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Protein

60S ribosomal protein L43-A

Gene

RPL43A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri39 – 60C4-typeAdd BLAST22

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-34199-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L43-A
Alternative name(s):
L37a
YL35
Gene namesi
Name:RPL43A
Ordered Locus Names:YPR043W
ORF Names:YP9499.02
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

SGDiS000006247. RPL43A.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001398382 – 9260S ribosomal protein L43-AAdd BLAST91

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP0CX25.
PRIDEiP0CX25.

PTM databases

iPTMnetiP0CX25.

Expressioni

Gene expression databases

ExpressionAtlasiP0CX25. baseline.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi33849. 46 interactors.
36220. 79 interactors.
MINTiMINT-2781587.

Structurei

Secondary structure

192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 14Combined sources6
Turni15 – 18Combined sources4
Helixi20 – 34Combined sources15
Turni40 – 42Combined sources3
Beta strandi44 – 49Combined sources6
Beta strandi54 – 57Combined sources4
Turni58 – 60Combined sources3
Beta strandi63 – 65Combined sources3
Beta strandi68 – 72Combined sources5
Helixi74 – 91Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-210-82[»]
3J6Xelectron microscopy6.10831-92[»]
3J6Yelectron microscopy6.10831-92[»]
3J77electron microscopy6.20931-92[»]
3J78electron microscopy6.30931-92[»]
3JCTelectron microscopy3.08p1-92[»]
4U3MX-ray3.00Q3/q32-92[»]
4U3NX-ray3.20Q3/q32-92[»]
4U3UX-ray2.90Q3/q32-92[»]
4U4NX-ray3.10Q3/q32-92[»]
4U4OX-ray3.60Q3/q32-92[»]
4U4QX-ray3.00Q3/q32-92[»]
4U4RX-ray2.80Q3/q32-92[»]
4U4UX-ray3.00Q3/q32-92[»]
4U4YX-ray3.20Q3/q32-92[»]
4U4ZX-ray3.10Q3/q32-92[»]
4U50X-ray3.20Q3/q32-92[»]
4U51X-ray3.20Q3/q32-92[»]
4U52X-ray3.00Q3/q32-92[»]
4U53X-ray3.30Q3/q32-92[»]
4U55X-ray3.20Q3/q32-92[»]
4U56X-ray3.45Q3/q32-92[»]
4U6FX-ray3.10Q3/q32-92[»]
4V4Belectron microscopy11.70B92-92[»]
4V6Ielectron microscopy8.80Bm1-92[»]
4V7Felectron microscopy8.70k1-92[»]
4V7RX-ray4.00Bg/Dg1-92[»]
4V88X-ray3.00Bp/Dp1-92[»]
4V8Telectron microscopy8.10p1-92[»]
4V91electron microscopy3.70p1-92[»]
5APNelectron microscopy3.91p1-92[»]
5APOelectron microscopy3.41p1-92[»]
5DATX-ray3.15Q3/q32-92[»]
5DC3X-ray3.25Q3/q32-92[»]
5FCIX-ray3.40Q3/q32-92[»]
5FCJX-ray3.10Q3/q32-92[»]
5FL8electron microscopy9.50p1-92[»]
5GAKelectron microscopy3.88D1-92[»]
5I4LX-ray3.10Q3/q32-92[»]
5JUOelectron microscopy4.00UA1-92[»]
5JUPelectron microscopy3.50UA1-92[»]
5JUSelectron microscopy4.20UA1-92[»]
5JUTelectron microscopy4.00UA1-92[»]
5JUUelectron microscopy4.00UA1-92[»]
ProteinModelPortaliP0CX25.
SMRiP0CX25.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CX25.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L37Ae family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri39 – 60C4-typeAdd BLAST22

Keywords - Domaini

Zinc-finger

Phylogenomic databases

InParanoidiP0CX25.
KOiK02921.
OrthoDBiEOG092C5X8P.

Family and domain databases

Gene3Di2.20.25.30. 1 hit.
HAMAPiMF_00327. Ribosomal_L37Ae. 1 hit.
InterProiIPR002674. Ribosomal_L37ae.
IPR011331. Ribosomal_L37ae/L37e.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PfamiPF01780. Ribosomal_L37ae. 1 hit.
[Graphical view]
SUPFAMiSSF57829. SSF57829. 1 hit.
TIGRFAMsiTIGR00280. eL43_euk_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CX25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRTKKVGI TGKYGVRYGS SLRRQVKKLE IQQHARYDCS FCGKKTVKRG
60 70 80 90
AAGIWTCSCC KKTVAGGAYT VSTAAAATVR STIRRLREMV EA
Length:92
Mass (Da):10,091
Last modified:June 28, 2011 - v1
Checksum:iE2057BF56B131730
GO

Mass spectrometryi

Molecular mass is 9953.311 Da from positions 2 - 92. Determined by ESI. Monoisotopic mass.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73616 Genomic DNA. Translation: CAA97993.1.
Z71255 Genomic DNA. Translation: CAA94991.1.
Z49219 Genomic DNA. Translation: CAA89164.1.
BK006949 Genomic DNA. Translation: DAA11468.1.
PIRiS54068.
RefSeqiNP_012628.3. NM_001181752.3.
NP_015368.1. NM_001184140.1.

Genome annotation databases

EnsemblFungiiYJR094W-A; YJR094W-A; YJR094W-A.
YPR043W; YPR043W; YPR043W.
GeneIDi853557.
856156.
KEGGisce:YJR094W-A.
sce:YPR043W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73616 Genomic DNA. Translation: CAA97993.1.
Z71255 Genomic DNA. Translation: CAA94991.1.
Z49219 Genomic DNA. Translation: CAA89164.1.
BK006949 Genomic DNA. Translation: DAA11468.1.
PIRiS54068.
RefSeqiNP_012628.3. NM_001181752.3.
NP_015368.1. NM_001184140.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-210-82[»]
3J6Xelectron microscopy6.10831-92[»]
3J6Yelectron microscopy6.10831-92[»]
3J77electron microscopy6.20931-92[»]
3J78electron microscopy6.30931-92[»]
3JCTelectron microscopy3.08p1-92[»]
4U3MX-ray3.00Q3/q32-92[»]
4U3NX-ray3.20Q3/q32-92[»]
4U3UX-ray2.90Q3/q32-92[»]
4U4NX-ray3.10Q3/q32-92[»]
4U4OX-ray3.60Q3/q32-92[»]
4U4QX-ray3.00Q3/q32-92[»]
4U4RX-ray2.80Q3/q32-92[»]
4U4UX-ray3.00Q3/q32-92[»]
4U4YX-ray3.20Q3/q32-92[»]
4U4ZX-ray3.10Q3/q32-92[»]
4U50X-ray3.20Q3/q32-92[»]
4U51X-ray3.20Q3/q32-92[»]
4U52X-ray3.00Q3/q32-92[»]
4U53X-ray3.30Q3/q32-92[»]
4U55X-ray3.20Q3/q32-92[»]
4U56X-ray3.45Q3/q32-92[»]
4U6FX-ray3.10Q3/q32-92[»]
4V4Belectron microscopy11.70B92-92[»]
4V6Ielectron microscopy8.80Bm1-92[»]
4V7Felectron microscopy8.70k1-92[»]
4V7RX-ray4.00Bg/Dg1-92[»]
4V88X-ray3.00Bp/Dp1-92[»]
4V8Telectron microscopy8.10p1-92[»]
4V91electron microscopy3.70p1-92[»]
5APNelectron microscopy3.91p1-92[»]
5APOelectron microscopy3.41p1-92[»]
5DATX-ray3.15Q3/q32-92[»]
5DC3X-ray3.25Q3/q32-92[»]
5FCIX-ray3.40Q3/q32-92[»]
5FCJX-ray3.10Q3/q32-92[»]
5FL8electron microscopy9.50p1-92[»]
5GAKelectron microscopy3.88D1-92[»]
5I4LX-ray3.10Q3/q32-92[»]
5JUOelectron microscopy4.00UA1-92[»]
5JUPelectron microscopy3.50UA1-92[»]
5JUSelectron microscopy4.20UA1-92[»]
5JUTelectron microscopy4.00UA1-92[»]
5JUUelectron microscopy4.00UA1-92[»]
ProteinModelPortaliP0CX25.
SMRiP0CX25.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33849. 46 interactors.
36220. 79 interactors.
MINTiMINT-2781587.

PTM databases

iPTMnetiP0CX25.

Proteomic databases

MaxQBiP0CX25.
PRIDEiP0CX25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJR094W-A; YJR094W-A; YJR094W-A.
YPR043W; YPR043W; YPR043W.
GeneIDi853557.
856156.
KEGGisce:YJR094W-A.
sce:YPR043W.

Organism-specific databases

SGDiS000006247. RPL43A.

Phylogenomic databases

InParanoidiP0CX25.
KOiK02921.
OrthoDBiEOG092C5X8P.

Enzyme and pathway databases

BioCyciYEAST:G3O-34199-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

EvolutionaryTraceiP0CX25.
PROiP0CX25.

Gene expression databases

ExpressionAtlasiP0CX25. baseline.

Family and domain databases

Gene3Di2.20.25.30. 1 hit.
HAMAPiMF_00327. Ribosomal_L37Ae. 1 hit.
InterProiIPR002674. Ribosomal_L37ae.
IPR011331. Ribosomal_L37ae/L37e.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PfamiPF01780. Ribosomal_L37ae. 1 hit.
[Graphical view]
SUPFAMiSSF57829. SSF57829. 1 hit.
TIGRFAMsiTIGR00280. eL43_euk_arch. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRL43A_YEAST
AccessioniPrimary (citable) accession number: P0CX25
Secondary accession number(s): D6VWR3, P49631
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 30, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 44600 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for L43 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.