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Protein

DNA repair and recombination protein RadA

Gene

radA

Organism
Methanococcus maripaludis (Methanococcus deltae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi105 – 1128ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.4.B7. 3262.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair and recombination protein RadAUniRule annotation
Gene namesi
Name:radAUniRule annotation
OrganismiMethanococcus maripaludis (Methanococcus deltae)
Taxonomic identifieri39152 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322DNA repair and recombination protein RadAPRO_0000150097Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402880.MmarC5_0368.

Structurei

Secondary structure

1
322
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 73Combined sources
Helixi13 – 219Combined sources
Helixi27 – 315Combined sources
Helixi35 – 395Combined sources
Helixi46 – 5914Combined sources
Helixi68 – 747Combined sources
Helixi85 – 906Combined sources
Turni91 – 933Combined sources
Beta strandi94 – 963Combined sources
Beta strandi99 – 1068Combined sources
Helixi111 – 12212Combined sources
Helixi125 – 1273Combined sources
Turni132 – 1343Combined sources
Helixi137 – 1393Combined sources
Beta strandi140 – 15213Combined sources
Helixi156 – 16611Combined sources
Helixi170 – 1756Combined sources
Beta strandi177 – 1815Combined sources
Helixi185 – 20016Combined sources
Beta strandi204 – 21411Combined sources
Helixi215 – 2206Combined sources
Helixi224 – 2263Combined sources
Helixi227 – 24721Combined sources
Beta strandi251 – 2566Combined sources
Beta strandi258 – 2603Combined sources
Beta strandi270 – 2745Combined sources
Helixi275 – 2817Combined sources
Beta strandi283 – 2908Combined sources
Beta strandi295 – 3028Combined sources
Beta strandi304 – 3063Combined sources
Beta strandi309 – 3157Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ETLX-ray2.40A1-322[»]
3EW9X-ray2.40A1-322[»]
3EWAX-ray2.00A1-322[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CW58.

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic RecA-like protein family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00415. Archaea.
COG0468. LUCA.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00348. RadA_arch.
InterProiIPR003593. AAA+_ATPase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR011938. DNA_recomb/repair_RadA.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02236. recomb_radA. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CW58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVLTELPG VGPSTADKLI EGGYLDFMKI ATATIGELTD IEGISEKAAA
60 70 80 90 100
KMIMAARDLC DLGFKSGVEL LKQRQSVWRL STGSTELGTV LAGGIESQSV
110 120 130 140 150
TEFAGMFGSG KTQIMHQTCV NLQMREKIFA DLEGVVEEEL EAPKAVYIDT
160 170 180 190 200
EGTFRPERVV QMAEGAGIDG QTVLDNTFVA RAYNSDMQML FAEKIEDLIK
210 220 230 240 250
GGNNIKLVII DSLTSTFRNE FTGRGKLAER QQKLGRHMAT LNKLADLYNC
260 270 280 290 300
IVLVTNQVAA KPDAYFGVAE QAIGGHVVGH AATFRFFLRK SKGDKRVAKL
310 320
YDSPHLPDSE AVFRITEKGI QD
Length:322
Mass (Da):35,106
Last modified:May 3, 2011 - v1
Checksum:i2FE5E2D3064E66DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322003 Genomic DNA. Translation: AAL26913.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322003 Genomic DNA. Translation: AAL26913.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ETLX-ray2.40A1-322[»]
3EW9X-ray2.40A1-322[»]
3EWAX-ray2.00A1-322[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402880.MmarC5_0368.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiarCOG00415. Archaea.
COG0468. LUCA.

Enzyme and pathway databases

BRENDAi3.6.4.B7. 3262.

Miscellaneous databases

EvolutionaryTraceiP0CW58.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00348. RadA_arch.
InterProiIPR003593. AAA+_ATPase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR011938. DNA_recomb/repair_RadA.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02236. recomb_radA. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Archaeal RecA homologs: different response to DNA damaging agents in mesophilic and thermophilic Archaea."
    Reich C.I., McNeil L.K., Brace J.L., Brucker J.K., Olsen G.J.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43000 / DSM 2067 / JCM 10722 / JJ.

Entry informationi

Entry nameiRADA_METMI
AccessioniPrimary (citable) accession number: P0CW58
Secondary accession number(s): Q977P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 3, 2011
Last modified: April 13, 2016
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.