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P0CX14

- YRF13_YEAST

UniProt

P0CX14 - YRF13_YEAST

Protein

Y' element ATP-dependent helicase protein 1 copy 3

Gene

YRF1-3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.1 Publication

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi874 – 8818ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA helicase activity Source: SGD
    3. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. DNA duplex unwinding Source: GOC
    2. telomere maintenance via recombination Source: SGD

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30952-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Y' element ATP-dependent helicase protein 1 copy 3 (EC:3.6.4.12)
    Gene namesi
    Name:YRF1-3
    Ordered Locus Names:YGR296W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGR296w.
    SGDiS000003528. YRF1-3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18591859Y' element ATP-dependent helicase protein 1 copy 3PRO_0000102203Add
    BLAST

    Proteomic databases

    MaxQBiP0CX14.

    Expressioni

    Inductioni

    Induced in absence of telomerase TLC1.1 Publication

    Interactioni

    Protein-protein interaction databases

    BioGridi33543. 5 interactions.
    35932. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP0CX14.
    SMRiP0CX14. Positions 963-1196.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini861 – 1038178Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini1095 – 1244150Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOGENOMiHOG000155528.
    OrthoDBiEOG7CNZS9.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 3 hits.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CX14-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIENEQICT CIAQILHLLN SLIITFLDDD KTETGQSFVY IDGFLVKKHN     50
    NQHTIVNFET YKNKMKVSDR RKFEKANFDE FESALNNKND LVHCPSITLF 100
    ESIPTEVRSF YEDEKSGLIK VVKFRTGAMD RKRSFEKIVV SVMVGKNVQK 150
    FLTFVEDEPD FQGGPIPSKY LIPKKINLMV YTLFQVHTLK FNRKDYDTLS 200
    LFYLNRGYYN ELSFRVLERC YEIASARPND SSTMRTFTDF VSGTPIVRGL 250
    QKSTIRKYGY NLAPYMFLLL HVDELSIFSA YQASLPGEKK VDTERLKRDL 300
    CPRKPTEIKY FSQICNDMMN KKDRLGDILH IILRACALNF GAGPRGGAGD 350
    EEDRSITNEE PIIPSVDEHG LKVCKLRSPN TPRRLRKTLD AVKALLVSSC 400
    ACTARDLDIF DDNNGVAMWK WIKILYHEVA QETALKDSYR ITLVPSSDGV 450
    SVCGKLFNRE YVRGFYFACK AQFDNLWEEL NDCFYMPTVV DIASLILRNR 500
    EVLFREPKRG IDEYLENDSF LQMIPVKYRE IVLPKLRRDT NKMTAALKNK 550
    VTVAIDELTV PLMWMIHFAV GYPYRYPELQ LLAFAGPQRN VYVDDTTRRI 600
    QLYTDYNKNG SSEPRLKTLD GLTSDYVFYF VTVLRQMQIC ALGNSYDAFN 650
    HDPWMDVVGF EDPDQVTNRD ISRIVLYSYM FLNTAKGCLV EYATFRQYMR 700
    ELPKNAPQKL NFREMRQGLI ALGRHCVGSR FETDLYESAT SELMANHSVQ 750
    TGRNIYGVDS FSLTSVSGTT ATLLQERASE RWIQWLGLES DYHCSFSSTR 800
    NAEDVVAGEA ASSDHHQKIS RVTRKRPREP KSTNDILVAG QKLFGSSFEF 850
    RDLHQLRLCH EIYMADTPSV AVQAPPGYGK TELFHLPLIA LASKGDVKYV 900
    SFLFVPYTVL LANCMIRLSR CGCLNVAPVR NFIEEGCDGV TDLYVGIYDD 950
    LASTNFTDRI AAWENIVECT FRTNNVKLGY LIVDEFHNFE TEVYRQSQFG 1000
    GITNLDFDAF EKAIFLSGTA PEAVADAALQ RIGLTGLAKK SMDINELKRS 1050
    EDLSRGLSSY PTRMFNLIKE KSEVPLGHVH KIWKKVESQP EEALKLLLAL 1100
    FEIEPESKAI VVASTTNEVE ELACSWRKYF RVVWIHGKLG AAEKVSRTKE 1150
    FVTDGSMRVL IGTKLVTEGI DIKQLMMVIM LDNRLNIIEL IQGVGRLRDG 1200
    GLCYLLSRKN SWAARNRKGE LPPIKEGCIT EQVREFYGLE SKKGKKGQHV 1250
    GCCGSRTDLS ADTVELIERM DRLAEKQATA SMSIVALPSS FQESNSSDRC 1300
    RKYCSSDEDS DTCIHGSANA STNATTNSST NATTTASTNV RTSATTTASI 1350
    NVRTSATTTE STNSSTNATT TASTNVRTSA TTTASINVRT SATTTESTNS 1400
    NTSATTTEST DSNTSATTTE STDSNTSATT TASTNSSTNA TTTASTNSST 1450
    NATTTESTNA SAKEDANKDG NAEDNRFHPV TDINKESYKR KGSQMVLLER 1500
    KKLKAQFPNT SENMNVLQFL GFRSDEIKHL FLYGIDVYFC PEGVFTQYGL 1550
    CKGCQKMFEL CVCWAGQKVS YRRMAWEALA VERMLRNDEE YKEYLEDIEP 1600
    YHGDPVGYLK YFSVKRGEIY SQIQRNYAWY LAITRRRETI SVLDSTRGKQ 1650
    GSQVFRMSGR QIKELYYKVW SNLRESKTEV LQYFLNWDEK KCREEWEAKD 1700
    DTVFVEALEK VGVFQRLRSM TSAGLQGPQY VKLQFSRHHR QLRSRYELSL 1750
    GMHLRDQLAL GVTPSKVPHW TAFLSMLIGL FCNKTFRQKL EYLLEQISEV 1800
    WLLPHWLDLA NVEVLAADNT RVPLYMLMVA VHKELDSDDV PDGRFDILLC 1850
    RDSSREVGE 1859
    Length:1,859
    Mass (Da):211,115
    Last modified:June 28, 2011 - v1
    Checksum:i65B3C19E1BFD40D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z73081 Genomic DNA. Translation: CAA97329.1.
    BK006941 Genomic DNA. Translation: DAA08381.1.
    PIRiS64633.
    RefSeqiNP_011812.3. NM_001181425.3.
    NP_015040.1. NM_001184097.1.

    Genome annotation databases

    EnsemblFungiiYGR296W; YGR296W; YGR296W.
    YPL283C; YPL283C; YPL283C.
    GeneIDi853213.
    855846.
    KEGGisce:YGR296W.
    sce:YPL283C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z73081 Genomic DNA. Translation: CAA97329.1 .
    BK006941 Genomic DNA. Translation: DAA08381.1 .
    PIRi S64633.
    RefSeqi NP_011812.3. NM_001181425.3.
    NP_015040.1. NM_001184097.1.

    3D structure databases

    ProteinModelPortali P0CX14.
    SMRi P0CX14. Positions 963-1196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33543. 5 interactions.
    35932. 4 interactions.

    Proteomic databases

    MaxQBi P0CX14.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGR296W ; YGR296W ; YGR296W .
    YPL283C ; YPL283C ; YPL283C .
    GeneIDi 853213.
    855846.
    KEGGi sce:YGR296W.
    sce:YPL283C.

    Organism-specific databases

    CYGDi YGR296w.
    SGDi S000003528. YRF1-3.

    Phylogenomic databases

    HOGENOMi HOG000155528.
    OrthoDBi EOG7CNZS9.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30952-MONOMER.

    Miscellaneous databases

    NextBioi 973401.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 3 hits.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase."
      Yamada M., Hayatsu N., Matsuura A., Ishikawa F.
      J. Biol. Chem. 273:33360-33366(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.

    Entry informationi

    Entry nameiYRF13_YEAST
    AccessioniPrimary (citable) accession number: P0CX14
    Secondary accession number(s): D6VV70, P53345, Q9UQW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3