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Protein

A-kinase anchor protein inhibitor 1

Gene

AKAIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A-kinase anchoring protein (AKAP)-mediated subcellular localization of PKA (PubMed:25653177).1 Publication

GO - Molecular functioni

  • protein kinase A binding Source: UniProtKB
  • protein kinase A regulatory subunit binding Source: GO_Central

GO - Biological processi

  • protein localization Source: UniProtKB
  • regulation of protein kinase A signaling Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein inhibitor 1
Gene namesi
Name:AKAIN1Imported
Synonyms:C18orf42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000231824.3
HGNCiHGNC:28285 AKAIN1
MIMi616427 gene
neXtProtiNX_P0CW23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi25I → P: Reduces binding to RII subunits of PKA. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000231824

Polymorphism and mutation databases

BioMutaiC18orf42
DMDMi338817804

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004107711 – 69A-kinase anchor protein inhibitor 1Add BLAST69

Proteomic databases

PaxDbiP0CW23
PeptideAtlasiP0CW23
PRIDEiP0CW23

Expressioni

Tissue specificityi

Preferentially expressed in the neural tissues (PubMed:25653177).1 Publication

Gene expression databases

BgeeiENSG00000231824
ExpressionAtlasiP0CW23 baseline and differential

Organism-specific databases

HPAiHPA049365

Interactioni

Subunit structurei

Binds cAMP-dependent protein kinase (PKA). Interacts specifically with RII-regulatory subunits of PKA (PRKAR2A and PRKAR2B) (PubMed:25653177).1 Publication

GO - Molecular functioni

  • protein kinase A binding Source: UniProtKB
  • protein kinase A regulatory subunit binding Source: GO_Central

Structurei

3D structure databases

ProteinModelPortaliP0CW23
SMRiP0CW23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 33PKA-RII subunit binding domainCuratedAdd BLAST17

Domaini

The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Phylogenomic databases

eggNOGiENOG410JF47 Eukaryota
ENOG411135H LUCA
GeneTreeiENSGT00560000078638
InParanoidiP0CW23
PhylomeDBiP0CW23

Family and domain databases

InterProiView protein in InterPro
IPR019511 AKAP7_RI-RII-bd_dom
PfamiView protein in Pfam
PF10470 AKAP7_RIRII_bdg, 1 hit

Sequencei

Sequence statusi: Complete.

P0CW23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFAPGEKPG NEPEEVKLQN ASKQIVQNAI LQAVQQVSQE SQRREERISD
60
NRDHIQLGVG ELTKKHEKK
Length:69
Mass (Da):7,848
Last modified:June 28, 2011 - v1
Checksum:iBB4ED950347AD8C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DA365827 mRNA No translation available.
AP001496 Genomic DNA No translation available.
AP005380 Genomic DNA No translation available.
CCDSiCCDS54179.1
RefSeqiNP_001138666.1, NM_001145194.1
UniGeneiHs.437160

Genome annotation databases

EnsembliENST00000434239; ENSP00000399075; ENSG00000231824
GeneIDi642597
KEGGihsa:642597
UCSCiuc010wzc.2 human

Similar proteinsi

Entry informationi

Entry nameiAKAI1_HUMAN
AccessioniPrimary (citable) accession number: P0CW23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: February 28, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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