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Protein

DNA repair and recombination protein RadA

Gene

radA

Organism
Methanococcus maripaludis (Methanococcus deltae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi105 – 112ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.4.B7. 3262.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair and recombination protein RadAUniRule annotation
Gene namesi
Name:radAUniRule annotation
OrganismiMethanococcus maripaludis (Methanococcus deltae)
Taxonomic identifieri39152 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001500971 – 322DNA repair and recombination protein RadAAdd BLAST322

Interactioni

Protein-protein interaction databases

STRINGi402880.MmarC5_0368.

Structurei

Secondary structure

1322
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 7Combined sources3
Helixi13 – 21Combined sources9
Helixi27 – 31Combined sources5
Helixi35 – 39Combined sources5
Helixi46 – 59Combined sources14
Helixi68 – 74Combined sources7
Helixi85 – 90Combined sources6
Turni91 – 93Combined sources3
Beta strandi94 – 96Combined sources3
Beta strandi99 – 106Combined sources8
Helixi111 – 122Combined sources12
Helixi125 – 127Combined sources3
Turni132 – 134Combined sources3
Helixi137 – 139Combined sources3
Beta strandi140 – 152Combined sources13
Helixi156 – 166Combined sources11
Helixi170 – 175Combined sources6
Beta strandi177 – 181Combined sources5
Helixi185 – 200Combined sources16
Beta strandi204 – 214Combined sources11
Helixi215 – 220Combined sources6
Helixi224 – 226Combined sources3
Helixi227 – 247Combined sources21
Beta strandi251 – 256Combined sources6
Beta strandi258 – 260Combined sources3
Beta strandi270 – 274Combined sources5
Helixi275 – 281Combined sources7
Beta strandi283 – 290Combined sources8
Beta strandi295 – 302Combined sources8
Beta strandi304 – 306Combined sources3
Beta strandi309 – 315Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ETLX-ray2.40A1-322[»]
3EW9X-ray2.40A1-322[»]
3EWAX-ray2.00A1-322[»]
SMRiP0CW58.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CW58.

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic RecA-like protein family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00415. Archaea.
COG0468. LUCA.

Family and domain databases

CDDicd01123. Rad51_DMC1_radA. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00348. RadA_arch. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR011938. DNA_recomb/repair_RadA.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR027417. P-loop_NTPase.
IPR033925. Rad51_DMC1_RadA.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02236. recomb_radA. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CW58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVLTELPG VGPSTADKLI EGGYLDFMKI ATATIGELTD IEGISEKAAA
60 70 80 90 100
KMIMAARDLC DLGFKSGVEL LKQRQSVWRL STGSTELGTV LAGGIESQSV
110 120 130 140 150
TEFAGMFGSG KTQIMHQTCV NLQMREKIFA DLEGVVEEEL EAPKAVYIDT
160 170 180 190 200
EGTFRPERVV QMAEGAGIDG QTVLDNTFVA RAYNSDMQML FAEKIEDLIK
210 220 230 240 250
GGNNIKLVII DSLTSTFRNE FTGRGKLAER QQKLGRHMAT LNKLADLYNC
260 270 280 290 300
IVLVTNQVAA KPDAYFGVAE QAIGGHVVGH AATFRFFLRK SKGDKRVAKL
310 320
YDSPHLPDSE AVFRITEKGI QD
Length:322
Mass (Da):35,106
Last modified:May 3, 2011 - v1
Checksum:i2FE5E2D3064E66DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322003 Genomic DNA. Translation: AAL26913.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322003 Genomic DNA. Translation: AAL26913.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ETLX-ray2.40A1-322[»]
3EW9X-ray2.40A1-322[»]
3EWAX-ray2.00A1-322[»]
SMRiP0CW58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402880.MmarC5_0368.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiarCOG00415. Archaea.
COG0468. LUCA.

Enzyme and pathway databases

BRENDAi3.6.4.B7. 3262.

Miscellaneous databases

EvolutionaryTraceiP0CW58.

Family and domain databases

CDDicd01123. Rad51_DMC1_radA. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00348. RadA_arch. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR011938. DNA_recomb/repair_RadA.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR027417. P-loop_NTPase.
IPR033925. Rad51_DMC1_RadA.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02236. recomb_radA. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRADA_METMI
AccessioniPrimary (citable) accession number: P0CW58
Secondary accession number(s): Q977P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 3, 2011
Last modified: November 30, 2016
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.