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Protein

60S ribosomal protein L23-A

Gene

RPL23A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

There are 2 genes for uL14 in yeast.Curated

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-28976-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L23-A1 Publication
Alternative name(s):
L17a
Large ribosomal subunit protein uL14-A1 Publication
YL32
Gene namesi
Name:RPL23A1 Publication
Synonyms:RPL17A, RPL17AA
Ordered Locus Names:YBL087C
ORF Names:YBL0713
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

SGDiS000000183 RPL23A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001286302 – 13760S ribosomal protein L23-AAdd BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei106N6,N6-dimethyllysine; by RKM11 Publication1
Modified residuei110N6,N6-dimethyllysine; by RKM11 Publication1

Post-translational modificationi

Methylated by RKM1 at 2 different sites, but it is unclear which are the 2 methylated residues among Lys-40, Lys-106 and/or Lys-110.1 Publication

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

MaxQBiP0CX41
PaxDbiP0CX41
PRIDEiP0CX41
TopDownProteomicsiP0CX41

PTM databases

iPTMnetiP0CX41

Expressioni

Gene expression databases

ExpressionAtlasiP0CX41 differential

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi32617, 213 interactors
36862, 152 interactors
IntActiP0CX41, 2 interactors
MINTiP0CX41
STRINGi4932.YER117W

Structurei

Secondary structure

1137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 25Combined sources4
Beta strandi27 – 31Combined sources5
Beta strandi33 – 39Combined sources7
Beta strandi57 – 61Combined sources5
Beta strandi63 – 65Combined sources3
Helixi67 – 69Combined sources3
Beta strandi70 – 72Combined sources3
Beta strandi74 – 80Combined sources7
Beta strandi92 – 97Combined sources6
Beta strandi99 – 103Combined sources5
Turni105 – 107Combined sources3
Beta strandi109 – 112Combined sources4
Helixi120 – 123Combined sources4
Helixi127 – 131Combined sources5
Beta strandi134 – 136Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-R7-137[»]
2X7Nelectron microscopy11.80C6-137[»]
3J16electron microscopy-I1-137[»]
3J6Xelectron microscopy6.10631-137[»]
3J6Yelectron microscopy6.10631-137[»]
3J77electron microscopy6.20731-137[»]
3J78electron microscopy6.30731-137[»]
3JCTelectron microscopy3.08V1-137[»]
4U3MX-ray3.00N3/n32-137[»]
4U3NX-ray3.20N3/n32-137[»]
4U3UX-ray2.90N3/n32-137[»]
4U4NX-ray3.10N3/n32-137[»]
4U4OX-ray3.60N3/n32-137[»]
4U4QX-ray3.00N3/n32-137[»]
4U4RX-ray2.80N3/n32-137[»]
4U4UX-ray3.00N3/n32-137[»]
4U4YX-ray3.20N3/n32-137[»]
4U4ZX-ray3.10N3/n32-137[»]
4U50X-ray3.20N3/n32-137[»]
4U51X-ray3.20N3/n32-137[»]
4U52X-ray3.00N3/n32-137[»]
4U53X-ray3.30N3/n32-137[»]
4U55X-ray3.20N3/n32-137[»]
4U56X-ray3.45N3/n32-137[»]
4U6FX-ray3.10N3/n32-137[»]
4V4Belectron microscopy11.70BR1-137[»]
4V6Ielectron microscopy8.80BM1-137[»]
4V7Felectron microscopy8.70L1-137[»]
4V7RX-ray4.00BU/DU1-137[»]
4V88X-ray3.00BV/DV1-137[»]
4V8Telectron microscopy8.10V1-137[»]
4V8Yelectron microscopy4.30BV2-137[»]
4V8Zelectron microscopy6.60BV2-137[»]
4V91electron microscopy3.70V1-137[»]
5APNelectron microscopy3.91V1-137[»]
5APOelectron microscopy3.41V1-137[»]
5DATX-ray3.15N3/n32-137[»]
5DC3X-ray3.25N3/n32-137[»]
5DGEX-ray3.45N3/n32-137[»]
5DGFX-ray3.30N3/n32-137[»]
5DGVX-ray3.10N3/n32-137[»]
5FCIX-ray3.40N3/n32-137[»]
5FCJX-ray3.10N3/n32-137[»]
5FL8electron microscopy9.50V1-137[»]
5GAKelectron microscopy3.88X1-137[»]
5H4Pelectron microscopy3.07V1-137[»]
5I4LX-ray3.10N3/n32-137[»]
5JCSelectron microscopy9.50V1-137[»]
5JUOelectron microscopy4.00AA1-137[»]
5JUPelectron microscopy3.50AA1-137[»]
5JUSelectron microscopy4.20AA1-137[»]
5JUTelectron microscopy4.00AA1-137[»]
5JUUelectron microscopy4.00AA1-137[»]
5LYBX-ray3.25N3/n32-137[»]
5M1Jelectron microscopy3.30V52-137[»]
5MC6electron microscopy3.80AB1-137[»]
5MEIX-ray3.50CX/l22-137[»]
5NDGX-ray3.70N3/n33-137[»]
5NDVX-ray3.30N3/n32-137[»]
5NDWX-ray3.70N3/n32-137[»]
5OBMX-ray3.40N3/n32-137[»]
5ON6X-ray3.10CX/lR2-137[»]
5T62electron microscopy3.30i1-137[»]
5T6Relectron microscopy4.50i1-137[»]
5TBWX-ray3.006/CX2-137[»]
5TGAX-ray3.30N3/n32-137[»]
5TGMX-ray3.50N3/n32-137[»]
6C0Felectron microscopy3.70V1-137[»]
6ELZelectron microscopy3.30V1-137[»]
6EM1electron microscopy3.60V1-137[»]
6EM4electron microscopy4.10V1-137[»]
6EM5electron microscopy4.30V1-137[»]
6FT6electron microscopy3.90V1-137[»]
ProteinModelPortaliP0CX41
SMRiP0CX41
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CX41

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000183703
InParanoidiP0CX41
KOiK02894
OMAiELRKKTM
OrthoDBiEOG092C5AG7

Family and domain databases

Gene3Di2.40.150.20, 1 hit
HAMAPiMF_01367 Ribosomal_L14, 1 hit
InterProiView protein in InterPro
IPR036853 Ribosomal_L14_sf
IPR000218 Ribosomal_L14P
IPR019972 Ribosomal_L14P_CS
PANTHERiPTHR11761 PTHR11761, 1 hit
PfamiView protein in Pfam
PF00238 Ribosomal_L14, 1 hit
SMARTiView protein in SMART
SM01374 Ribosomal_L14, 1 hit
SUPFAMiSSF50193 SSF50193, 1 hit
PROSITEiView protein in PROSITE
PS00049 RIBOSOMAL_L14, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CX41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGNGAQGTK FRISLGLPVG AIMNCADNSG ARNLYIIAVK GSGSRLNRLP
60 70 80 90 100
AASLGDMVMA TVKKGKPELR KKVMPAIVVR QAKSWRRRDG VFLYFEDNAG
110 120 130
VIANPKGEMK GSAITGPVGK ECADLWPRVA SNSGVVV
Length:137
Mass (Da):14,473
Last modified:June 28, 2011 - v1
Checksum:iDEB983B3CB1DFAB1
GO

Mass spectrometryi

Molecular mass is 14430.702 Da from positions 2 - 137. Determined by ESI. Monoisotopic mass with either 7 methylation modifications or 1 acetylation and 4 methylation modifications.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01694 Genomic DNA Translation: CAA25841.1
X79489 Genomic DNA Translation: CAA56018.1
Z35848 Genomic DNA Translation: CAA84908.1
BK006936 Genomic DNA Translation: DAA07037.1
PIRiA02792 R5BY17
RefSeqiNP_009466.1, NM_001178327.1
NP_011042.3, NM_001179007.3

Genome annotation databases

EnsemblFungiiYBL087C; YBL087C; YBL087C
YER117W; YER117W; YER117W
GeneIDi852191
856853
KEGGisce:YBL087C
sce:YER117W

Similar proteinsi

Entry informationi

Entry nameiRL23A_YEAST
AccessioniPrimary (citable) accession number: P0CX41
Secondary accession number(s): D3DM23, P04451
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: June 20, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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