Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0CX47

- RS11A_YEAST

UniProt

P0CX47 - RS11A_YEAST

Protein

40S ribosomal protein S11-A

Gene

RPS11A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-KW
    2. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD
    2. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    3. ribosomal small subunit assembly Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29641-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S11-A
    Alternative name(s):
    RP41
    S18
    YS12
    Gene namesi
    Name:RPS11A
    Synonyms:RPS18A
    Ordered Locus Names:YDR025W
    ORF Names:YD9813.03
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDR025w.
    SGDiS000002432. RPS11A.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosolic small ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 15615540S ribosomal protein S11-APRO_0000128523Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine3 Publications

    Post-translational modificationi

    N-terminally acetylated by acetyltransferase NatA.3 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP0CX47.

    Interactioni

    Subunit structurei

    Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi32075. 120 interactions.
    32750. 149 interactions.
    IntActiP0CX47. 1 interaction.
    MINTiMINT-8285636.

    Structurei

    Secondary structure

    1
    156
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi10 – 123
    Beta strandi23 – 253
    Beta strandi28 – 314
    Helixi46 – 505
    Turni59 – 613
    Beta strandi66 – 7712
    Beta strandi83 – 9412
    Turni95 – 984
    Beta strandi99 – 11012
    Beta strandi122 – 13211
    Beta strandi135 – 1428
    Beta strandi147 – 1493
    Helixi150 – 1523

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K5Xmodel-Q69-144[»]
    1S1Helectron microscopy11.70Q69-144[»]
    1VW9electron microscopy6.10M1-156[»]
    1VWVelectron microscopy6.10M1-156[»]
    3IZBelectron microscopy-P1-156[»]
    3O2ZX-ray4.00F1-156[»]
    3O30X-ray4.00F1-156[»]
    3U5CX-ray3.00L1-156[»]
    3U5GX-ray3.00L1-156[»]
    4BYLelectron microscopy4.30L1-156[»]
    4BYTelectron microscopy6.60L1-156[»]
    4CUYelectron microscopy3.70L4-145[»]
    ProteinModelPortaliP0CX47.
    SMRiP0CX47. Positions 2-156.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0CX47.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S17P family.Curated

    Phylogenomic databases

    KOiK02949.
    OrthoDBiEOG7MD52Z.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_01345_B. Ribosomal_S17_B.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR000266. Ribosomal_S17.
    IPR028333. Ribosomal_S17_arc-typ.
    IPR019979. Ribosomal_S17_CS.
    [Graphical view]
    PANTHERiPTHR10744. PTHR10744. 1 hit.
    PfamiPF00366. Ribosomal_S17. 1 hit.
    [Graphical view]
    PRINTSiPR00973. RIBOSOMALS17.
    ProDomiPD001295. Ribosomal_S17. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR03630. arch_S17P. 1 hit.
    PROSITEiPS00056. RIBOSOMAL_S17. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0CX47-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTELTVQSE RAFQKQPHIF NNPKVKTSKR TKRWYKNAGL GFKTPKTAIE    50
    GSYIDKKCPF TGLVSIRGKI LTGTVVSTKM HRTIVIRRAY LHYIPKYNRY 100
    EKRHKNVPVH VSPAFRVQVG DIVTVGQCRP ISKTVRFNVV KVSAAAGKAN 150
    KQFAKF 156
    Length:156
    Mass (Da):17,749
    Last modified:June 28, 2011 - v1
    Checksum:i6F7825FAE17EB084
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 132AF → FA AA sequence (PubMed:1544921)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L15408 Unassigned DNA. Translation: AAC37411.1.
    X95966 Genomic DNA. Translation: CAA65218.1.
    Z47814 Genomic DNA. Translation: CAA87804.1.
    Z74321 Genomic DNA. Translation: CAA98846.1.
    BK006938 Genomic DNA. Translation: DAA11870.1.
    PIRiS41784.
    RefSeqiNP_009604.1. NM_001178396.1.
    NP_010308.3. NM_001180333.3.

    Genome annotation databases

    EnsemblFungiiYBR048W; YBR048W; YBR048W.
    YDR025W; YDR025W; YDR025W.
    GeneIDi851589.
    852337.
    KEGGisce:YBR048W.
    sce:YDR025W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L15408 Unassigned DNA. Translation: AAC37411.1 .
    X95966 Genomic DNA. Translation: CAA65218.1 .
    Z47814 Genomic DNA. Translation: CAA87804.1 .
    Z74321 Genomic DNA. Translation: CAA98846.1 .
    BK006938 Genomic DNA. Translation: DAA11870.1 .
    PIRi S41784.
    RefSeqi NP_009604.1. NM_001178396.1.
    NP_010308.3. NM_001180333.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K5X model - Q 69-144 [» ]
    1S1H electron microscopy 11.70 Q 69-144 [» ]
    1VW9 electron microscopy 6.10 M 1-156 [» ]
    1VWV electron microscopy 6.10 M 1-156 [» ]
    3IZB electron microscopy - P 1-156 [» ]
    3O2Z X-ray 4.00 F 1-156 [» ]
    3O30 X-ray 4.00 F 1-156 [» ]
    3U5C X-ray 3.00 L 1-156 [» ]
    3U5G X-ray 3.00 L 1-156 [» ]
    4BYL electron microscopy 4.30 L 1-156 [» ]
    4BYT electron microscopy 6.60 L 1-156 [» ]
    4CUY electron microscopy 3.70 L 4-145 [» ]
    ProteinModelPortali P0CX47.
    SMRi P0CX47. Positions 2-156.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32075. 120 interactions.
    32750. 149 interactions.
    IntActi P0CX47. 1 interaction.
    MINTi MINT-8285636.

    Proteomic databases

    MaxQBi P0CX47.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR048W ; YBR048W ; YBR048W .
    YDR025W ; YDR025W ; YDR025W .
    GeneIDi 851589.
    852337.
    KEGGi sce:YBR048W.
    sce:YDR025W.

    Organism-specific databases

    CYGDi YDR025w.
    SGDi S000002432. RPS11A.

    Phylogenomic databases

    KOi K02949.
    OrthoDBi EOG7MD52Z.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29641-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    EvolutionaryTracei P0CX47.
    NextBioi 969066.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_01345_B. Ribosomal_S17_B.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR000266. Ribosomal_S17.
    IPR028333. Ribosomal_S17_arc-typ.
    IPR019979. Ribosomal_S17_CS.
    [Graphical view ]
    PANTHERi PTHR10744. PTHR10744. 1 hit.
    Pfami PF00366. Ribosomal_S17. 1 hit.
    [Graphical view ]
    PRINTSi PR00973. RIBOSOMALS17.
    ProDomi PD001295. Ribosomal_S17. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR03630. arch_S17P. 1 hit.
    PROSITEi PS00056. RIBOSOMAL_S17. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Reduced dosage of genes encoding ribosomal protein S18 suppresses a mitochondrial initiation codon mutation in Saccharomyces cerevisiae."
      Folley L.S., Fox T.D.
      Genetics 137:369-379(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Sequencing and analysis of a 35.4 kb region on the right arm of chromosome IV from Saccharomyces cerevisiae reveal 23 open reading frames."
      Eide L.G., Sander C., Prydz H.
      Yeast 12:1085-1090(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "NH2-terminal acetylation of ribosomal proteins of Saccharomyces cerevisiae."
      Takakura H., Tsunasawa S., Miyagi M., Warner J.R.
      J. Biol. Chem. 267:5442-5445(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-21, ACETYLATION AT SER-2 BY NATA.
    6. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    7. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2 BY NATA.
    8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
      Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
      Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 69-144, ELECTRON MICROSCOPY.
    12. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
      Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
      EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 69-144, ELECTRON MICROSCOPY.

    Entry informationi

    Entry nameiRS11A_YEAST
    AccessioniPrimary (citable) accession number: P0CX47
    Secondary accession number(s): D6VQ48, O11852, P26781
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are 2 genes for S11 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3