Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

A-kinase anchor protein inhibitor 1

Gene

AKAIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A-kinase anchoring protein (AKAP)-mediated subcellular localization of PKA (PubMed:25653177).1 Publication

GO - Molecular functioni

  • protein kinase A binding Source: UniProtKB
  • protein kinase A regulatory subunit binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein inhibitor 1
Gene namesi
Name:AKAIN1Imported
Synonyms:C18orf42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:28285. AKAIN1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi25I → P: Reduces binding to RII subunits of PKA. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000231824.

Polymorphism and mutation databases

BioMutaiC18orf42.
DMDMi338817804.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004107711 – 69A-kinase anchor protein inhibitor 1Add BLAST69

Proteomic databases

PaxDbiP0CW23.
PRIDEiP0CW23.

Expressioni

Tissue specificityi

Preferentially expressed in the neural tissues (PubMed:25653177).1 Publication

Gene expression databases

BgeeiENSG00000231824.
ExpressionAtlasiP0CW23. baseline and differential.

Organism-specific databases

HPAiHPA049365.

Interactioni

Subunit structurei

Binds cAMP-dependent protein kinase (PKA). Interacts specifically with RII-regulatory subunits of PKA (PRKAR2A and PRKAR2B) (PubMed:25653177).1 Publication

GO - Molecular functioni

  • protein kinase A binding Source: UniProtKB
  • protein kinase A regulatory subunit binding Source: GO_Central

Structurei

3D structure databases

ProteinModelPortaliP0CW23.
SMRiP0CW23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 33PKA-RII subunit binding domainCuratedAdd BLAST17

Domaini

The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Phylogenomic databases

eggNOGiENOG410JF47. Eukaryota.
ENOG411135H. LUCA.
GeneTreeiENSGT00560000078638.
InParanoidiP0CW23.
PhylomeDBiP0CW23.

Family and domain databases

InterProiIPR019511. AKAP7_RI-RII-bd_dom.
[Graphical view]
PfamiPF10470. AKAP7_RIRII_bdg. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CW23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFAPGEKPG NEPEEVKLQN ASKQIVQNAI LQAVQQVSQE SQRREERISD
60
NRDHIQLGVG ELTKKHEKK
Length:69
Mass (Da):7,848
Last modified:June 28, 2011 - v1
Checksum:iBB4ED950347AD8C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DA365827 mRNA. No translation available.
AP001496 Genomic DNA. No translation available.
AP005380 Genomic DNA. No translation available.
CCDSiCCDS54179.1.
RefSeqiNP_001138666.1. NM_001145194.1.
UniGeneiHs.437160.

Genome annotation databases

EnsembliENST00000434239; ENSP00000399075; ENSG00000231824.
GeneIDi642597.
KEGGihsa:642597.
UCSCiuc010wzc.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DA365827 mRNA. No translation available.
AP001496 Genomic DNA. No translation available.
AP005380 Genomic DNA. No translation available.
CCDSiCCDS54179.1.
RefSeqiNP_001138666.1. NM_001145194.1.
UniGeneiHs.437160.

3D structure databases

ProteinModelPortaliP0CW23.
SMRiP0CW23.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiC18orf42.
DMDMi338817804.

Proteomic databases

PaxDbiP0CW23.
PRIDEiP0CW23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000434239; ENSP00000399075; ENSG00000231824.
GeneIDi642597.
KEGGihsa:642597.
UCSCiuc010wzc.2. human.

Organism-specific databases

CTDi642597.
GeneCardsiC18orf42.
HGNCiHGNC:28285. AKAIN1.
HPAiHPA049365.
MIMi616427. gene.
neXtProtiNX_P0CW23.
OpenTargetsiENSG00000231824.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JF47. Eukaryota.
ENOG411135H. LUCA.
GeneTreeiENSGT00560000078638.
InParanoidiP0CW23.
PhylomeDBiP0CW23.

Miscellaneous databases

GenomeRNAii642597.
PROiP0CW23.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000231824.
ExpressionAtlasiP0CW23. baseline and differential.

Family and domain databases

InterProiIPR019511. AKAP7_RI-RII-bd_dom.
[Graphical view]
PfamiPF10470. AKAP7_RIRII_bdg. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAKAI1_HUMAN
AccessioniPrimary (citable) accession number: P0CW23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 2, 2016
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.