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Protein

60S ribosomal protein L1-A

Gene

RPL1A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: GO_Central
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • maturation of LSU-rRNA Source: GO_Central
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-34109-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L1-A
Alternative name(s):
L10a
Gene namesi
Name:RPL1A
Synonyms:SSM1, SSM1A
Ordered Locus Names:YPL220W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

SGDiS000006141. RPL1A.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources1 Publication
Chaini2 – 21721660S ribosomal protein L1-APRO_0000125842Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources1 Publication
Modified residuei47 – 471N6-methyllysine; by RKM51 Publication
Modified residuei79 – 791PhosphoserineCombined sources
Modified residuei86 – 861PhosphoserineCombined sources

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiP0CX43.
TopDownProteomicsiP0CX43.

PTM databases

iPTMnetiP0CX43.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi33117. 83 interactions.
35965. 85 interactions.
IntActiP0CX43. 3 interactions.
MINTiMINT-495020.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-A4-216[»]
2NOQelectron microscopy7.30G4-216[»]
3J0Pelectron microscopy10.60B4-216[»]
3J0Qelectron microscopy10.60B4-216[»]
3J6Xelectron microscopy6.10L11-217[»]
3J6Yelectron microscopy6.10L11-217[»]
3J77electron microscopy6.20L11-217[»]
3J78electron microscopy6.30L11-217[»]
4V4Belectron microscopy11.70BA1-217[»]
4V6Ielectron microscopy8.80BA1-217[»]
4V7Felectron microscopy8.70A1-217[»]
4V7Helectron microscopy8.90A4-216[»]
4V7RX-ray4.00BA/DA1-217[»]
4V91electron microscopy3.70t1-217[»]
ProteinModelPortaliP0CX43.
SMRiP0CX43. Positions 4-216.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CX43.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L1P family.Curated

Phylogenomic databases

InParanoidiP0CX43.
KOiK02865.
OrthoDBiEOG092C4PD0.

Family and domain databases

CDDicd00403. Ribosomal_L1. 1 hit.
Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
InterProiIPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023673. Ribosomal_L1_CS.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
PIRSFiPIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
PROSITEiPS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CX43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKITSSQVR EHVKELLKYS NETKKRNFLE TVELQVGLKN YDPQRDKRFS
60 70 80 90 100
GSLKLPNCPR PNMSICIFGD AFDVDRAKSC GVDAMSVDDL KKLNKNKKLI
110 120 130 140 150
KKLSKKYNAF IASEVLIKQV PRLLGPQLSK AGKFPTPVSH NDDLYGKVTD
160 170 180 190 200
VRSTIKFQLK KVLCLAVAVG NVEMEEDVLV NQILMSVNFF VSLLKKNWQN
210
VGSLVVKSSM GPAFRLY
Length:217
Mass (Da):24,486
Last modified:June 28, 2011 - v1
Checksum:iC890A90505655F2A
GO

Mass spectrometryi

Molecular mass is 24410.862 Da from positions 2 - 217. Determined by ESI. Average mass with 1 acetylation and 1 methylation modification.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70985 Genomic DNA. Translation: CAA50314.1.
Z73576 Genomic DNA. Translation: CAA97935.1.
BK006949 Genomic DNA. Translation: DAA11216.1.
PIRiS53893.
RefSeqiNP_011380.3. NM_001181000.3.
NP_015104.1. NM_001184034.1.

Genome annotation databases

EnsemblFungiiYGL135W; YGL135W; YGL135W.
YPL220W; YPL220W; YPL220W.
GeneIDi852742.
855881.
KEGGisce:YGL135W.
sce:YPL220W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70985 Genomic DNA. Translation: CAA50314.1.
Z73576 Genomic DNA. Translation: CAA97935.1.
BK006949 Genomic DNA. Translation: DAA11216.1.
PIRiS53893.
RefSeqiNP_011380.3. NM_001181000.3.
NP_015104.1. NM_001184034.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-A4-216[»]
2NOQelectron microscopy7.30G4-216[»]
3J0Pelectron microscopy10.60B4-216[»]
3J0Qelectron microscopy10.60B4-216[»]
3J6Xelectron microscopy6.10L11-217[»]
3J6Yelectron microscopy6.10L11-217[»]
3J77electron microscopy6.20L11-217[»]
3J78electron microscopy6.30L11-217[»]
4V4Belectron microscopy11.70BA1-217[»]
4V6Ielectron microscopy8.80BA1-217[»]
4V7Felectron microscopy8.70A1-217[»]
4V7Helectron microscopy8.90A4-216[»]
4V7RX-ray4.00BA/DA1-217[»]
4V91electron microscopy3.70t1-217[»]
ProteinModelPortaliP0CX43.
SMRiP0CX43. Positions 4-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33117. 83 interactions.
35965. 85 interactions.
IntActiP0CX43. 3 interactions.
MINTiMINT-495020.

PTM databases

iPTMnetiP0CX43.

Proteomic databases

MaxQBiP0CX43.
TopDownProteomicsiP0CX43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL135W; YGL135W; YGL135W.
YPL220W; YPL220W; YPL220W.
GeneIDi852742.
855881.
KEGGisce:YGL135W.
sce:YPL220W.

Organism-specific databases

SGDiS000006141. RPL1A.

Phylogenomic databases

InParanoidiP0CX43.
KOiK02865.
OrthoDBiEOG092C4PD0.

Enzyme and pathway databases

BioCyciYEAST:G3O-34109-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

EvolutionaryTraceiP0CX43.
PROiP0CX43.

Family and domain databases

CDDicd00403. Ribosomal_L1. 1 hit.
Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
InterProiIPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023673. Ribosomal_L1_CS.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
PIRSFiPIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
PROSITEiPS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL1A_YEAST
AccessioniPrimary (citable) accession number: P0CX43
Secondary accession number(s): D6VU14, P53030
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 7, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 116000 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for L1 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.