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Protein

Probable C-mannosyltransferase DPY19L2

Gene

Dpy19l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Required during spermatogenesis for sperm head elongation and acrosome formation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: UniProtKB-KW
  • spermatid development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Glycosyltransferase, Transferase

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C-mannosyltransferase DPY19L2 (EC:2.4.1.-)
Alternative name(s):
Dpy-19-like protein 2
Protein dpy-19 homolog 2
Gene namesi
Name:Dpy19l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2444662. Dpy19l2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei123 – 14321HelicalSequence analysisAdd
BLAST
Transmembranei210 – 23021HelicalSequence analysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence analysisAdd
BLAST
Transmembranei312 – 33221HelicalSequence analysisAdd
BLAST
Transmembranei345 – 36723HelicalSequence analysisAdd
BLAST
Transmembranei387 – 40721HelicalSequence analysisAdd
BLAST
Transmembranei438 – 45821HelicalSequence analysisAdd
BLAST
Transmembranei508 – 52821HelicalSequence analysisAdd
BLAST
Transmembranei549 – 56921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • nuclear inner membrane Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 773773Probable C-mannosyltransferase DPY19L2PRO_0000408327Add
BLAST

Proteomic databases

PaxDbiP0CW70.
PRIDEiP0CW70.

Expressioni

Tissue specificityi

Predominantly expressed in testis. Present in testis but absent from epididymal sperm (at protein level).1 Publication

Gene expression databases

BgeeiP0CW70.
GenevisibleiP0CW70. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000132092.

Structurei

3D structure databases

ProteinModelPortaliP0CW70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dpy-19 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4587. Eukaryota.
ENOG410XRWN. LUCA.
GeneTreeiENSGT00530000063023.
InParanoidiP0CW70.
OMAiLQMYVLT.
OrthoDBiEOG7N37BZ.
PhylomeDBiP0CW70.
TreeFamiTF313376.

Family and domain databases

InterProiIPR018732. Dpy-19/Dpy-19-like.
IPR030042. DPY19L2.
[Graphical view]
PANTHERiPTHR31488. PTHR31488. 1 hit.
PTHR31488:SF6. PTHR31488:SF6. 1 hit.
PfamiPF10034. Dpy19. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CW70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGPTRSKLR EGSSDRPQSS CTGQARRRWS AATMEPQQER SAPQERTKWS
60 70 80 90 100
LLQHFLLGGR KLPSGARNYA ARRIQSLNAQ NYFQLEEVAK LLLLNRFQFL
110 120 130 140 150
FTLLDHFREK VQALQMHRFS HRTLFGLAIF VGILHWLHLI TLFENDHHFS
160 170 180 190 200
HLSSLEREMT FRTEMGLYYS YFKTIIEAPS FLEGLWMIMN DRLTEYPLVI
210 220 230 240 250
NTVKRFHLYP EVVIAYWYRT IIGIMNLFGI ETKTCWNVTR MEPLNEVQSC
260 270 280 290 300
EGLGDPACFY IGVIFILNGL MMGLFFIYST YLSGSQLGGL ITVACYFFNH
310 320 330 340 350
GEATRVMWTP PLRESFSYPF LVLQMYILTI ILRTSTVHKK HYMALCFSNV
360 370 380 390 400
AFMLPWQFAQ FILFTQIASL FPMYVVGYIE PSKFQKIIYV NMSSVALCFI
410 420 430 440 450
LMFGNSMYLS SYYSSCLLVT WAIMQKKSKI QKLGGTELQF WLIQGCFWWC
460 470 480 490 500
GTIILKFLTS KICGVSDHIR LSDLIAARIL RYTDFDTLIY TCAPEFDFME
510 520 530 540 550
QATPLRYIKT LLLPLILVIT YLIFKKIVRD IMCVLYTNTY VRKQLLDNAE
560 570 580 590 600
LIFHTLQLLA FTGLAILIMR LKLFLTPHMC IMASLICSQR LFGWLFCRIH
610 620 630 640 650
FENVVFGILT MMSIQGCANL HNQWSIMGEF TNLPQEELIH WIKHSTRPDA
660 670 680 690 700
VFAGAMPTMA SIKLSTLRPI VNHPHYEDAD LRARTKIVYS VYSRKSAVEV
710 720 730 740 750
RNNLLKLHVN YYVLEEAWCV VRTKPGCSML EIWDVEDPSN AANPPLCSIL
760 770
LKDSRPYFTT VFQNSMYRVL KIN
Length:773
Mass (Da):89,882
Last modified:May 3, 2011 - v1
Checksum:i72BE45D2458E68C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154463 Genomic DNA. No translation available.
CT025664 Genomic DNA. No translation available.
CCDSiCCDS52743.1.
RefSeqiNP_001159679.1. NM_001166207.1.
UniGeneiMm.46158.

Genome annotation databases

EnsembliENSMUST00000133010; ENSMUSP00000132092; ENSMUSG00000085576.
GeneIDi320752.
KEGGimmu:320752.
UCSCiuc009opc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154463 Genomic DNA. No translation available.
CT025664 Genomic DNA. No translation available.
CCDSiCCDS52743.1.
RefSeqiNP_001159679.1. NM_001166207.1.
UniGeneiMm.46158.

3D structure databases

ProteinModelPortaliP0CW70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000132092.

Proteomic databases

PaxDbiP0CW70.
PRIDEiP0CW70.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000133010; ENSMUSP00000132092; ENSMUSG00000085576.
GeneIDi320752.
KEGGimmu:320752.
UCSCiuc009opc.2. mouse.

Organism-specific databases

CTDi283417.
MGIiMGI:2444662. Dpy19l2.

Phylogenomic databases

eggNOGiKOG4587. Eukaryota.
ENOG410XRWN. LUCA.
GeneTreeiENSGT00530000063023.
InParanoidiP0CW70.
OMAiLQMYVLT.
OrthoDBiEOG7N37BZ.
PhylomeDBiP0CW70.
TreeFamiTF313376.

Miscellaneous databases

NextBioi397369.
PROiP0CW70.
SOURCEiSearch...

Gene expression databases

BgeeiP0CW70.
GenevisibleiP0CW70. MM.

Family and domain databases

InterProiIPR018732. Dpy-19/Dpy-19-like.
IPR030042. DPY19L2.
[Graphical view]
PANTHERiPTHR31488. PTHR31488. 1 hit.
PTHR31488:SF6. PTHR31488:SF6. 1 hit.
PfamiPF10034. Dpy19. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiD19L2_MOUSE
AccessioniPrimary (citable) accession number: P0CW70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 11, 2016
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.