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P0CX14

- YRF13_YEAST

UniProt

P0CX14 - YRF13_YEAST

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Protein

Y' element ATP-dependent helicase protein 1 copy 3

Gene

YRF1-3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi874 – 8818ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA helicase activity Source: SGD
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. DNA duplex unwinding Source: GOC
  2. telomere maintenance via recombination Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30952-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Y' element ATP-dependent helicase protein 1 copy 3 (EC:3.6.4.12)
Gene namesi
Name:YRF1-3
Ordered Locus Names:YGR296W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR296w.
SGDiS000003528. YRF1-3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18591859Y' element ATP-dependent helicase protein 1 copy 3PRO_0000102203Add
BLAST

Proteomic databases

MaxQBiP0CX14.

Expressioni

Inductioni

Induced in absence of telomerase TLC1.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi33543. 6 interactions.
35932. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliP0CX14.
SMRiP0CX14. Positions 963-1196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini861 – 1038178Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1095 – 1244150Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000155528.
OrthoDBiEOG7CNZS9.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CX14-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEIENEQICT CIAQILHLLN SLIITFLDDD KTETGQSFVY IDGFLVKKHN
60 70 80 90 100
NQHTIVNFET YKNKMKVSDR RKFEKANFDE FESALNNKND LVHCPSITLF
110 120 130 140 150
ESIPTEVRSF YEDEKSGLIK VVKFRTGAMD RKRSFEKIVV SVMVGKNVQK
160 170 180 190 200
FLTFVEDEPD FQGGPIPSKY LIPKKINLMV YTLFQVHTLK FNRKDYDTLS
210 220 230 240 250
LFYLNRGYYN ELSFRVLERC YEIASARPND SSTMRTFTDF VSGTPIVRGL
260 270 280 290 300
QKSTIRKYGY NLAPYMFLLL HVDELSIFSA YQASLPGEKK VDTERLKRDL
310 320 330 340 350
CPRKPTEIKY FSQICNDMMN KKDRLGDILH IILRACALNF GAGPRGGAGD
360 370 380 390 400
EEDRSITNEE PIIPSVDEHG LKVCKLRSPN TPRRLRKTLD AVKALLVSSC
410 420 430 440 450
ACTARDLDIF DDNNGVAMWK WIKILYHEVA QETALKDSYR ITLVPSSDGV
460 470 480 490 500
SVCGKLFNRE YVRGFYFACK AQFDNLWEEL NDCFYMPTVV DIASLILRNR
510 520 530 540 550
EVLFREPKRG IDEYLENDSF LQMIPVKYRE IVLPKLRRDT NKMTAALKNK
560 570 580 590 600
VTVAIDELTV PLMWMIHFAV GYPYRYPELQ LLAFAGPQRN VYVDDTTRRI
610 620 630 640 650
QLYTDYNKNG SSEPRLKTLD GLTSDYVFYF VTVLRQMQIC ALGNSYDAFN
660 670 680 690 700
HDPWMDVVGF EDPDQVTNRD ISRIVLYSYM FLNTAKGCLV EYATFRQYMR
710 720 730 740 750
ELPKNAPQKL NFREMRQGLI ALGRHCVGSR FETDLYESAT SELMANHSVQ
760 770 780 790 800
TGRNIYGVDS FSLTSVSGTT ATLLQERASE RWIQWLGLES DYHCSFSSTR
810 820 830 840 850
NAEDVVAGEA ASSDHHQKIS RVTRKRPREP KSTNDILVAG QKLFGSSFEF
860 870 880 890 900
RDLHQLRLCH EIYMADTPSV AVQAPPGYGK TELFHLPLIA LASKGDVKYV
910 920 930 940 950
SFLFVPYTVL LANCMIRLSR CGCLNVAPVR NFIEEGCDGV TDLYVGIYDD
960 970 980 990 1000
LASTNFTDRI AAWENIVECT FRTNNVKLGY LIVDEFHNFE TEVYRQSQFG
1010 1020 1030 1040 1050
GITNLDFDAF EKAIFLSGTA PEAVADAALQ RIGLTGLAKK SMDINELKRS
1060 1070 1080 1090 1100
EDLSRGLSSY PTRMFNLIKE KSEVPLGHVH KIWKKVESQP EEALKLLLAL
1110 1120 1130 1140 1150
FEIEPESKAI VVASTTNEVE ELACSWRKYF RVVWIHGKLG AAEKVSRTKE
1160 1170 1180 1190 1200
FVTDGSMRVL IGTKLVTEGI DIKQLMMVIM LDNRLNIIEL IQGVGRLRDG
1210 1220 1230 1240 1250
GLCYLLSRKN SWAARNRKGE LPPIKEGCIT EQVREFYGLE SKKGKKGQHV
1260 1270 1280 1290 1300
GCCGSRTDLS ADTVELIERM DRLAEKQATA SMSIVALPSS FQESNSSDRC
1310 1320 1330 1340 1350
RKYCSSDEDS DTCIHGSANA STNATTNSST NATTTASTNV RTSATTTASI
1360 1370 1380 1390 1400
NVRTSATTTE STNSSTNATT TASTNVRTSA TTTASINVRT SATTTESTNS
1410 1420 1430 1440 1450
NTSATTTEST DSNTSATTTE STDSNTSATT TASTNSSTNA TTTASTNSST
1460 1470 1480 1490 1500
NATTTESTNA SAKEDANKDG NAEDNRFHPV TDINKESYKR KGSQMVLLER
1510 1520 1530 1540 1550
KKLKAQFPNT SENMNVLQFL GFRSDEIKHL FLYGIDVYFC PEGVFTQYGL
1560 1570 1580 1590 1600
CKGCQKMFEL CVCWAGQKVS YRRMAWEALA VERMLRNDEE YKEYLEDIEP
1610 1620 1630 1640 1650
YHGDPVGYLK YFSVKRGEIY SQIQRNYAWY LAITRRRETI SVLDSTRGKQ
1660 1670 1680 1690 1700
GSQVFRMSGR QIKELYYKVW SNLRESKTEV LQYFLNWDEK KCREEWEAKD
1710 1720 1730 1740 1750
DTVFVEALEK VGVFQRLRSM TSAGLQGPQY VKLQFSRHHR QLRSRYELSL
1760 1770 1780 1790 1800
GMHLRDQLAL GVTPSKVPHW TAFLSMLIGL FCNKTFRQKL EYLLEQISEV
1810 1820 1830 1840 1850
WLLPHWLDLA NVEVLAADNT RVPLYMLMVA VHKELDSDDV PDGRFDILLC

RDSSREVGE
Length:1,859
Mass (Da):211,115
Last modified:June 28, 2011 - v1
Checksum:i65B3C19E1BFD40D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z73081 Genomic DNA. Translation: CAA97329.1.
BK006941 Genomic DNA. Translation: DAA08381.1.
PIRiS64633.
RefSeqiNP_011812.3. NM_001181425.3.
NP_015040.1. NM_001184097.1.

Genome annotation databases

EnsemblFungiiYGR296W; YGR296W; YGR296W.
YPL283C; YPL283C; YPL283C.
GeneIDi853213.
855846.
KEGGisce:YGR296W.
sce:YPL283C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z73081 Genomic DNA. Translation: CAA97329.1 .
BK006941 Genomic DNA. Translation: DAA08381.1 .
PIRi S64633.
RefSeqi NP_011812.3. NM_001181425.3.
NP_015040.1. NM_001184097.1.

3D structure databases

ProteinModelPortali P0CX14.
SMRi P0CX14. Positions 963-1196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33543. 6 interactions.
35932. 5 interactions.

Proteomic databases

MaxQBi P0CX14.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR296W ; YGR296W ; YGR296W .
YPL283C ; YPL283C ; YPL283C .
GeneIDi 853213.
855846.
KEGGi sce:YGR296W.
sce:YPL283C.

Organism-specific databases

CYGDi YGR296w.
SGDi S000003528. YRF1-3.

Phylogenomic databases

HOGENOMi HOG000155528.
OrthoDBi EOG7CNZS9.

Enzyme and pathway databases

BioCyci YEAST:G3O-30952-MONOMER.

Miscellaneous databases

NextBioi 973401.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase."
    Yamada M., Hayatsu N., Matsuura A., Ishikawa F.
    J. Biol. Chem. 273:33360-33366(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiYRF13_YEAST
AccessioniPrimary (citable) accession number: P0CX14
Secondary accession number(s): D6VV70, P53345, Q9UQW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3