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Protein

Testis-specific Y-encoded protein 8

Gene

TSPY8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be involved in sperm differentiation and proliferation.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Gonadal differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific Y-encoded protein 8
Gene namesi
Name:TSPY8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

HGNCiHGNC:37471. TSPY8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiTSPY8.
DMDMi510120716.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Testis-specific Y-encoded protein 8PRO_0000408003Add
BLAST

Proteomic databases

PaxDbiP0CW00.

Expressioni

Gene expression databases

BgeeiP0CW00.
ExpressionAtlasiP0CW00. baseline and differential.
GenevisibleiP0CW00. HS.

Organism-specific databases

HPAiHPA049384.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000406407.

Structurei

3D structure databases

ProteinModelPortaliP0CW00.
SMRiP0CW00. Positions 106-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1508. Eukaryota.
ENOG410XQRX. LUCA.
GeneTreeiENSGT00530000062882.
InParanoidiP0CW00.
PhylomeDBiP0CW00.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 1 hit.
PfamiPF00956. NAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CW00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPEGSLTYW VPERLRQGFC GVGRAAQALV CASAKEGTAF RMEAVQEGAA
60 70 80 90 100
GVESEQAALG EEAVLLLDDI MAEVEVVAEE EGLVERREEA QRAQQAVPGP
110 120 130 140 150
GPMTPESALE ELLAVQVELE PVNAQARKAF SRQREKMERR RKPHLDRRGA
160 170 180 190 200
VIQSVPGFWA NVIANHPQMS ALITDEDEDM LSYMVSLEVE EEKHPVHLCK
210 220 230 240 250
IMLFFRSNPY FQNKVITKEY LVNITEYRAS HSTPIEWYLD YEVEAYRRRH
260 270 280 290 300
HNSSLNFFNW FSDHNFAGSN KIAEILCKDL WRNPLQYYKR MKPPEEGTET

SGDSQLLS
Length:308
Mass (Da):35,147
Last modified:May 29, 2013 - v2
Checksum:iC253A62F95CC4DC2
GO

Polymorphismi

Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between 20 and 60 copies per Y chromosome are expected. 35 tandemly repeated gene copies on Yp11 originating from one individual have been reported (PubMed:12815422).1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006158 Genomic DNA. No translation available.
CCDSiCCDS59533.1.
RefSeqiNP_001230650.1. NM_001243721.1.
UniGeneiHs.740264.

Genome annotation databases

EnsembliENST00000287721; ENSP00000287721; ENSG00000229549.
GeneIDi728403.
KEGGihsa:728403.
UCSCiuc004frr.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006158 Genomic DNA. No translation available.
CCDSiCCDS59533.1.
RefSeqiNP_001230650.1. NM_001243721.1.
UniGeneiHs.740264.

3D structure databases

ProteinModelPortaliP0CW00.
SMRiP0CW00. Positions 106-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000406407.

Polymorphism and mutation databases

BioMutaiTSPY8.
DMDMi510120716.

Proteomic databases

PaxDbiP0CW00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287721; ENSP00000287721; ENSG00000229549.
GeneIDi728403.
KEGGihsa:728403.
UCSCiuc004frr.3. human.

Organism-specific databases

CTDi728403.
GeneCardsiTSPY8.
HGNCiHGNC:37471. TSPY8.
HPAiHPA049384.
neXtProtiNX_P0CW00.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1508. Eukaryota.
ENOG410XQRX. LUCA.
GeneTreeiENSGT00530000062882.
InParanoidiP0CW00.
PhylomeDBiP0CW00.

Miscellaneous databases

GenomeRNAii728403.
NextBioi127050.
PROiP0CW00.

Gene expression databases

BgeeiP0CW00.
ExpressionAtlasiP0CW00. baseline and differential.
GenevisibleiP0CW00. HS.

Family and domain databases

InterProiIPR002164. NAP_family.
[Graphical view]
PANTHERiPTHR11875. PTHR11875. 1 hit.
PfamiPF00956. NAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTSPY8_HUMAN
AccessioniPrimary (citable) accession number: P0CW00
Secondary accession number(s): H7BXJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 29, 2013
Last modified: March 16, 2016
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.