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Protein

Protein COS2

Gene

COS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyciYEAST:G3O-29218-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein COS2
Gene namesi
Name:COS2
Ordered Locus Names:YBR302C
ORF Names:YBR2121
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

SGDiS000000506. COS2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 72CytoplasmicSequence analysisAdd BLAST72
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 254ExtracellularSequence analysisAdd BLAST161
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 379CytoplasmicSequence analysisAdd BLAST104

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075141 – 379Protein COS2Add BLAST379

Proteomic databases

MaxQBiP0CX12.
PRIDEiP0CX12.

Interactioni

Protein-protein interaction databases

BioGridi32994. 1 interactor.
35073. 12 interactors.
STRINGi4932.YML132W.

Structurei

3D structure databases

ProteinModelPortaliP0CX12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DUP/COS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000000864.
InParanoidiP0CX12.
OMAiEMFATLV.
OrthoDBiEOG092C1A2Q.

Family and domain databases

InterProiView protein in InterPro
IPR001142. DUP/COS.
PfamiView protein in Pfam
PF00674. DUP. 2 hits.

Sequencei

Sequence statusi: Complete.

P0CX12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR
60 70 80 90 100
IWMLLWLPLS VWWKLSNNCI YPLIVSLLVL FLGPIFVLVI CGLSRKRSLS
110 120 130 140 150
KQLIQFCKEI TENTPSSDPH DWEVVAANLN SYLYENNVWN TKYFFFNAMV
160 170 180 190 200
CQEAFRTTLL EPFSLKKDKA AKVKSFKDSV PYIEEALGVY FTEVEKQWKL
210 220 230 240 250
FNTEKSWSPV GLEDAKLPKE AYRFKLTWFL KRISNIFMLI PFLNFLCCIY
260 270 280 290 300
VSRGMCLLLR TLYLGWILFM LVQGFQNIRV LIMSMEHKMQ FLSTIINEQE
310 320 330 340 350
SGANGWDEIA RKMNRYLFEK KAWKNEEFFF DGIDCEWFFN HFFYRVLSAK
360 370
KSMWPLPLNV ELWPYIKEAQ LSRSEVLLV
Length:379
Mass (Da):45,165
Last modified:June 28, 2011 - v1
Checksum:i2AAB51B6C103AF61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36171 Genomic DNA. Translation: CAA85267.1.
BK006936 Genomic DNA. Translation: DAA07417.1.
PIRiS46187.
RefSeqiNP_009861.1. NM_001178650.1.
NP_013574.1. NM_001182495.1.

Genome annotation databases

EnsemblFungiiYBR302C; YBR302C; YBR302C.
YML132W; YML132W; YML132W.
GeneIDi852605.
854907.
KEGGisce:YBR302C.
sce:YML132W.

Similar proteinsi

Entry informationi

Entry nameiCOS2_YEAST
AccessioniPrimary (citable) accession number: P0CX12
Secondary accession number(s): D6VQU7, P38363
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 27, 2017
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names