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Protein

40S ribosomal protein S24-A

Gene

RPS24A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

There are 2 genes for eS24 in yeast.Curated

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-30245-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-SCE-72702 Ribosomal scanning and start codon recognition
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S24-A1 Publication
Alternative name(s):
RP50
Small ribosomal subunit protein eS24-A1 Publication
Gene namesi
Name:RPS24A1 Publication
Synonyms:RPS24EA
Ordered Locus Names:YER074W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome V

Organism-specific databases

SGDiS000000876 RPS24A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources2 Publications
ChainiPRO_00001376362 – 13540S ribosomal protein S24-AAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources2 Publications1
Modified residuei14PhosphoserineCombined sources1
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei56PhosphoserineCombined sources1

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA. Also partially acetylated by NatC.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP0CX31
PaxDbiP0CX31
PRIDEiP0CX31
TopDownProteomicsiP0CX31

PTM databases

CarbonylDBiP0CX31
iPTMnetiP0CX31

Expressioni

Gene expression databases

ExpressionAtlasiP0CX31 differential

Interactioni

Subunit structurei

Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi34923, 96 interactors
36817, 321 interactors
STRINGi4932.YIL069C

Structurei

Secondary structure

1135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 15Combined sources10
Turni16 – 19Combined sources4
Beta strandi20 – 28Combined sources9
Helixi37 – 48Combined sources12
Helixi52 – 54Combined sources3
Beta strandi55 – 62Combined sources8
Beta strandi69 – 78Combined sources10
Helixi79 – 85Combined sources7
Helixi88 – 93Combined sources6
Beta strandi95 – 97Combined sources3
Helixi105 – 116Combined sources12
Helixi123 – 134Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J16electron microscopy-D1-135[»]
3J6Xelectron microscopy6.10241-135[»]
3J6Yelectron microscopy6.10241-135[»]
3J77electron microscopy6.20241-135[»]
3J78electron microscopy6.30241-135[»]
4U3MX-ray3.00D4/d42-135[»]
4U3NX-ray3.20D4/d42-135[»]
4U3UX-ray2.90D4/d42-135[»]
4U4NX-ray3.10D4/d42-135[»]
4U4OX-ray3.60D4/d42-135[»]
4U4QX-ray3.00D4/d42-135[»]
4U4RX-ray2.80D4/d42-135[»]
4U4UX-ray3.00D4/d42-135[»]
4U4YX-ray3.20D4/d42-135[»]
4U4ZX-ray3.10D4/d42-135[»]
4U50X-ray3.20D4/d42-135[»]
4U51X-ray3.20D4/d42-135[»]
4U52X-ray3.00D4/d42-135[»]
4U53X-ray3.30D4/d42-135[»]
4U55X-ray3.20D4/d42-135[»]
4U56X-ray3.45D4/d42-135[»]
4U6FX-ray3.10D4/d42-135[»]
4V6Ielectron microscopy8.80AU1-135[»]
4V88X-ray3.00AY/CY1-135[»]
4V8Yelectron microscopy4.30AY1-135[»]
4V8Zelectron microscopy6.60AY1-135[»]
4V92electron microscopy3.70Y2-135[»]
5DATX-ray3.15D4/d42-135[»]
5DC3X-ray3.25D4/d42-135[»]
5DGEX-ray3.45D4/d42-135[»]
5DGFX-ray3.30D4/d42-135[»]
5DGVX-ray3.10D4/d42-135[»]
5FCIX-ray3.40D4/d42-135[»]
5FCJX-ray3.10D4/d42-135[»]
5I4LX-ray3.10D4/d42-135[»]
5JUOelectron microscopy4.00VB1-135[»]
5JUPelectron microscopy3.50VB1-135[»]
5JUSelectron microscopy4.20VB1-135[»]
5JUTelectron microscopy4.00VB1-135[»]
5JUUelectron microscopy4.00VB1-135[»]
5LL6electron microscopy3.90d1-135[»]
5LYBX-ray3.25D4/d42-135[»]
5M1Jelectron microscopy3.30Y22-135[»]
5MC6electron microscopy3.80d1-135[»]
5MEIX-ray3.50Z/d42-135[»]
5NDGX-ray3.70D4/d42-135[»]
5NDVX-ray3.30D4/d42-135[»]
5NDWX-ray3.70D4/d42-135[»]
5OBMX-ray3.40D4/d42-135[»]
5ON6X-ray3.10Z/d42-135[»]
5TBWX-ray3.00Z/d42-135[»]
5TGAX-ray3.30D4/d42-135[»]
5TGMX-ray3.50D4/d42-135[»]
5TZSelectron microscopy5.10F1-135[»]
5WLCelectron microscopy3.80LF1-135[»]
5WYJelectron microscopy8.70SZ1-135[»]
5WYKelectron microscopy4.50SZ1-135[»]
6EMLelectron microscopy3.60d1-135[»]
6FAIelectron microscopy3.40Y1-135[»]
ProteinModelPortaliP0CX31
SMRiP0CX31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000186306
InParanoidiP0CX31
KOiK02974
OMAiTHFGGGR
OrthoDBiEOG092C5MLH

Family and domain databases

HAMAPiMF_00545 Ribosomal_S24e, 1 hit
InterProiView protein in InterPro
IPR012678 Ribosomal_L23/L15e_core_dom_sf
IPR001976 Ribosomal_S24e
IPR018098 Ribosomal_S24e_CS
PANTHERiPTHR10496 PTHR10496, 1 hit
PfamiView protein in Pfam
PF01282 Ribosomal_S24e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006052 Ribosomal_S24e, 1 hit
SUPFAMiSSF54189 SSF54189, 1 hit
PROSITEiView protein in PROSITE
PS00529 RIBOSOMAL_S24E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CX31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAVTIRTR KVISNPLLAR KQFVVDVLHP NRANVSKDEL REKLAEVYKA
60 70 80 90 100
EKDAVSVFGF RTQFGGGKSV GFGLVYNSVA EAKKFEPTYR LVRYGLAEKV
110 120 130
EKASRQQRKQ KKNRDKKIFG TGKRLAKKVA RRNAD
Length:135
Mass (Da):15,329
Last modified:June 28, 2011 - v1
Checksum:i81B82D361207442A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16P → D AA sequence (PubMed:1544921).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18814 Genomic DNA Translation: AAB64613.1
BK006939 Genomic DNA Translation: DAA07733.1
PIRiS48410
RefSeqiNP_010997.3, NM_001178965.3
NP_012195.1, NM_001179419.1

Genome annotation databases

EnsemblFungiiYER074W; YER074W; YER074W
YIL069C; YIL069C; YIL069C
GeneIDi854741
856805
KEGGisce:YER074W
sce:YIL069C

Similar proteinsi

Entry informationi

Entry nameiRS24A_YEAST
AccessioniPrimary (citable) accession number: P0CX31
Secondary accession number(s): D3DLX9, P26782
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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