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Protein

Elongation factor 1-alpha-A

Gene

tef101

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 21GTPBy similarity8
Nucleotide bindingi91 – 95GTPBy similarity5
Nucleotide bindingi153 – 156GTPBy similarity4

GO - Molecular functioni

  • calmodulin binding Source: PomBase
  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • translation elongation factor activity Source: PomBase

GO - Biological processi

  • cytoplasmic translational elongation Source: PomBase

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-156842 Eukaryotic Translation Elongation
R-SPO-3371511 HSF1 activation
R-SPO-6798695 Neutrophil degranulation
R-SPO-8876725 Protein methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-alpha-A
Short name:
EF-1-alpha-A
Gene namesi
Name:tef101
Synonyms:ef1a-a, tef1a, tef1e
ORF Names:SPCC794.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:SPCC794.09c
PomBaseiSPCC794.09c tef101

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000909682 – 460Elongation factor 1-alpha-AAdd BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N,N,N-trimethylglycineBy similarity1
Modified residuei3N6,N6-dimethyllysine; alternateBy similarity1
Modified residuei3N6-methyllysine; alternateBy similarity1
Modified residuei30N6-methyllysineBy similarity1
Modified residuei79N6,N6,N6-trimethyllysineBy similarity1
Modified residuei316N6,N6-dimethyllysine; alternateBy similarity1
Modified residuei316N6-methyllysine; alternateBy similarity1
Modified residuei390N6-methyllysineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP0CT53
PRIDEiP0CT53

PTM databases

iPTMnetiP0CT53

Interactioni

GO - Molecular functioni

  • calmodulin binding Source: PomBase

Protein-protein interaction databases

IntActiP0CT53, 6 interactors
MINTiP0CT53
STRINGi4896.SPCC794.09c.1

Structurei

3D structure databases

ProteinModelPortaliP0CT53
SMRiP0CT53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 240tr-type GAdd BLAST236

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 21G1By similarity8
Regioni70 – 74G2By similarity5
Regioni91 – 94G3By similarity4
Regioni153 – 156G4By similarity4
Regioni192 – 194G5By similarity3

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000229291
InParanoidiP50522
KOiK03231
OMAiPAKETKM
PhylomeDBiP0CT53

Family and domain databases

HAMAPiMF_00118_A EF_Tu_A, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004539 Transl_elong_EF1A_euk/arc
IPR004160 Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PF03143 GTP_EFTU_D3, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00483 EF-1_alpha, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CT53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKEKGHINV VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEATELG
60 70 80 90 100
KGSFKYAWVL DKLKAERERG ITIDIALWKF ETPKYNVTVI DAPGHRDFIK
110 120 130 140 150
NMITGTSQAD CAVLIIGGGT GEFEAGISKD GQTREHALLA YTLGVKQLIV
160 170 180 190 200
AVNKMDTTGW SQARFEEIVK ETSNFIKKVG FNPKTVPFVP VSGFQGDNMI
210 220 230 240 250
EPTTNMPWYQ GWQKETKAGV VKGKTLLEAI DSIEPPARPT DKPLRLPLQD
260 270 280 290 300
VYKIGGIGTV PVGRVETGVI KPGMIVTFAP AGVTTEVKSV EMHHESLDAG
310 320 330 340 350
LPGDNVGFNV KNVSVKDIRR GNVCGDSKND PPMGCASFTA QVIILNHPGQ
360 370 380 390 400
ISAGYSPVLD CHTAHIACKF AELIEKIDRR SGKKIEESPK FVKSGDACIA
410 420 430 440 450
KMVPSKPMCV EAFTDYAPLG RFAVRDMRQT VAVGVIKAVE KVAPGAAKVT
460
KAAVKAGAKK
Length:460
Mass (Da):49,660
Last modified:June 24, 2015 - v1
Checksum:i82EA58185D514294
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47T → F in AAB63859 (Ref. 5) By similarity1
Sequence conflicti47T → F in AAB63865 (Ref. 5) By similarity1
Sequence conflicti57A → S in AAB63859 (Ref. 5) By similarity1
Sequence conflicti57A → S in AAB63865 (Ref. 5) By similarity1
Sequence conflicti113V → I in BAA19867 (PubMed:9501991).By similarity1
Sequence conflicti139L → R in BAA11569 (PubMed:9099890).By similarity1
Sequence conflicti139L → V in BAA19867 (PubMed:9501991).By similarity1
Sequence conflicti140A → G in AAA85129 (PubMed:10593605).By similarity1
Sequence conflicti422F → FG in AAA85129 (PubMed:10593605).By similarity1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82571 mRNA Translation: BAA11569.1
U42189 mRNA Translation: AAA85129.1
D89112 mRNA Translation: BAA19867.1
CU329672 Genomic DNA Translation: CAA19136.1
U97367 mRNA Translation: AAB63859.1
U97373 mRNA Translation: AAB63865.1
PIRiB41453
T41617
T42089
T43267
T43704
RefSeqiNP_587757.1, NM_001022750.2

Genome annotation databases

EnsemblFungiiSPCC794.09c.1; SPCC794.09c.1:pep; SPCC794.09c
GeneIDi2539035
KEGGispo:SPCC794.09c

Entry informationi

Entry nameiEF1A1_SCHPO
AccessioniPrimary (citable) accession number: P0CT53
Secondary accession number(s): O14372
, O14441, O59818, P50522, P78764, Q10117, Q10119, Q10158, Q7M4U9, Q7Z8V5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: June 24, 2015
Last modified: May 23, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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