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Protein

A-kinase anchor protein C18orf42

Gene

C18orf42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A-kinase anchoring protein (AKAP)-mediated subcellular localization of PKA (PubMed:25653177).1 Publication

GO - Molecular functioni

  • protein kinase A binding Source: UniProtKB

GO - Biological processi

  • protein localization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein C18orf42
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:28285. C18orf42.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi25 – 251I → P: Reduces binding to RII subunits of PKA. 1 Publication

Polymorphism and mutation databases

BioMutaiC18orf42.
DMDMi338817804.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6969A-kinase anchor protein C18orf42PRO_0000410771Add
BLAST

Expressioni

Tissue specificityi

Preferentially expressed in the neural tissues (PubMed:25653177).1 Publication

Gene expression databases

BgeeiP0CW23.
ExpressionAtlasiP0CW23. baseline.
GenevisibleiP0CW23. HS.

Organism-specific databases

HPAiHPA049365.

Interactioni

Subunit structurei

Binds cAMP-dependent protein kinase (PKA). Interacts specifically with RII-regulatory subunits of PKA (PRKAR2A and PRKAR2B) (PubMed:25653177).1 Publication

Structurei

3D structure databases

ProteinModelPortaliP0CW23.
SMRiP0CW23. Positions 3-34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 3317PKA-RII subunit binding domainCuratedAdd
BLAST

Domaini

The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Phylogenomic databases

GeneTreeiENSGT00560000078638.
InParanoidiP0CW23.
PhylomeDBiP0CW23.

Family and domain databases

InterProiIPR019511. AKAP7_RI-RII-bd_dom.
[Graphical view]
PfamiPF10470. AKAP7_RIRII_bdg. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CW23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFAPGEKPG NEPEEVKLQN ASKQIVQNAI LQAVQQVSQE SQRREERISD
60
NRDHIQLGVG ELTKKHEKK
Length:69
Mass (Da):7,848
Last modified:June 28, 2011 - v1
Checksum:iBB4ED950347AD8C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DA365827 mRNA. No translation available.
AP001496 Genomic DNA. No translation available.
AP005380 Genomic DNA. No translation available.
CCDSiCCDS54179.1.
RefSeqiNP_001138666.1. NM_001145194.1.
UniGeneiHs.437160.

Genome annotation databases

EnsembliENST00000434239; ENSP00000399075; ENSG00000231824.
GeneIDi642597.
KEGGihsa:642597.
UCSCiuc010wzc.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DA365827 mRNA. No translation available.
AP001496 Genomic DNA. No translation available.
AP005380 Genomic DNA. No translation available.
CCDSiCCDS54179.1.
RefSeqiNP_001138666.1. NM_001145194.1.
UniGeneiHs.437160.

3D structure databases

ProteinModelPortaliP0CW23.
SMRiP0CW23. Positions 3-34.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiC18orf42.
DMDMi338817804.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000434239; ENSP00000399075; ENSG00000231824.
GeneIDi642597.
KEGGihsa:642597.
UCSCiuc010wzc.1. human.

Organism-specific databases

CTDi642597.
GeneCardsiGC18M005144.
HGNCiHGNC:28285. C18orf42.
HPAiHPA049365.
neXtProtiNX_P0CW23.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00560000078638.
InParanoidiP0CW23.
PhylomeDBiP0CW23.

Miscellaneous databases

GenomeRNAii642597.
NextBioi113967.
PROiP0CW23.

Gene expression databases

BgeeiP0CW23.
ExpressionAtlasiP0CW23. baseline.
GenevisibleiP0CW23. HS.

Family and domain databases

InterProiIPR019511. AKAP7_RI-RII-bd_dom.
[Graphical view]
PfamiPF10470. AKAP7_RIRII_bdg. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Subthalamic nucleus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Hypothetical gene C18orf42 encodes a novel protein kinase A-binding protein."
    Fukuda M., Aizawa Y.
    Genes Cells 20:267-280(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBUNIT, MUTAGENESIS OF ILE-25, FUNCTION.

Entry informationi

Entry nameiCR042_HUMAN
AccessioniPrimary (citable) accession number: P0CW23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: July 22, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.