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P0CX12

- COS2_YEAST

UniProt

P0CX12 - COS2_YEAST

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Protein

Protein COS2

Gene

COS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-29218-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein COS2
Gene namesi
Name:COS2
Ordered Locus Names:YBR302C
ORF Names:YBR2121
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR302c.
SGDiS000000506. COS2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Protein COS2PRO_0000207514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki18 – 18Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki205 – 205Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP0CX12.

Interactioni

Protein-protein interaction databases

BioGridi32994. 2 interactions.
35073. 12 interactions.

Structurei

3D structure databases

ProteinModelPortaliP0CX12.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7272CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini94 – 254161ExtracellularSequence AnalysisAdd
BLAST
Topological domaini276 – 379104CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the DUP/COS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000000864.
InParanoidiP0CX12.
OrthoDBiEOG74TX82.

Family and domain databases

InterProiIPR001142. DUP.
[Graphical view]
PfamiPF00674. DUP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CX12-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR
60 70 80 90 100
IWMLLWLPLS VWWKLSNNCI YPLIVSLLVL FLGPIFVLVI CGLSRKRSLS
110 120 130 140 150
KQLIQFCKEI TENTPSSDPH DWEVVAANLN SYLYENNVWN TKYFFFNAMV
160 170 180 190 200
CQEAFRTTLL EPFSLKKDKA AKVKSFKDSV PYIEEALGVY FTEVEKQWKL
210 220 230 240 250
FNTEKSWSPV GLEDAKLPKE AYRFKLTWFL KRISNIFMLI PFLNFLCCIY
260 270 280 290 300
VSRGMCLLLR TLYLGWILFM LVQGFQNIRV LIMSMEHKMQ FLSTIINEQE
310 320 330 340 350
SGANGWDEIA RKMNRYLFEK KAWKNEEFFF DGIDCEWFFN HFFYRVLSAK
360 370
KSMWPLPLNV ELWPYIKEAQ LSRSEVLLV
Length:379
Mass (Da):45,165
Last modified:June 28, 2011 - v1
Checksum:i2AAB51B6C103AF61
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36171 Genomic DNA. Translation: CAA85267.1.
BK006936 Genomic DNA. Translation: DAA07417.1.
PIRiS46187.
RefSeqiNP_009861.1. NM_001178650.1.
NP_013574.1. NM_001182495.1.

Genome annotation databases

EnsemblFungiiYBR302C; YBR302C; YBR302C.
YML132W; YML132W; YML132W.
GeneIDi852605.
854907.
KEGGisce:YBR302C.
sce:YML132W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36171 Genomic DNA. Translation: CAA85267.1 .
BK006936 Genomic DNA. Translation: DAA07417.1 .
PIRi S46187.
RefSeqi NP_009861.1. NM_001178650.1.
NP_013574.1. NM_001182495.1.

3D structure databases

ProteinModelPortali P0CX12.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32994. 2 interactions.
35073. 12 interactions.

Proteomic databases

MaxQBi P0CX12.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR302C ; YBR302C ; YBR302C .
YML132W ; YML132W ; YML132W .
GeneIDi 852605.
854907.
KEGGi sce:YBR302C.
sce:YML132W.

Organism-specific databases

CYGDi YBR302c.
SGDi S000000506. COS2.

Phylogenomic databases

HOGENOMi HOG000000864.
InParanoidi P0CX12.
OrthoDBi EOG74TX82.

Enzyme and pathway databases

BioCyci YEAST:G3O-29218-MONOMER.

Miscellaneous databases

NextBioi 971790.

Family and domain databases

InterProi IPR001142. DUP.
[Graphical view ]
Pfami PF00674. DUP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery."
    Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.
    Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-18 AND LYS-205.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiCOS2_YEAST
AccessioniPrimary (citable) accession number: P0CX12
Secondary accession number(s): D6VQU7, P38363
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3