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P0CX29

- RS23A_YEAST

UniProt

P0CX29 - RS23A_YEAST

Protein

40S ribosomal protein S23-A

Gene

RPS23A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    2. regulation of translational fidelity Source: SGD
    3. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30825-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S23-A
    Alternative name(s):
    RP37
    S28
    YS14
    Gene namesi
    Name:RPS23A
    Synonyms:RPS28A
    Ordered Locus Names:YGR118W
    ORF Names:G6178
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR118w.
    SGDiS000003350. RPS23A.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosolic small ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi64 – 641P → A: Lethal mutation. 1 Publication
    Mutagenesisi65 – 651N → A: Lethal mutation. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14514540S ribosomal protein S23-APRO_0000146482Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei64 – 6413,4-dihydroxyproline1 Publication

    Post-translational modificationi

    Hydroxylation at Pro-64 affects translation termination efficiency. The stereochemistry of the 3,4-dihydroxyproline has not yet been determined.1 Publication

    Keywords - PTMi

    Hydroxylation

    Proteomic databases

    MaxQBiP0CX29.
    PRIDEiP0CX29.

    Interactioni

    Subunit structurei

    Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi33363. 92 interactions.
    36298. 23 interactions.

    Structurei

    Secondary structure

    1
    145
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi12 – 2312
    Helixi27 – 348
    Helixi36 – 394
    Beta strandi40 – 434
    Beta strandi45 – 5814
    Beta strandi71 – 766
    Turni77 – 793
    Beta strandi82 – 865
    Beta strandi89 – 913
    Helixi93 – 953
    Beta strandi101 – 1055
    Beta strandi108 – 1125
    Beta strandi115 – 1173
    Beta strandi122 – 1276
    Turni128 – 1303
    Helixi132 – 1376

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K5Xmodel-L28-145[»]
    1S1Helectron microscopy11.70L28-145[»]
    1VW9electron microscopy6.10Y1-145[»]
    1VWVelectron microscopy6.10Y1-145[»]
    3IZBelectron microscopy-L1-145[»]
    3JYVelectron microscopy8.90L28-145[»]
    3O2ZX-ray4.00P1-145[»]
    3O30X-ray4.00P1-145[»]
    3U5CX-ray3.00X1-145[»]
    3U5GX-ray3.00X1-145[»]
    4BYLelectron microscopy4.30X1-145[»]
    4BYTelectron microscopy6.60X1-145[»]
    4CUYelectron microscopy3.70X2-143[»]
    ProteinModelPortaliP0CX29.
    SMRiP0CX29. Positions 2-145.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0CX29.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S12P family.Curated

    Phylogenomic databases

    KOiK02973.
    OrthoDBiEOG7SN8R7.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR006032. Ribosomal_S12/S23.
    IPR005680. Ribosomal_S23_euk/arc.
    [Graphical view]
    PANTHERiPTHR11652. PTHR11652. 1 hit.
    PfamiPF00164. Ribosom_S12_S23. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
    SUPFAMiSSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00982. S23_S12_E_A. 1 hit.
    PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CX29-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKGKPRGLN SARKLRVHRR NNRWAENNYK KRLLGTAFKS SPFGGSSHAK    50
    GIVLEKLGIE SKQPNSAIRK CVRVQLIKNG KKVTAFVPND GCLNFVDEND 100
    EVLLAGFGRK GKAKGDIPGV RFKVVKVSGV SLLALWKEKK EKPRS 145
    Length:145
    Mass (Da):16,038
    Last modified:June 28, 2011 - v1
    Checksum:i5A89ADF540DA1311
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96570 Unassigned RNA. Translation: AAA16235.1.
    Z72903 Genomic DNA. Translation: CAA97128.1.
    BK006941 Genomic DNA. Translation: DAA08210.1.
    PIRiA46703.
    RefSeqiNP_011633.3. NM_001181247.3.
    NP_015457.1. NM_001184229.1.

    Genome annotation databases

    EnsemblFungiiYGR118W; YGR118W; YGR118W.
    YPR132W; YPR132W; YPR132W.
    GeneIDi853015.
    856250.
    KEGGisce:YGR118W.
    sce:YPR132W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M96570 Unassigned RNA. Translation: AAA16235.1 .
    Z72903 Genomic DNA. Translation: CAA97128.1 .
    BK006941 Genomic DNA. Translation: DAA08210.1 .
    PIRi A46703.
    RefSeqi NP_011633.3. NM_001181247.3.
    NP_015457.1. NM_001184229.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K5X model - L 28-145 [» ]
    1S1H electron microscopy 11.70 L 28-145 [» ]
    1VW9 electron microscopy 6.10 Y 1-145 [» ]
    1VWV electron microscopy 6.10 Y 1-145 [» ]
    3IZB electron microscopy - L 1-145 [» ]
    3JYV electron microscopy 8.90 L 28-145 [» ]
    3O2Z X-ray 4.00 P 1-145 [» ]
    3O30 X-ray 4.00 P 1-145 [» ]
    3U5C X-ray 3.00 X 1-145 [» ]
    3U5G X-ray 3.00 X 1-145 [» ]
    4BYL electron microscopy 4.30 X 1-145 [» ]
    4BYT electron microscopy 6.60 X 1-145 [» ]
    4CUY electron microscopy 3.70 X 2-143 [» ]
    ProteinModelPortali P0CX29.
    SMRi P0CX29. Positions 2-145.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33363. 92 interactions.
    36298. 23 interactions.

    Proteomic databases

    MaxQBi P0CX29.
    PRIDEi P0CX29.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR118W ; YGR118W ; YGR118W .
    YPR132W ; YPR132W ; YPR132W .
    GeneIDi 853015.
    856250.
    KEGGi sce:YGR118W.
    sce:YPR132W.

    Organism-specific databases

    CYGDi YGR118w.
    SGDi S000003350. RPS23A.

    Phylogenomic databases

    KOi K02973.
    OrthoDBi EOG7SN8R7.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30825-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    EvolutionaryTracei P0CX29.
    NextBioi 972878.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR006032. Ribosomal_S12/S23.
    IPR005680. Ribosomal_S23_euk/arc.
    [Graphical view ]
    PANTHERi PTHR11652. PTHR11652. 1 hit.
    Pfami PF00164. Ribosom_S12_S23. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002133. Ribosomal_S12/S23. 1 hit.
    SUPFAMi SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00982. S23_S12_E_A. 1 hit.
    PROSITEi PS00055. RIBOSOMAL_S12. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel cloning strategy reveals the gene for the yeast homologue to Escherichia coli ribosomal protein S12."
      Alksne L.E., Warner J.R.
      J. Biol. Chem. 268:10813-10819(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The sequence of a 23.4 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals CLB6, SPT6, RP28A and NUP57 genes, a Ty3 element and 11 new open reading frames."
      Hansen M., Albers M., Backes U., Coblenz A., Leuther H., Neu R., Schreer A., Schaefer B., Zimmermann M., Wolf K.
      Yeast 12:1273-1277(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: HYDROXYLATION AT PRO-64, MUTAGENESIS OF PRO-64 AND ASN-65.
    10. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
      Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
      Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 28-145, ELECTRON MICROSCOPY.
    11. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
      Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
      EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 28-145, ELECTRON MICROSCOPY.

    Entry informationi

    Entry nameiRS23A_YEAST
    AccessioniPrimary (citable) accession number: P0CX29
    Secondary accession number(s): D6VUP9, P32827
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 10600 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for S23 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3