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Protein

60S ribosomal protein L1-A

Gene

RPL1A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL1 forms part of the L1 stalk, a mobile element that plays a role in evacuating the exit-site tRNA.1 Publication

Miscellaneous

Present with 116000 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for uL1 in yeast.Curated

GO - Molecular functioni

  • RNA binding Source: GO_Central
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • maturation of LSU-rRNA Source: GO_Central
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-34109-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L1-A1 Publication
Alternative name(s):
L10a
Large ribosomal subunit protein uL1-A1 Publication
Gene namesi
Name:RPL1A1 Publication
Synonyms:SSM1, SSM1A
Ordered Locus Names:YPL220W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

SGDiS000006141 RPL1A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001258422 – 21760S ribosomal protein L1-AAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei47N6-methyllysine; by RKM51 Publication1
Modified residuei79PhosphoserineCombined sources1
Modified residuei86PhosphoserineCombined sources1

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiP0CX43
PaxDbiP0CX43
PRIDEiP0CX43
TopDownProteomicsiP0CX43

PTM databases

iPTMnetiP0CX43

Expressioni

Gene expression databases

ExpressionAtlasiP0CX43 differential

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uL1 forms part of the L1 stalk (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi33117, 173 interactors
35965, 134 interactors
IntActiP0CX43, 3 interactors
MINTiP0CX43
STRINGi4932.YPL220W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-A4-216[»]
2NOQelectron microscopy7.30G4-216[»]
3J0Pelectron microscopy10.60B4-216[»]
3J0Qelectron microscopy10.60B4-216[»]
3J6Xelectron microscopy6.10L11-217[»]
3J6Yelectron microscopy6.10L11-217[»]
3J77electron microscopy6.20L11-217[»]
3J78electron microscopy6.30L11-217[»]
4V4Belectron microscopy11.70BA1-217[»]
4V6Ielectron microscopy8.80BA1-217[»]
4V7Felectron microscopy8.70A1-217[»]
4V7Helectron microscopy8.90A4-216[»]
4V7RX-ray4.00BA/DA1-217[»]
4V91electron microscopy3.70t1-217[»]
5JCSelectron microscopy9.50I1-217[»]
5JUOelectron microscopy4.00E1-217[»]
5JUPelectron microscopy3.50E1-217[»]
5JUSelectron microscopy4.20E1-217[»]
5JUTelectron microscopy4.00E1-217[»]
5JUUelectron microscopy4.00E1-217[»]
ProteinModelPortaliP0CX43
SMRiP0CX43
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CX43

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiP0CX43
KOiK02865
OMAiIHLAINF
OrthoDBiEOG092C4PD0

Family and domain databases

CDDicd00403 Ribosomal_L1, 1 hit
Gene3Di3.40.50.790, 1 hit
InterProiView protein in InterPro
IPR002143 Ribosomal_L1
IPR023674 Ribosomal_L1-like
IPR028364 Ribosomal_L1/biogenesis
IPR016095 Ribosomal_L1_3-a/b-sand
IPR023673 Ribosomal_L1_CS
PfamiView protein in Pfam
PF00687 Ribosomal_L1, 1 hit
PIRSFiPIRSF002155 Ribosomal_L1, 1 hit
SUPFAMiSSF56808 SSF56808, 1 hit
PROSITEiView protein in PROSITE
PS01199 RIBOSOMAL_L1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CX43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKITSSQVR EHVKELLKYS NETKKRNFLE TVELQVGLKN YDPQRDKRFS
60 70 80 90 100
GSLKLPNCPR PNMSICIFGD AFDVDRAKSC GVDAMSVDDL KKLNKNKKLI
110 120 130 140 150
KKLSKKYNAF IASEVLIKQV PRLLGPQLSK AGKFPTPVSH NDDLYGKVTD
160 170 180 190 200
VRSTIKFQLK KVLCLAVAVG NVEMEEDVLV NQILMSVNFF VSLLKKNWQN
210
VGSLVVKSSM GPAFRLY
Length:217
Mass (Da):24,486
Last modified:June 28, 2011 - v1
Checksum:iC890A90505655F2A
GO

Mass spectrometryi

Molecular mass is 24410.862 Da from positions 2 - 217. Determined by ESI. Average mass with 1 acetylation and 1 methylation modification.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70985 Genomic DNA Translation: CAA50314.1
Z73576 Genomic DNA Translation: CAA97935.1
BK006949 Genomic DNA Translation: DAA11216.1
PIRiS53893
RefSeqiNP_011380.3, NM_001181000.3
NP_015104.1, NM_001184034.1

Genome annotation databases

EnsemblFungiiYGL135W; YGL135W; YGL135W
YPL220W; YPL220W; YPL220W
GeneIDi852742
855881
KEGGisce:YGL135W
sce:YPL220W

Similar proteinsi

Entry informationi

Entry nameiRL1A_YEAST
AccessioniPrimary (citable) accession number: P0CX43
Secondary accession number(s): D6VU14, P53030
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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