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P0CX14

- YRF13_YEAST

UniProt

P0CX14 - YRF13_YEAST

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Protein
Y' element ATP-dependent helicase protein 1 copy 3
Gene
YRF1-3, YGR296W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi874 – 8818ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA helicase activity Source: SGD
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. DNA duplex unwinding Source: GOC
  2. telomere maintenance via recombination Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30952-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Y' element ATP-dependent helicase protein 1 copy 3 (EC:3.6.4.12)
Gene namesi
Name:YRF1-3
Ordered Locus Names:YGR296W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR296w.
SGDiS000003528. YRF1-3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18591859Y' element ATP-dependent helicase protein 1 copy 3
PRO_0000102203Add
BLAST

Proteomic databases

MaxQBiP0CX14.

Expressioni

Inductioni

Induced in absence of telomerase TLC1.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi33543. 5 interactions.
35932. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliP0CX14.
SMRiP0CX14. Positions 963-1196.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini861 – 1038178Helicase ATP-binding
Add
BLAST
Domaini1095 – 1244150Helicase C-terminal
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000155528.
OrthoDBiEOG7CNZS9.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CX14-1 [UniParc]FASTAAdd to Basket

« Hide

MEIENEQICT CIAQILHLLN SLIITFLDDD KTETGQSFVY IDGFLVKKHN     50
NQHTIVNFET YKNKMKVSDR RKFEKANFDE FESALNNKND LVHCPSITLF 100
ESIPTEVRSF YEDEKSGLIK VVKFRTGAMD RKRSFEKIVV SVMVGKNVQK 150
FLTFVEDEPD FQGGPIPSKY LIPKKINLMV YTLFQVHTLK FNRKDYDTLS 200
LFYLNRGYYN ELSFRVLERC YEIASARPND SSTMRTFTDF VSGTPIVRGL 250
QKSTIRKYGY NLAPYMFLLL HVDELSIFSA YQASLPGEKK VDTERLKRDL 300
CPRKPTEIKY FSQICNDMMN KKDRLGDILH IILRACALNF GAGPRGGAGD 350
EEDRSITNEE PIIPSVDEHG LKVCKLRSPN TPRRLRKTLD AVKALLVSSC 400
ACTARDLDIF DDNNGVAMWK WIKILYHEVA QETALKDSYR ITLVPSSDGV 450
SVCGKLFNRE YVRGFYFACK AQFDNLWEEL NDCFYMPTVV DIASLILRNR 500
EVLFREPKRG IDEYLENDSF LQMIPVKYRE IVLPKLRRDT NKMTAALKNK 550
VTVAIDELTV PLMWMIHFAV GYPYRYPELQ LLAFAGPQRN VYVDDTTRRI 600
QLYTDYNKNG SSEPRLKTLD GLTSDYVFYF VTVLRQMQIC ALGNSYDAFN 650
HDPWMDVVGF EDPDQVTNRD ISRIVLYSYM FLNTAKGCLV EYATFRQYMR 700
ELPKNAPQKL NFREMRQGLI ALGRHCVGSR FETDLYESAT SELMANHSVQ 750
TGRNIYGVDS FSLTSVSGTT ATLLQERASE RWIQWLGLES DYHCSFSSTR 800
NAEDVVAGEA ASSDHHQKIS RVTRKRPREP KSTNDILVAG QKLFGSSFEF 850
RDLHQLRLCH EIYMADTPSV AVQAPPGYGK TELFHLPLIA LASKGDVKYV 900
SFLFVPYTVL LANCMIRLSR CGCLNVAPVR NFIEEGCDGV TDLYVGIYDD 950
LASTNFTDRI AAWENIVECT FRTNNVKLGY LIVDEFHNFE TEVYRQSQFG 1000
GITNLDFDAF EKAIFLSGTA PEAVADAALQ RIGLTGLAKK SMDINELKRS 1050
EDLSRGLSSY PTRMFNLIKE KSEVPLGHVH KIWKKVESQP EEALKLLLAL 1100
FEIEPESKAI VVASTTNEVE ELACSWRKYF RVVWIHGKLG AAEKVSRTKE 1150
FVTDGSMRVL IGTKLVTEGI DIKQLMMVIM LDNRLNIIEL IQGVGRLRDG 1200
GLCYLLSRKN SWAARNRKGE LPPIKEGCIT EQVREFYGLE SKKGKKGQHV 1250
GCCGSRTDLS ADTVELIERM DRLAEKQATA SMSIVALPSS FQESNSSDRC 1300
RKYCSSDEDS DTCIHGSANA STNATTNSST NATTTASTNV RTSATTTASI 1350
NVRTSATTTE STNSSTNATT TASTNVRTSA TTTASINVRT SATTTESTNS 1400
NTSATTTEST DSNTSATTTE STDSNTSATT TASTNSSTNA TTTASTNSST 1450
NATTTESTNA SAKEDANKDG NAEDNRFHPV TDINKESYKR KGSQMVLLER 1500
KKLKAQFPNT SENMNVLQFL GFRSDEIKHL FLYGIDVYFC PEGVFTQYGL 1550
CKGCQKMFEL CVCWAGQKVS YRRMAWEALA VERMLRNDEE YKEYLEDIEP 1600
YHGDPVGYLK YFSVKRGEIY SQIQRNYAWY LAITRRRETI SVLDSTRGKQ 1650
GSQVFRMSGR QIKELYYKVW SNLRESKTEV LQYFLNWDEK KCREEWEAKD 1700
DTVFVEALEK VGVFQRLRSM TSAGLQGPQY VKLQFSRHHR QLRSRYELSL 1750
GMHLRDQLAL GVTPSKVPHW TAFLSMLIGL FCNKTFRQKL EYLLEQISEV 1800
WLLPHWLDLA NVEVLAADNT RVPLYMLMVA VHKELDSDDV PDGRFDILLC 1850
RDSSREVGE 1859
Length:1,859
Mass (Da):211,115
Last modified:June 28, 2011 - v1
Checksum:i65B3C19E1BFD40D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z73081 Genomic DNA. Translation: CAA97329.1.
BK006941 Genomic DNA. Translation: DAA08381.1.
PIRiS64633.
RefSeqiNP_011812.3. NM_001181425.3.
NP_015040.1. NM_001184097.1.

Genome annotation databases

EnsemblFungiiYGR296W; YGR296W; YGR296W.
YPL283C; YPL283C; YPL283C.
GeneIDi853213.
855846.
KEGGisce:YGR296W.
sce:YPL283C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z73081 Genomic DNA. Translation: CAA97329.1 .
BK006941 Genomic DNA. Translation: DAA08381.1 .
PIRi S64633.
RefSeqi NP_011812.3. NM_001181425.3.
NP_015040.1. NM_001184097.1.

3D structure databases

ProteinModelPortali P0CX14.
SMRi P0CX14. Positions 963-1196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33543. 5 interactions.
35932. 4 interactions.

Proteomic databases

MaxQBi P0CX14.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR296W ; YGR296W ; YGR296W .
YPL283C ; YPL283C ; YPL283C .
GeneIDi 853213.
855846.
KEGGi sce:YGR296W.
sce:YPL283C.

Organism-specific databases

CYGDi YGR296w.
SGDi S000003528. YRF1-3.

Phylogenomic databases

HOGENOMi HOG000155528.
OrthoDBi EOG7CNZS9.

Enzyme and pathway databases

BioCyci YEAST:G3O-30952-MONOMER.

Miscellaneous databases

NextBioi 973401.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase."
    Yamada M., Hayatsu N., Matsuura A., Ishikawa F.
    J. Biol. Chem. 273:33360-33366(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiYRF13_YEAST
AccessioniPrimary (citable) accession number: P0CX14
Secondary accession number(s): D6VV70, P53345, Q9UQW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

Similar proteinsi