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Protein

40S ribosomal protein S24-A

Gene

RPS24A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-30245-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-SCE-72702. Ribosomal scanning and start codon recognition.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S24-A
Alternative name(s):
RP50
Gene namesi
Name:RPS24A
Synonyms:RPS24EA
Ordered Locus Names:YER074W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

SGDiS000000876. RPS24A.

Subcellular locationi

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources2 Publications
ChainiPRO_00001376362 – 13540S ribosomal protein S24-AAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources2 Publications1
Modified residuei14PhosphoserineCombined sources1
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei56PhosphoserineCombined sources1

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA. Also partially acetylated by NatC.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP0CX31.
PRIDEiP0CX31.
TopDownProteomicsiP0CX31.

PTM databases

iPTMnetiP0CX31.

Expressioni

Gene expression databases

ExpressionAtlasiP0CX31. baseline.

Interactioni

Subunit structurei

Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi34923. 76 interactors.
36817. 127 interactors.

Structurei

Secondary structure

1135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 15Combined sources9
Helixi16 – 18Combined sources3
Beta strandi20 – 28Combined sources9
Beta strandi30 – 32Combined sources3
Helixi37 – 45Combined sources9
Turni46 – 49Combined sources4
Helixi52 – 54Combined sources3
Beta strandi55 – 62Combined sources8
Beta strandi66 – 77Combined sources12
Helixi79 – 85Combined sources7
Helixi88 – 94Combined sources7
Beta strandi95 – 97Combined sources3
Helixi105 – 115Combined sources11
Beta strandi120 – 122Combined sources3
Helixi123 – 132Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J16electron microscopy-D1-135[»]
3J6Xelectron microscopy6.10241-135[»]
3J6Yelectron microscopy6.10241-135[»]
3J77electron microscopy6.20241-135[»]
3J78electron microscopy6.30241-135[»]
3V88X-ray3.00Y1-135[»]
4U3MX-ray3.00D4/d42-135[»]
4U3NX-ray3.20D4/d42-135[»]
4U3UX-ray2.90D4/d42-135[»]
4U4NX-ray3.10D4/d42-135[»]
4U4OX-ray3.60D4/d42-135[»]
4U4QX-ray3.00D4/d42-135[»]
4U4RX-ray2.80D4/d42-135[»]
4U4UX-ray3.00D4/d42-135[»]
4U4YX-ray3.20D4/d42-135[»]
4U4ZX-ray3.10D4/d42-135[»]
4U50X-ray3.20D4/d42-135[»]
4U51X-ray3.20D4/d42-135[»]
4U52X-ray3.00D4/d42-135[»]
4U53X-ray3.30D4/d42-135[»]
4U55X-ray3.20D4/d42-135[»]
4U56X-ray3.45D4/d42-135[»]
4U6FX-ray3.10D4/d42-135[»]
4V6Ielectron microscopy8.80AU1-135[»]
4V88X-ray3.00AY/CY1-135[»]
4V8Yelectron microscopy4.30AY1-135[»]
4V8Zelectron microscopy6.60AY1-135[»]
4V92electron microscopy3.70Y2-135[»]
5DATX-ray3.15D4/d42-135[»]
5DC3X-ray3.25D4/d42-135[»]
5FCIX-ray3.40D4/d42-135[»]
5FCJX-ray3.10D4/d42-135[»]
5I4LX-ray3.10D4/d42-135[»]
5JUOelectron microscopy4.00VB1-135[»]
5JUPelectron microscopy3.50VB1-135[»]
5JUSelectron microscopy4.20VB1-135[»]
5JUTelectron microscopy4.00VB1-135[»]
5JUUelectron microscopy4.00VB1-135[»]
ProteinModelPortaliP0CX31.
SMRiP0CX31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S24e family.Curated

Phylogenomic databases

HOGENOMiHOG000186306.
InParanoidiP0CX31.
KOiK02974.
OrthoDBiEOG092C5MLH.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
HAMAPiMF_00545. Ribosomal_S24e. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR001976. Ribosomal_S24e.
IPR018098. Ribosomal_S24e_CS.
[Graphical view]
PANTHERiPTHR10496. PTHR10496. 1 hit.
PfamiPF01282. Ribosomal_S24e. 1 hit.
[Graphical view]
ProDomiPD006052. Ribosomal_S24e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54189. SSF54189. 1 hit.
PROSITEiPS00529. RIBOSOMAL_S24E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CX31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAVTIRTR KVISNPLLAR KQFVVDVLHP NRANVSKDEL REKLAEVYKA
60 70 80 90 100
EKDAVSVFGF RTQFGGGKSV GFGLVYNSVA EAKKFEPTYR LVRYGLAEKV
110 120 130
EKASRQQRKQ KKNRDKKIFG TGKRLAKKVA RRNAD
Length:135
Mass (Da):15,329
Last modified:June 28, 2011 - v1
Checksum:i81B82D361207442A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16P → D AA sequence (PubMed:1544921).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18814 Genomic DNA. Translation: AAB64613.1.
BK006939 Genomic DNA. Translation: DAA07733.1.
PIRiS48410.
RefSeqiNP_010997.3. NM_001178965.3.
NP_012195.1. NM_001179419.1.

Genome annotation databases

EnsemblFungiiYER074W; YER074W; YER074W.
YIL069C; YIL069C; YIL069C.
GeneIDi854741.
856805.
KEGGisce:YER074W.
sce:YIL069C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18814 Genomic DNA. Translation: AAB64613.1.
BK006939 Genomic DNA. Translation: DAA07733.1.
PIRiS48410.
RefSeqiNP_010997.3. NM_001178965.3.
NP_012195.1. NM_001179419.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J16electron microscopy-D1-135[»]
3J6Xelectron microscopy6.10241-135[»]
3J6Yelectron microscopy6.10241-135[»]
3J77electron microscopy6.20241-135[»]
3J78electron microscopy6.30241-135[»]
3V88X-ray3.00Y1-135[»]
4U3MX-ray3.00D4/d42-135[»]
4U3NX-ray3.20D4/d42-135[»]
4U3UX-ray2.90D4/d42-135[»]
4U4NX-ray3.10D4/d42-135[»]
4U4OX-ray3.60D4/d42-135[»]
4U4QX-ray3.00D4/d42-135[»]
4U4RX-ray2.80D4/d42-135[»]
4U4UX-ray3.00D4/d42-135[»]
4U4YX-ray3.20D4/d42-135[»]
4U4ZX-ray3.10D4/d42-135[»]
4U50X-ray3.20D4/d42-135[»]
4U51X-ray3.20D4/d42-135[»]
4U52X-ray3.00D4/d42-135[»]
4U53X-ray3.30D4/d42-135[»]
4U55X-ray3.20D4/d42-135[»]
4U56X-ray3.45D4/d42-135[»]
4U6FX-ray3.10D4/d42-135[»]
4V6Ielectron microscopy8.80AU1-135[»]
4V88X-ray3.00AY/CY1-135[»]
4V8Yelectron microscopy4.30AY1-135[»]
4V8Zelectron microscopy6.60AY1-135[»]
4V92electron microscopy3.70Y2-135[»]
5DATX-ray3.15D4/d42-135[»]
5DC3X-ray3.25D4/d42-135[»]
5FCIX-ray3.40D4/d42-135[»]
5FCJX-ray3.10D4/d42-135[»]
5I4LX-ray3.10D4/d42-135[»]
5JUOelectron microscopy4.00VB1-135[»]
5JUPelectron microscopy3.50VB1-135[»]
5JUSelectron microscopy4.20VB1-135[»]
5JUTelectron microscopy4.00VB1-135[»]
5JUUelectron microscopy4.00VB1-135[»]
ProteinModelPortaliP0CX31.
SMRiP0CX31.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34923. 76 interactors.
36817. 127 interactors.

PTM databases

iPTMnetiP0CX31.

Proteomic databases

MaxQBiP0CX31.
PRIDEiP0CX31.
TopDownProteomicsiP0CX31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYER074W; YER074W; YER074W.
YIL069C; YIL069C; YIL069C.
GeneIDi854741.
856805.
KEGGisce:YER074W.
sce:YIL069C.

Organism-specific databases

SGDiS000000876. RPS24A.

Phylogenomic databases

HOGENOMiHOG000186306.
InParanoidiP0CX31.
KOiK02974.
OrthoDBiEOG092C5MLH.

Enzyme and pathway databases

BioCyciYEAST:G3O-30245-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-SCE-72702. Ribosomal scanning and start codon recognition.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP0CX31.

Gene expression databases

ExpressionAtlasiP0CX31. baseline.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
HAMAPiMF_00545. Ribosomal_S24e. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR001976. Ribosomal_S24e.
IPR018098. Ribosomal_S24e_CS.
[Graphical view]
PANTHERiPTHR10496. PTHR10496. 1 hit.
PfamiPF01282. Ribosomal_S24e. 1 hit.
[Graphical view]
ProDomiPD006052. Ribosomal_S24e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54189. SSF54189. 1 hit.
PROSITEiPS00529. RIBOSOMAL_S24E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS24A_YEAST
AccessioniPrimary (citable) accession number: P0CX31
Secondary accession number(s): D3DLX9, P26782
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 30, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 2 genes for S24 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.