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P0CX38

- RS6B_YEAST

UniProt

P0CX38 - RS6B_YEAST

Protein

40S ribosomal protein S6-B

Gene

RPS6B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.1 Publication

    GO - Molecular functioni

    1. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD
    2. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29125-MONOMER.
    ReactomeiREACT_188483. S6K1 signalling.
    REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S6-B
    Alternative name(s):
    RP9
    S10
    YS4
    Gene namesi
    Name:RPS6B
    Synonyms:RPS102, RPS10A
    Ordered Locus Names:YBR181C
    ORF Names:YBR1244
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR181c.
    SGDiS000000385. RPS6B.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosolic small ribosomal subunit Source: SGD
    2. nucleolus Source: UniProtKB-SubCell
    3. small-subunit processome Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 23623640S ribosomal protein S6-BPRO_0000409765Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei163 – 1631Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.2 Publications

    Protein-protein interaction databases

    BioGridi32879. 158 interactions.
    36091. 153 interactions.
    IntActiP0CX38. 1 interaction.
    MINTiMINT-1325449.

    Structurei

    3D structure databases

    ProteinModelPortaliP0CX38.
    SMRiP0CX38. Positions 1-226.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S6e family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00390000009819.
    KOiK02991.
    OrthoDBiEOG71GB67.

    Family and domain databases

    InterProiIPR014401. Ribosomal_S6_euk.
    IPR001377. Ribosomal_S6e.
    IPR018282. Ribosomal_S6e_CS.
    [Graphical view]
    PANTHERiPTHR11502. PTHR11502. 1 hit.
    PfamiPF01092. Ribosomal_S6e. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002129. Ribosom_S6_euk. 1 hit.
    PROSITEiPS00578. RIBOSOMAL_S6E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CX38-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLNISYPVN GSQKTFEIDD EHRIRVFFDK RIGQEVDGEA VGDEFKGYVF    50
    KISGGNDKQG FPMKQGVLLP TRIKLLLTKN VSCYRPRRDG ERKRKSVRGA 100
    IVGPDLAVLA LVIVKKGEQE LEGLTDTTVP KRLGPKRANN IRKFFGLSKE 150
    DDVRDFVIRR EVTKGEKTYT KAPKIQRLVT PQRLQRKRHQ RALKVRNAQA 200
    QREAAAEYAQ LLAKRLSERK AEKAEIRKRR ASSLKA 236
    Length:236
    Mass (Da):26,996
    Last modified:June 28, 2011 - v1
    Checksum:i78B523BB7FDABEE0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti181 – 1811P → S in J01350. (PubMed:6292856)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01350 Genomic DNA. No translation available.
    Z36050 Genomic DNA. Translation: CAA85142.1.
    BK006936 Genomic DNA. Translation: DAA07295.1.
    PIRiA23787. R3BY10.
    RefSeqiNP_009740.3. NM_001178529.3.
    NP_015235.1. NM_001183904.1.

    Genome annotation databases

    EnsemblFungiiYBR181C; YBR181C; YBR181C.
    YPL090C; YPL090C; YPL090C.
    GeneIDi852479.
    856015.
    KEGGisce:YBR181C.
    sce:YPL090C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J01350 Genomic DNA. No translation available.
    Z36050 Genomic DNA. Translation: CAA85142.1 .
    BK006936 Genomic DNA. Translation: DAA07295.1 .
    PIRi A23787. R3BY10.
    RefSeqi NP_009740.3. NM_001178529.3.
    NP_015235.1. NM_001183904.1.

    3D structure databases

    ProteinModelPortali P0CX38.
    SMRi P0CX38. Positions 1-226.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32879. 158 interactions.
    36091. 153 interactions.
    IntActi P0CX38. 1 interaction.
    MINTi MINT-1325449.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR181C ; YBR181C ; YBR181C .
    YPL090C ; YPL090C ; YPL090C .
    GeneIDi 852479.
    856015.
    KEGGi sce:YBR181C.
    sce:YPL090C.

    Organism-specific databases

    CYGDi YBR181c.
    SGDi S000000385. RPS6B.

    Phylogenomic databases

    GeneTreei ENSGT00390000009819.
    KOi K02991.
    OrthoDBi EOG71GB67.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29125-MONOMER.
    Reactomei REACT_188483. S6K1 signalling.
    REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    NextBioi 971447.

    Family and domain databases

    InterProi IPR014401. Ribosomal_S6_euk.
    IPR001377. Ribosomal_S6e.
    IPR018282. Ribosomal_S6e_CS.
    [Graphical view ]
    PANTHERi PTHR11502. PTHR11502. 1 hit.
    Pfami PF01092. Ribosomal_S6e. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002129. Ribosom_S6_euk. 1 hit.
    PROSITEi PS00578. RIBOSOMAL_S6E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The structure of the gene coding for the phosphorylated ribosomal protein S10 in yeast."
      Leer R.J., van Raamsdonk-Duin M.M.C., Molenaar C.M.T., Cohen L.H., Mager W.H., Planta R.J.
      Nucleic Acids Res. 10:5869-5878(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Carlsbergensis.
    2. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Isolation of seventeen proteins and amino-terminal amino acid sequences of eight proteins from cytoplasmic ribosomes of yeast."
      Otaka E., Higo K., Osawa S.
      Biochemistry 21:4545-4550(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY PROTEIN SEQUENCE OF 1-30.
    5. "Yeast ribosomal proteins: VII. Cytoplasmic ribosomal proteins from Schizosaccharomyces pombe."
      Otaka E., Higo K., Itoh T.
      Mol. Gen. Genet. 191:519-524(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO 1.
    6. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    9. "The small-subunit processome is a ribosome assembly intermediate."
      Bernstein K.A., Gallagher J.E.G., Mitchell B.M., Granneman S., Baserga S.J.
      Eukaryot. Cell 3:1619-1626(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME, SUBCELLULAR LOCATION.
    10. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-163, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRS6B_YEAST
    AccessioniPrimary (citable) accession number: P0CX38
    Secondary accession number(s): D6VQH5
    , P02365, P05751, Q02894
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 38800 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for S6 in yeast.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Ribosomal proteins
      Ribosomal proteins families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3