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P0CX41

- RL23A_YEAST

UniProt

P0CX41 - RL23A_YEAST

Protein

60S ribosomal protein L23-A

Gene

RPL23A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28976-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L23-A
    Alternative name(s):
    L17a
    YL32
    Gene namesi
    Name:RPL23A
    Synonyms:RPL17A, RPL17AA
    Ordered Locus Names:YBL087C
    ORF Names:YBL0713
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBL087c.
    SGDiS000000183. RPL23A.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 13713660S ribosomal protein L23-APRO_0000128630Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications
    Modified residuei40 – 401N6,N6-dimethyllysine; by RKM11 Publication
    Modified residuei106 – 1061N6,N6-dimethyllysine; by RKM11 Publication
    Modified residuei110 – 1101N6,N6-dimethyllysine; by RKM11 Publication

    Post-translational modificationi

    Methylated by RKM1 at 2 different sites, but it is unclear which are the 2 methylated residues among Lys-40, Lys-106 and/or Lys-110.1 Publication

    Keywords - PTMi

    Acetylation, Methylation

    Proteomic databases

    MaxQBiP0CX41.

    Interactioni

    Subunit structurei

    Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi32617. 91 interactions.
    36862. 25 interactions.
    IntActiP0CX41. 1 interaction.
    MINTiMINT-515434.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K5Ymodel-R7-137[»]
    1S1Ielectron microscopy11.70R1-137[»]
    1VW8electron microscopy6.10W1-137[»]
    1VWUelectron microscopy6.10W1-137[»]
    2X7Nelectron microscopy11.80C6-137[»]
    3IZSelectron microscopy-M1-137[»]
    3J16electron microscopy-I1-137[»]
    3J65electron microscopy8.70L1-137[»]
    3O58X-ray4.00U1-137[»]
    3O5HX-ray4.00U1-137[»]
    3U5EX-ray3.00V1-137[»]
    3U5IX-ray3.00V1-137[»]
    4B6Aelectron microscopy8.10V1-137[»]
    4BYNelectron microscopy4.30V2-137[»]
    4BYUelectron microscopy6.60V2-137[»]
    4CUWelectron microscopy3.70V1-137[»]
    ProteinModelPortaliP0CX41.
    SMRiP0CX41. Positions 2-137.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0CX41.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L14P family.Curated

    Phylogenomic databases

    HOGENOMiHOG000183703.
    KOiK02894.
    OrthoDBiEOG7N0CHC.

    Family and domain databases

    Gene3Di2.40.150.20. 1 hit.
    HAMAPiMF_01367. Ribosomal_L14.
    InterProiIPR019972. Ribosomal_L14_CS.
    IPR023571. Ribosomal_L14_dom.
    IPR000218. Ribosomal_L14b/L23e.
    [Graphical view]
    PANTHERiPTHR11761. PTHR11761. 1 hit.
    PfamiPF00238. Ribosomal_L14. 1 hit.
    [Graphical view]
    SUPFAMiSSF50193. SSF50193. 1 hit.
    PROSITEiPS00049. RIBOSOMAL_L14. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0CX41-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGNGAQGTK FRISLGLPVG AIMNCADNSG ARNLYIIAVK GSGSRLNRLP    50
    AASLGDMVMA TVKKGKPELR KKVMPAIVVR QAKSWRRRDG VFLYFEDNAG 100
    VIANPKGEMK GSAITGPVGK ECADLWPRVA SNSGVVV 137
    Length:137
    Mass (Da):14,473
    Last modified:June 28, 2011 - v1
    Checksum:iDEB983B3CB1DFAB1
    GO

    Mass spectrometryi

    Molecular mass is 14430.702 Da from positions 2 - 137. Determined by ESI. Monoisotopic mass with either 7 methylation modifications or 1 acetylation and 4 methylation modifications.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01694 Genomic DNA. Translation: CAA25841.1.
    X79489 Genomic DNA. Translation: CAA56018.1.
    Z35848 Genomic DNA. Translation: CAA84908.1.
    BK006936 Genomic DNA. Translation: DAA07037.1.
    PIRiA02792. R5BY17.
    RefSeqiNP_009466.1. NM_001178327.1.
    NP_011042.3. NM_001179007.3.

    Genome annotation databases

    EnsemblFungiiYBL087C; YBL087C; YBL087C.
    YER117W; YER117W; YER117W.
    GeneIDi852191.
    856853.
    KEGGisce:YBL087C.
    sce:YER117W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01694 Genomic DNA. Translation: CAA25841.1 .
    X79489 Genomic DNA. Translation: CAA56018.1 .
    Z35848 Genomic DNA. Translation: CAA84908.1 .
    BK006936 Genomic DNA. Translation: DAA07037.1 .
    PIRi A02792. R5BY17.
    RefSeqi NP_009466.1. NM_001178327.1.
    NP_011042.3. NM_001179007.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K5Y model - R 7-137 [» ]
    1S1I electron microscopy 11.70 R 1-137 [» ]
    1VW8 electron microscopy 6.10 W 1-137 [» ]
    1VWU electron microscopy 6.10 W 1-137 [» ]
    2X7N electron microscopy 11.80 C 6-137 [» ]
    3IZS electron microscopy - M 1-137 [» ]
    3J16 electron microscopy - I 1-137 [» ]
    3J65 electron microscopy 8.70 L 1-137 [» ]
    3O58 X-ray 4.00 U 1-137 [» ]
    3O5H X-ray 4.00 U 1-137 [» ]
    3U5E X-ray 3.00 V 1-137 [» ]
    3U5I X-ray 3.00 V 1-137 [» ]
    4B6A electron microscopy 8.10 V 1-137 [» ]
    4BYN electron microscopy 4.30 V 2-137 [» ]
    4BYU electron microscopy 6.60 V 2-137 [» ]
    4CUW electron microscopy 3.70 V 1-137 [» ]
    ProteinModelPortali P0CX41.
    SMRi P0CX41. Positions 2-137.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32617. 91 interactions.
    36862. 25 interactions.
    IntActi P0CX41. 1 interaction.
    MINTi MINT-515434.

    Proteomic databases

    MaxQBi P0CX41.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBL087C ; YBL087C ; YBL087C .
    YER117W ; YER117W ; YER117W .
    GeneIDi 852191.
    856853.
    KEGGi sce:YBL087C.
    sce:YER117W.

    Organism-specific databases

    CYGDi YBL087c.
    SGDi S000000183. RPL23A.

    Phylogenomic databases

    HOGENOMi HOG000183703.
    KOi K02894.
    OrthoDBi EOG7N0CHC.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28976-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    EvolutionaryTracei P0CX41.
    NextBioi 970670.

    Family and domain databases

    Gene3Di 2.40.150.20. 1 hit.
    HAMAPi MF_01367. Ribosomal_L14.
    InterProi IPR019972. Ribosomal_L14_CS.
    IPR023571. Ribosomal_L14_dom.
    IPR000218. Ribosomal_L14b/L23e.
    [Graphical view ]
    PANTHERi PTHR11761. PTHR11761. 1 hit.
    Pfami PF00238. Ribosomal_L14. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50193. SSF50193. 1 hit.
    PROSITEi PS00049. RIBOSOMAL_L14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence analysis of a 78.6 kb segment of the left end of Saccharomyces cerevisiae chromosome II."
      Obermaier B., Gassenhuber J., Piravandi E., Domdey H.
      Yeast 11:1103-1112(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    6. "Direct mass spectrometric analysis of intact proteins of the yeast large ribosomal subunit using capillary LC/FTICR."
      Lee S.-W., Berger S.J., Martinovic S., Pasa-Tolic L., Anderson G.A., Shen Y., Zhao R., Smith R.D.
      Proc. Natl. Acad. Sci. U.S.A. 99:5942-5947(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: MASS SPECTROMETRY.
    7. "A novel SET domain methyltransferase modifies ribosomal protein Rpl23ab in yeast."
      Porras-Yakushi T.R., Whitelegge J.P., Miranda T.B., Clarke S.
      J. Biol. Chem. 280:34590-34598(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION AT SER-2, METHYLATION AT LYS-40; LYS-106 AND LYS-110.
    8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
      Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
      Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 7-137, ELECTRON MICROSCOPY.
    10. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
      Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
      EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.
    11. "Crystal structure of the eukaryotic ribosome."
      Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
      Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
    12. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL23A_YEAST
    AccessioniPrimary (citable) accession number: P0CX41
    Secondary accession number(s): D3DM23, P04451
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are 2 genes for L23 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3