Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Testis-specific Y-encoded protein 4

Gene

TSPY4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Gonadal differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific Y-encoded protein 4
Gene namesi
Name:TSPY4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

EuPathDBiHostDB:ENSG00000233803.8
HGNCiHGNC:37287 TSPY4
neXtProtiNX_P0CV99

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi100289087
7258
728137
728395

Polymorphism and mutation databases

BioMutaiTSPY4
DMDMi332321775

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004080021 – 314Testis-specific Y-encoded protein 4Add BLAST314

Proteomic databases

PaxDbiP0CV99
PRIDEiP0CV99

Expressioni

Gene expression databases

BgeeiENSG00000233803
ExpressionAtlasiP0CV99 baseline
GenevisibleiP0CV99 HS

Organism-specific databases

HPAiHPA049384

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000399668

Structurei

3D structure databases

ProteinModelPortaliP0CV99
SMRiP0CV99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1508 Eukaryota
ENOG410XQRX LUCA
GeneTreeiENSGT00530000062882
InParanoidiP0CV99
OMAiSTPVQWH
OrthoDBiEOG091G0FRU
PhylomeDBiP0CV99
TreeFamiTF313386

Family and domain databases

InterProiView protein in InterPro
IPR037231 NAP-like_sf
IPR002164 NAP_family
PANTHERiPTHR11875 PTHR11875, 1 hit
PfamiView protein in Pfam
PF00956 NAP, 1 hit
SUPFAMiSSF143113 SSF143113, 1 hit

Sequencei

Sequence statusi: Complete.

P0CV99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPEGSLTYR VPERLRQGFC GVGRAAQALV CASAKEGTAF RMEAVQEGAA
60 70 80 90 100
GVESEQAALG EEAVLLLDDI MAEVEVVAEV EVVAEEEGLV ERREEAQRAQ
110 120 130 140 150
QAVPGPGPMT PESALEELLA VQVELEPVNA QARKAFSRQR EKMERRRKPH
160 170 180 190 200
LDRRGAVIQS VPGFWANVIA NHPQMSALIT DEDEDMLSYM VSLEVEEEKH
210 220 230 240 250
PVHLCKIMLF FRSNPYFQNK VITKEYLVNI TEYRASHSTP IEWYPDYEVE
260 270 280 290 300
AYRRRHHNSS LNFFNWFSDH NFAGSNKIAE ILCKDLWRNP LQYYKRMKPP
310
EEGTETSGDS QLLS
Length:314
Mass (Da):35,727
Last modified:May 3, 2011 - v1
Checksum:i3B226B3C96F703F4
GO

Polymorphismi

Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between 20 and 60 copies per Y chromosome are expected. 35 tandemly repeated gene copies on Yp11 originating from one individual have been reported (PubMed:12815422).1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006158 Genomic DNA No translation available.
CCDSiCCDS48202.1
RefSeqiNP_001157943.1, NM_001164471.1
UniGeneiHs.556121
Hs.646249
Hs.647493
Hs.730364

Genome annotation databases

EnsembliENST00000426950; ENSP00000399668; ENSG00000233803
GeneIDi728395
KEGGihsa:728395

Similar proteinsi

Entry informationi

Entry nameiTSPY4_HUMAN
AccessioniPrimary (citable) accession number: P0CV99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 3, 2011
Last modified: April 25, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health