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Protein

Testis-specific Y-encoded protein 10

Gene

TSPY10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Gonadal differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific Y-encoded protein 10
Gene namesi
Name:TSPY10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000233803.8
HGNCiHGNC:37473 TSPY10
neXtProtiNX_P0CW01

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi100289087
7258
728137
728395

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004080041 – 308Testis-specific Y-encoded protein 10Add BLAST308

Proteomic databases

MaxQBiP0CW01
PRIDEiP0CW01

Expressioni

Gene expression databases

BgeeiENSG00000233803
ExpressionAtlasiP0CW01 baseline
GenevisibleiP0CW01 HS

Organism-specific databases

HPAiHPA049384

Structurei

3D structure databases

ProteinModelPortaliP0CW01
SMRiP0CW01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1508 Eukaryota
ENOG410XQRX LUCA
GeneTreeiENSGT00530000062882
InParanoidiP0CW01
OrthoDBiEOG091G0FRU
PhylomeDBiP0CW01

Family and domain databases

InterProiView protein in InterPro
IPR037231 NAP-like_sf
IPR002164 NAP_family
PANTHERiPTHR11875 PTHR11875, 1 hit
PfamiView protein in Pfam
PF00956 NAP, 1 hit
SUPFAMiSSF143113 SSF143113, 1 hit

Sequencei

Sequence statusi: Complete.

P0CW01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPEGSLTYR VPERLRQGFC GVGRAAQALV CASAKEGTAF RMEAVQEGAA
60 70 80 90 100
GVESEQAALG EEAVLLLDDI MAEVEVVAEE EGLVERREEA QRAQQAVPGP
110 120 130 140 150
GPMTPESALE ELLAVQVELE PVNAQARKAF SRQREKMERR RKPHLDRRGA
160 170 180 190 200
VIQSVPGFWA NVIANHPQMS ALITDEDEDM LSYMVSLEVE EEKHPVHLCK
210 220 230 240 250
IMLFFRSNPY FQNKVITKEY LVNITEYRAS HSTPIEWYPD YEVEAYRRRH
260 270 280 290 300
HNSSLNFFNW FSDHNFAGSN KIAEILCKDL WRNPLQYYKR MKPPEEGTET

SGDSQLLS
Length:308
Mass (Da):35,101
Last modified:March 28, 2018 - v2
Checksum:i5FFC7E3EC4981A4B
GO

Polymorphismi

Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between 20 and 60 copies per Y chromosome are expected. 35 tandemly repeated gene copies on Yp11 originating from one individual have been reported (PubMed:12815422).1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006156 Genomic DNA No translation available.
RefSeqiNP_001071165.2, NM_001077697.2
NP_001269398.1, NM_001282469.2
UniGeneiHs.556121
Hs.646249
Hs.647493
Hs.730364

Genome annotation databases

EnsembliENST00000428845; ENSP00000406407; ENSG00000236424
GeneIDi100289087
728137
KEGGihsa:728395
UCSCiuc022cja.3 human

Similar proteinsi

Entry informationi

Entry nameiTSPYA_HUMAN
AccessioniPrimary (citable) accession number: P0CW01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: March 28, 2018
Last modified: April 25, 2018
This is version 47 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health