636.

Structurei

Secondary structure

1
156
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 123Combined sources
Beta strandi23 – 253Combined sources
Beta strandi28 – 314Combined sources
Helixi46 – 494Combined sources
Turni59 – 613Combined sources
Beta strandi70 – 778Combined sources
Beta strandi83 – 9412Combined sources
Turni95 – 984Combined sources
Beta strandi99 – 11012Combined sources
Beta strandi122 – 1276Combined sources
Beta strandi132 – 1343Combined sources
Beta strandi137 – 1437Combined sources
Beta strandi145 – 1484Combined sources
Helixi150 – 1523Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Xmodel-Q69-144[»]
3J6Xelectron microscopy6.10111-156[»]
3J6Yelectron microscopy6.10111-156[»]
3J77electron microscopy6.20111-156[»]
3J78electron microscopy6.30111-156[»]
3V88X-ray3.00L1-156[»]
4U3MX-ray3.00C1/c12-156[»]
4U3NX-ray3.20C1/c12-156[»]
4U3UX-ray2.90C1/c12-156[»]
4U4NX-ray3.10C1/c12-156[»]
4U4OX-ray3.60C1/c12-156[»]
4U4QX-ray3.00C1/c12-156[»]
4U4RX-ray2.80C1/c12-156[»]
4U4UX-ray3.00C1/c12-156[»]
4U4YX-ray3.20C1/c12-156[»]
4U4ZX-ray3.10C1/c12-156[»]
4U50X-ray3.20C1/c12-156[»]
4U51X-ray3.20C1/c12-156[»]
4U52X-ray3.00C1/c12-156[»]
4U53X-ray3.30C1/c12-156[»]
4U55X-ray3.20C1/c12-156[»]
4U56X-ray3.45C1/c12-156[»]
4U6FX-ray3.10C1/c12-156[»]
4V4Belectron microscopy11.70AQ69-144[»]
4V6Ielectron microscopy8.80AP1-156[»]
4V7RX-ray4.00AF/CF1-156[»]
4V88X-ray3.00AL/CL1-156[»]
4V8Yelectron microscopy4.30AL1-156[»]
4V8Zelectron microscopy6.60AL1-156[»]
4V92electron microscopy3.70L4-145[»]
ProteinModelPortaliP0CX47.
SMRiP0CX47. Positions 2-156.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CX47.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S17P family.Curated

Phylogenomic databases

InParanoidiP0CX47.
KOiK02949.
OrthoDBiEOG7MD52Z.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_01345_B. Ribosomal_S17_B.
InterProiIPR012340. NA-bd_OB-fold.
IPR000266. Ribosomal_S17.
IPR028333. Ribosomal_S17_arc-typ.
IPR019979. Ribosomal_S17_CS.
[Graphical view]
PANTHERiPTHR10744. PTHR10744. 1 hit.
PfamiPF00366. Ribosomal_S17. 1 hit.
[Graphical view]
PRINTSiPR00973. RIBOSOMALS17.
ProDomiPD001295. Ribosomal_S17. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR03630. arch_S17P. 1 hit.
PROSITEiPS00056. RIBOSOMAL_S17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CX47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTELTVQSE RAFQKQPHIF NNPKVKTSKR TKRWYKNAGL GFKTPKTAIE
60 70 80 90 100
GSYIDKKCPF TGLVSIRGKI LTGTVVSTKM HRTIVIRRAY LHYIPKYNRY
110 120 130 140 150
EKRHKNVPVH VSPAFRVQVG DIVTVGQCRP ISKTVRFNVV KVSAAAGKAN

KQFAKF
Length:156
Mass (Da):17,749
Last modified:June 28, 2011 - v1
Checksum:i6F7825FAE17EB084
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 132AF → FA AA sequence (PubMed:1544921).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15408 Unassigned DNA. Translation: AAC37411.1.
X95966 Genomic DNA. Translation: CAA65218.1.
Z47814 Genomic DNA. Translation: CAA87804.1.
Z74321 Genomic DNA. Translation: CAA98846.1.
BK006938 Genomic DNA. Translation: DAA11870.1.
PIRiS41784.
RefSeqiNP_009604.1. NM_001178396.1.
NP_010308.3. NM_001180333.3.

Genome annotation databases

EnsemblFungiiYBR048W; YBR048W; YBR048W.
YDR025W; YDR025W; YDR025W.
GeneIDi851589.
852337.
KEGGisce:YBR048W.
sce:YDR025W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15408 Unassigned DNA. Translation: AAC37411.1.
X95966 Genomic DNA. Translation: CAA65218.1.
Z47814 Genomic DNA. Translation: CAA87804.1.
Z74321 Genomic DNA. Translation: CAA98846.1.
BK006938 Genomic DNA. Translation: DAA11870.1.
PIRiS41784.
RefSeqiNP_009604.1. NM_001178396.1.
NP_010308.3. NM_001180333.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Xmodel-Q69-144[»]
3J6Xelectron microscopy6.10111-156[»]
3J6Yelectron microscopy6.10111-156[»]
3J77electron microscopy6.20111-156[»]
3J78electron microscopy6.30111-156[»]
3V88X-ray3.00L1-156[»]
4U3MX-ray3.00C1/c12-156[»]
4U3NX-ray3.20C1/c12-156[»]
4U3UX-ray2.90C1/c12-156[»]
4U4NX-ray3.10C1/c12-156[»]
4U4OX-ray3.60C1/c12-156[»]
4U4QX-ray3.00C1/c12-156[»]
4U4RX-ray2.80C1/c12-156[»]
4U4UX-ray3.00C1/c12-156[»]
4U4YX-ray3.20C1/c12-156[»]
4U4ZX-ray3.10C1/c12-156[»]
4U50X-ray3.20C1/c12-156[»]
4U51X-ray3.20C1/c12-156[»]
4U52X-ray3.00C1/c12-156[»]
4U53X-ray3.30C1/c12-156[»]
4U55X-ray3.20C1/c12-156[»]
4U56X-ray3.45C1/c12-156[»]
4U6FX-ray3.10C1/c12-156[»]
4V4Belectron microscopy11.70AQ69-144[»]
4V6Ielectron microscopy8.80AP1-156[»]
4V7RX-ray4.00AF/CF1-156[»]
4V88X-ray3.00AL/CL1-156[»]
4V8Yelectron microscopy4.30AL1-156[»]
4V8Zelectron microscopy6.60AL1-156[»]
4V92electron microscopy3.70L4-145[»]
ProteinModelPortaliP0CX47.
SMRiP0CX47. Positions 2-156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32075. 122 interactions.
32750. 150 interactions.
IntActiP0CX47. 1 interaction.
MINTiMINT-8285636.

Proteomic databases

MaxQBiP0CX47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR048W; YBR048W; YBR048W.
YDR025W; YDR025W; YDR025W.
GeneIDi851589.
852337.
KEGGisce:YBR048W.
sce:YDR025W.

Organism-specific databases

CYGDiYDR025w.
SGDiS000002432. RPS11A.

Phylogenomic databases

InParanoidiP0CX47.
KOiK02949.
OrthoDBiEOG7MD52Z.

Enzyme and pathway databases

BioCyciYEAST:G3O-29641-MONOMER.
ReactomeiREACT_290856. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_302067. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_307259. Formation of a pool of free 40S subunits.
REACT_314339. SRP-dependent cotranslational protein targeting to membrane.
REACT_332565. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_335938. Ribosomal scanning and start codon recognition.
REACT_343353. Peptide chain elongation.
REACT_346847. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_351622. Formation of the ternary complex, and subsequently, the 43S complex.

Miscellaneous databases

EvolutionaryTraceiP0CX47.
NextBioi969066.

Gene expression databases

ExpressionAtlasiP0CX47. differential.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_01345_B. Ribosomal_S17_B.
InterProiIPR012340. NA-bd_OB-fold.
IPR000266. Ribosomal_S17.
IPR028333. Ribosomal_S17_arc-typ.
IPR019979. Ribosomal_S17_CS.
[Graphical view]
PANTHERiPTHR10744. PTHR10744. 1 hit.
PfamiPF00366. Ribosomal_S17. 1 hit.
[Graphical view]
PRINTSiPR00973. RIBOSOMALS17.
ProDomiPD001295. Ribosomal_S17. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR03630. arch_S17P. 1 hit.
PROSITEiPS00056. RIBOSOMAL_S17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Reduced dosage of genes encoding ribosomal protein S18 suppresses a mitochondrial initiation codon mutation in Saccharomyces cerevisiae."
    Folley L.S., Fox T.D.
    Genetics 137:369-379(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Sequencing and analysis of a 35.4 kb region on the right arm of chromosome IV from Saccharomyces cerevisiae reveal 23 open reading frames."
    Eide L.G., Sander C., Prydz H.
    Yeast 12:1085-1090(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "NH2-terminal acetylation of ribosomal proteins of Saccharomyces cerevisiae."
    Takakura H., Tsunasawa S., Miyagi M., Warner J.R.
    J. Biol. Chem. 267:5442-5445(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-21, ACETYLATION AT SER-2 BY NATA.
  6. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  7. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
    Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
    J. Biol. Chem. 274:37035-37040(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2 BY NATA.
  8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  10. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
    Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
    Cell 107:373-386(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 69-144, ELECTRON MICROSCOPY.
  12. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
    Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
    EMBO J. 23:1008-1019(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 69-144, ELECTRON MICROSCOPY.

Entry informationi

Entry nameiRS11A_YEAST
AccessioniPrimary (citable) accession number: P0CX47
Secondary accession number(s): D6VQ48, O11852, P26781
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: April 1, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 2 genes for S11 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.