ID   TSPY4_HUMAN             Reviewed;         314 AA.
AC   P0CV99;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   11-NOV-2015, entry version 38.
DE   RecName: Full=Testis-specific Y-encoded protein 4;
GN   Name=TSPY4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12815422; DOI=10.1038/nature01722;
RA   Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S.,
RA   Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T.,
RA   Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G.,
RA   Fulton L., Fulton R., Graves T.A., Hou S.-F., Latrielle P.,
RA   Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W.,
RA   Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K.,
RA   Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H.,
RA   Wilson R.K., Rozen S., Page D.C.;
RT   "The male-specific region of the human Y chromosome is a mosaic of
RT   discrete sequence classes.";
RL   Nature 423:825-837(2003).
CC   -!- FUNCTION: Unknown. May be involved in sperm differentiation and
CC       proliferation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- POLYMORPHISM: Maps to a tandemly repeated region on chromosome
CC       Yp11; additionally at least one copy is reported originating from
CC       Yq. The gene is thought to be present with an inter-individual
CC       variation in copy number and between 20 and 60 copies per Y
CC       chromosome are expected. 35 tandemly repeated gene copies on Yp11
CC       originating from one individual have been reported
CC       (PubMed:12815422). {ECO:0000269|PubMed:12815422}.
CC   -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP)
CC       family. {ECO:0000305}.
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DR   EMBL; AC006158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS48202.1; -.
DR   RefSeq; NP_001157943.1; NM_001164471.1.
DR   UniGene; Hs.556121; -.
DR   UniGene; Hs.646249; -.
DR   UniGene; Hs.647493; -.
DR   UniGene; Hs.730364; -.
DR   ProteinModelPortal; P0CV99; -.
DR   SMR; P0CV99; 112-294.
DR   STRING; 9606.ENSP00000399668; -.
DR   BioMuta; TSPY4; -.
DR   DMDM; 332321775; -.
DR   PaxDb; P0CV99; -.
DR   Ensembl; ENST00000426950; ENSP00000399668; ENSG00000233803.
DR   GeneID; 728395; -.
DR   KEGG; hsa:728395; -.
DR   UCSC; uc004fse.3; human.
DR   CTD; 728395; -.
DR   GeneCards; TSPY4; -.
DR   HGNC; HGNC:37287; TSPY4.
DR   HPA; HPA049384; -.
DR   neXtProt; NX_P0CV99; -.
DR   eggNOG; KOG1508; Eukaryota.
DR   eggNOG; ENOG410XQRX; LUCA.
DR   InParanoid; P0CV99; -.
DR   OrthoDB; EOG7FBRJB; -.
DR   PhylomeDB; P0CV99; -.
DR   TreeFam; TF313386; -.
DR   GenomeRNAi; 728395; -.
DR   NextBio; 127050; -.
DR   PRO; PR:P0CV99; -.
DR   Proteomes; UP000005640; Chromosome Y.
DR   Bgee; P0CV99; -.
DR   Genevisible; P0CV99; HS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR002164; NAP_family.
DR   PANTHER; PTHR11875; PTHR11875; 1.
DR   Pfam; PF00956; NAP; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Developmental protein; Differentiation;
KW   Gonadal differentiation; Nucleus; Reference proteome; Spermatogenesis.
FT   CHAIN         1    314       Testis-specific Y-encoded protein 4.
FT                                /FTId=PRO_0000408002.
SQ   SEQUENCE   314 AA;  35727 MW;  3B226B3C96F703F4 CRC64;
     MRPEGSLTYR VPERLRQGFC GVGRAAQALV CASAKEGTAF RMEAVQEGAA GVESEQAALG
     EEAVLLLDDI MAEVEVVAEV EVVAEEEGLV ERREEAQRAQ QAVPGPGPMT PESALEELLA
     VQVELEPVNA QARKAFSRQR EKMERRRKPH LDRRGAVIQS VPGFWANVIA NHPQMSALIT
     DEDEDMLSYM VSLEVEEEKH PVHLCKIMLF FRSNPYFQNK VITKEYLVNI TEYRASHSTP
     IEWYPDYEVE AYRRRHHNSS LNFFNWFSDH NFAGSNKIAE ILCKDLWRNP LQYYKRMKPP
     EEGTETSGDS QLLS
//